公开(公告)号：EP2291358B1

公开(公告)日：2018-03-28

申请号：EP09747426.6

申请日：2009-05-13

申请人： Merck Sharp & Dohme Corp.

发明人： GREENLEE, William, J. ,  STAMFORD, Andrew ,  MILLER, Michael, W. ,  DEMONG, Duane, Eugene

IPC分类号： C07D231/22 ,  C07D231/38 ,  A61K31/415

CPC分类号： C07D231/22 ,  C07D231/38

摘要： The present invention relates to compounds of general formula (I), wherein ring A, ring B, R1, R2, R3, Z, and L1 are selected independently of each other and are as defined herein, to compositions comprising the compounds, and methods of using the compounds as glucagon receptor antagonists and for the treatment or prevention of type 2 diabetes and conditions related thereto.

公开(公告)号：EP2350020B1

公开(公告)日：2014-08-13

申请号：EP09741076.5

申请日：2009-09-30

申请人： Merck Sharp & Dohme Corp.

发明人： STAMFORD, Andrew ,  MILLER, Michael, W. ,  DEMONG, Duane, Eugene ,  GREENLEE, William, J. ,  KOZLOWSKI, Joseph, A. ,  LAVEY, Brian, J. ,  WONG, Michael, K.C. ,  YU, Wensheng ,  DAI, Xing ,  YANG, De-Yi ,  ZHOU, Guowei

IPC分类号： C07D235/02 ,  C07D401/04 ,  C07D401/06 ,  C07D401/10 ,  C07D401/14 ,  C07D403/12 ,  C07D491/10 ,  A61K31/4184 ,  A61K31/4188 ,  A61K31/4439 ,  A61K31/4453 ,  A61K31/47

CPC分类号： C07D235/02 ,  A61K31/4184 ,  A61K45/06 ,  C07D401/04 ,  C07D401/06 ,  C07D401/10 ,  C07D401/14 ,  C07D403/12 ,  C07D491/10 ,  A61K2300/00