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公开(公告)号：EP1086085A1
公开(公告)日：2001-03-28
申请号：EP99927377.4
申请日：1999-06-11
发明人： SALITURO, Francesco , BEMIS, Guy , COCHRAN, John
IPC分类号： C07D217/24 , C07D239/80 , C07D239/96 , A61K31/505 , A61K31/47
CPC分类号： C07D239/96 , C07D217/24 , C07D239/60 , C07D239/80
摘要： The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
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2.发明公开
公开(公告)号：EP1809290A2
公开(公告)日：2007-07-25
申请号：EP05851346.6
申请日：2005-11-03
发明人： MARTINBOROUGH, Esther , ZIMMERMANN, Nicole , PERNI, Robert , ARNOST, Michael , BANDARAGE, Upul , MALTAIS, Francois , BEMIS, Guy
IPC分类号： A61K31/506 , C07D401/12 , C07D403/06 , C07D405/12 , C07D403/12 , C07D409/12 , C07D403/04 , C07D239/30 , C07D405/14 , C07D413/06 , C07D413/04 , A61P25/28
CPC分类号： C07D409/14 , A61K31/506 , C07D239/28 , C07D239/30 , C07D239/42 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/06
摘要： In general, the invention relates to compounds useful as ion channel modulators. It has now been found that compounds of this invention, and pharmaceutically acceptable compositions thereof, are useful as inhibitors of voltage-gated sodium channels and/or calcium channels.
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3.发明公开INHIBITORS OF c-JUN N-TERMINAL KINASES (JNK) AND OTHER PROTEIN KINASES 有权c-Jun N-末端激酶（JNK）AND OTHER蛋白抑制剂KINASES-
公开(公告)号：EP1218369A1
公开(公告)日：2002-07-03
申请号：EP00957485.6
申请日：2000-08-11
发明人： GREEN, Jeremy , BEMIS, Guy , GRILLOT, Anne-Laure , LEDEBOER, Mark , SALITURO, Francis , HARRINGTON, Edmund , GAO, Huai , BAKER, Christopher , CAO, Jingrong , HALE, Michael
IPC分类号： C07D401/04 , C07D405/04 , C07D403/04 , C07D413/04 , A61K31/341 , A61K31/4155 , A61K31/4192 , A61K31/42
CPC分类号： C07D413/04 , A61K31/341 , A61K31/4155 , A61K31/4192 , A61K31/42 , C07D413/14
摘要： The present invention provides compounds of formula (I) where R1 is H, CONH¿2?, T(n)-R, or T(n)-Ar?2¿, n may be zero or one, and G, XYZ, and Q are as described below. These compounds are inhibitors of protein kinase, particularly inhibitors of JNK, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
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公开(公告)号：EP1200422A2
公开(公告)日：2002-05-02
申请号：EP01908911.9
申请日：2001-02-05
发明人： GREEN, Jeremy , CAO, Jingrong , HALE, Michael , BAKER, Christopher , MALTAIS, Francois , JANETKA, James , MULLICAN, Michael , BEMIS, Guy , XIE, Xiaoling , STRAUB, Judith , TANG, Qing , MASHALL, Robert
IPC分类号： C07D403/04 , C07D471/04 , C07D403/14 , C07D401/04 , A61K31/33
CPC分类号： C07D401/14 , C07D231/38 , C07D403/04 , C07D403/14 , C07D405/14 , C07D417/14 , C07D471/04
摘要： Described herein are compounds that are useful as protein kinase inhibitors having the formula: (I) where R1-4, Q, and T are described inthe specification. The compounds are useful for treating disease states in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, and cardiovascular disease.
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5.发明公开
公开(公告)号：EP2464641A1
公开(公告)日：2012-06-20
申请号：EP10745687.3
申请日：2010-08-13
发明人： WANG, Tiansheng , HANZELKA, Brian , MUH, Ute , BEMIS, Guy , ZUCCOLA, Harmon, J.
IPC分类号： C07D403/12 , C07D403/14 , C07D409/14 , C07D487/04 , A61K31/506 , A61P31/06
CPC分类号： C07D403/12 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/551 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D417/14 , C07D487/04 , C07D487/14 , C07D487/16
摘要： The present invention relates to compounds II useful as inhibitors of treating tuberculosis. The invention also provides processes for preparing compounds of the invention.
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公开(公告)号：EP1077943B1
公开(公告)日：2008-12-17
申请号：EP99920427.4
申请日：1999-05-11
IPC分类号： C07D213/56 , A61K31/44 , C07D213/75 , C07D213/74 , C07D401/06 , C07D213/73
CPC分类号： C07D213/74 , C04B35/01 , C07D213/56 , C07D213/75 , C07D217/22
摘要： The present invention relates to inhibitors of p38, a mammalian protein kinase involved in cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
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7.发明公开
公开(公告)号：EP1417205A1
公开(公告)日：2004-05-12
申请号：EP02744355.5
申请日：2002-06-14
发明人： BEMIS, Guy , GAO, Huai , HARRINGTON, Edmund , LEDEBOER, Mark , SALITURO, Francesco , WANG, Jian
IPC分类号： C07D413/04 , A61K31/506 , A61P35/02 , A61P37/00
CPC分类号： C07D413/04
摘要： The present invention provides compounds of formula I or a pharmaceutically acceptable derivative thereof, wherein A-B is N-O or O-N and G, R?1, R2, R3, and R4¿ are as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibitors of Src and Lck kinase. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
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公开(公告)号：EP1309560A1
公开(公告)日：2003-05-14
申请号：EP01962021.0
申请日：2001-08-10
发明人： COCHRAN, John , GALULLO, Vincent , BEMIS, Guy
IPC分类号： C07D213/75 , C07D401/12 , A61K31/4418 , A61P7/00 , A61P9/00 , A61P17/00 , A61P25/00 , A61P31/00 , C07F9/58
CPC分类号： C07D213/75 , C07D401/12 , C07F9/582 , C07F9/588
摘要： The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to inhibitors of ZAP70. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders. These compounds have the general formula: (Ia), (Ib), (Ic) and (Id).
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公开(公告)号：EP3784666A1
公开(公告)日：2021-03-03
申请号：EP19726792.5
申请日：2019-04-23
发明人： YU, Henry , CLARK, Michael , BEMIS, Guy , BOYD, Michael , CHANDUPATLA, Kishan , COLLIER, Philip , DENG, Hongbo , DONG, Huijun , DORSCH, Warren , HOOVER, Russell, R. , JOHNSON, Mac, Arthur, JR. , KUKAMI, Shashank , PENNEY, Marina , RONKIN, Steven , TAKEMOTO, Darin , TANG, Qing , WAAL, Nathan, D. , WANG, Tiansheng , LAUFFER, David J. , LI, Pan
IPC分类号： C07D413/14 , C07D403/04 , C07D409/14 , C07D413/04 , A61K31/553 , A61P35/00
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公开(公告)号：EP1309560B1
公开(公告)日：2012-10-03
申请号：EP01962021.0
申请日：2001-08-10
发明人： COCHRAN, John , GALULLO, Vincent , BEMIS, Guy
IPC分类号： C07D213/75 , C07D401/12 , A61K31/4418 , A61P7/00 , A61P9/00 , A61P17/00 , A61P25/00 , A61P31/00 , C07F9/58
CPC分类号： C07D213/75 , C07D401/12 , C07F9/582 , C07F9/588
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