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1.发明授权PIPERIDINONE CARBOXAMIDE AZAINDANE CGRP RECEPTOR ANTAGONISTS 有权PIPERIDINONCARBOXAMIDAZAINDAN衍生物作为CGRP受体拮抗剂
公开(公告)号：EP2638042B1
公开(公告)日：2014-09-24
申请号：EP11787987.4
申请日：2011-11-10
发明人： BELL, Ian, M. , FRALEY, Mark, E. , GALLICCHIO, Steven, N. , GINNETTI, Anthony , MITCHELL, Helen, J. , PAONE, Daniel, V. , STAAS, Donnette, D. , WANG, Cheng , ZARTMAN, C. Blair , STEVENSON, Heather, E.
IPC分类号： C07D471/10 , A61K31/519 , A61K31/437 , A61P9/08
CPC分类号： A61K31/4545 , A61K31/435 , A61K31/438 , C07D471/10 , C07D471/20
摘要： The present invention is directed to piperidinone carboxamide azaindane derivatives of formula I which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
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公开(公告)号：EP2249833A1
公开(公告)日：2010-11-17
申请号：EP09708648.2
申请日：2009-02-04
IPC分类号： A61K31/44 , A61K31/55 , A61K31/517
CPC分类号： C07D471/04 , C07F9/6561
摘要： Disclosed are prodrug compounds of formula (I) (wherein variables R1 and R2 are as described herein) which are analogues of an antagonist of CGRP receptors and which are useful in the treatment or prevention of diseases in which CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
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公开(公告)号：EP2024358B1
公开(公告)日：2014-11-05
申请号：EP07776804.2
申请日：2007-05-04
发明人： WOOD, Michael, R. , BELL, Ian, M. , GALLICCHIO, Steven, N. , SELNICK, Harold, G. , STUMP, Craig, A. , ZARTMAN, C. Blair
IPC分类号： C07D401/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D519/00 , A61K31/403 , A61K31/407 , C07D471/20 , A61K31/4184 , A61K31/4188 , A61K31/4439 , A61K31/438 , A61K31/4965 , A61K31/499
CPC分类号： C07D401/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D471/20 , C07D519/00
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公开(公告)号：EP2638042A1
公开(公告)日：2013-09-18
申请号：EP11787987.4
申请日：2011-11-10
发明人： BELL, Ian, M. , FRALEY, Mark, E. , GALLICCHIO, Steven, N. , GINNETTI, Anthony , MITCHELL, Helen, J. , PAONE, Daniel, V. , STAAS, Donnette, D. , WANG, Cheng , ZARTMAN, C. Blair , STEVENSON, Heather, E.
IPC分类号： C07D471/10 , A61K31/519 , A61K31/437 , A61P9/08
CPC分类号： A61K31/4545 , A61K31/435 , A61K31/438 , C07D471/10 , C07D471/20
摘要： The present invention is directed to piperidinone carboxamide azaindane derivatives of formula I which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及作为CGRP受体的拮抗剂的式I的哌啶酮羧酰胺氮杂茚衍生物，其可用于治疗或预防涉及CGRP的疾病如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：EP1793827B1
公开(公告)日：2010-04-07
申请号：EP05796847.1
申请日：2005-09-06
发明人： BELL, Ian, M. , GALLICCHIO, Steven, N. , STUMP, Craig, A. , THEBERGE, Cory, R. , VACCA, Joseph, P. , ZARTMAN, C. Blair , ZHANG, Xufang
IPC分类号： A61K31/505 , C07D471/02
CPC分类号： C07D519/00 , C07D209/96 , C07D471/06 , C07D471/16 , C07D487/06
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公开(公告)号：EP1951051B1
公开(公告)日：2012-10-03
申请号：EP06827801.9
申请日：2006-11-14
发明人： BELL, Ian, M. , STUMP, Craig, A. , THEBERGE, Cory, R. , GALLICCHIO, Steven, N. , ZARTMAN, C. Blair
IPC分类号： C07D519/00 , A61K31/4747 , A61K31/4985 , A61K31/499 , A61K31/551 , A61K31/4745 , A61K31/55 , A61P25/06
CPC分类号： C07D519/00
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7.发明授权TRICYCLIC ANILIDE SPIROHYDANTOIN CGRP RECEPTOR ANTAGONISTS 有权TRICYCLISCHE ANILID-SPIROHYDANTOIN-CGRP-REZEPTORANTAGONISTEN
公开(公告)号：EP1794146B1
公开(公告)日：2011-08-03
申请号：EP05796599.8
申请日：2005-09-09
发明人： BELL, Ian, M. , GALLICCHIO, Steven, N. , ZARTMAN, C. Blair , THEBERGE, Cory, R. , ZHANG, Xufang
IPC分类号： C07D401/12 , C07D403/12 , A61K31/519 , A61K31/4166 , A61P25/06
CPC分类号： C07D487/06 , C07D471/06
摘要： The present invention is directed to compounds of Formula I: I (where A1, A2, B1, B2, B3, B4, D1, D2, T, U, V, W, X, Y, Z, R4, R5a?, R5b, R5c, R6, m and n are defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
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8.发明授权
公开(公告)号：EP2637656B1
公开(公告)日：2016-12-14
申请号：EP11840630.5
申请日：2011-11-10
发明人： BELL, Ian, M. , FRALEY, Mark, E. , GALLICCHIO, Steven, N. , GINNETTI, Anthony , MITCHELL, Helen, J. , PAONE, Daniel, V. , STAAS, Donnette, D. , WANG, Cheng , ZARTMAN, Blair, C. , STEVENSON, Heather, E.
IPC分类号： C07D471/04 , C07D487/04 , A61K31/40 , A61K31/445 , A61K31/506
CPC分类号： C07D471/04 , A61K31/506 , C07D487/04
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公开(公告)号：EP2249833B1
公开(公告)日：2012-10-17
申请号：EP09708648.2
申请日：2009-02-04
IPC分类号： C07D471/04 , C07F9/6561 , A61K31/55 , A61P25/06
CPC分类号： C07D471/04 , C07F9/6561
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公开(公告)号：EP1613368B1
公开(公告)日：2011-11-30
申请号：EP04719234.9
申请日：2004-03-10
IPC分类号： C07D235/02 , C07D233/02 , A61K31/415 , A61P25/06
CPC分类号： C07D233/78 , C07D235/02 , C07D401/12 , C07D403/12 , C07D413/12 , C07D471/10 , C07D513/04
摘要： The present invention is directed to compounds that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
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