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    ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS AND USES THEREOF
    3.
    发明公开
    ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS AND USES THEREOF 有权
    ALPHA-7-MODULATOREN DES NIKOTINISCHEN ACETYLCHOLINREZEPTORS UND VERWENDUNGEN DAVON

    公开(公告)号：EP3154537A1

    公开(公告)日：2017-04-19

    申请号：EP15806506.0

    申请日：2015-06-11

    申请人： Merck Sharp & Dohme Corp.

    发明人： LEAVITT, Kenneth ,  CROWLEY, Brendan ,  BELL, Ian, M. ,  HARVEY, Andrew ,  AVERY, Thomas ,  PAUL, Dharam ,  RIPPER, Justin ,  HUFF, Belinda ,  SINGH, Rajinder ,  SCHAEFFER, Laurent ,  JOSEPH, Christophe ,  MORICE, Christophe ,  GIETHLEN, Bruno ,  BAZZINI, Patrick ,  FROMEYER, Aurelie

    IPC分类号： A61K31/18 ,  C07C311/08 ,  C07C311/37

    摘要： Disclosed are compounds of Formula (IVA), or a salt thereof, and pharmaceutical formulations (pharmaceutical compositions) comprising those compounds, or a salt thereof: Formula (IVA), wherein "RIa", "RIb", "RIc", "RId", "RIe", are defined herein above, which compounds are believed suitable for use in positive modulation of the alpha 7 nicotinic acetylcholine receptor (α7 nAChR) receptors, for example, those found in the cerebral cortex and the hippocampus. Such compounds and pharmaceutical formulations are believed to be useful in treatment or management of neurodegenerative diseases, for example, Alzheimer's disease (AD), schizophrenia, and Parkinson's disease (PD), or movement disorders arising from use of certain medications used in the treatment or management of Parkinson's disease.

    摘要翻译： 公开了式（IVA）化合物或其盐，以及包含那些化合物或其盐的药物制剂（药物组合物）：式（IVA），其中“RIa”，“RIb”，“RIc”，“RId “，”RIe“定义如上，这些化合物被认为适合用于阳性调节α7烟碱乙酰胆碱受体（α7nAChR）受体，例如在大脑皮层和海马中发现的受体。 据信这些化合物和药物制剂可用于治疗或治疗神经变性疾病，例如阿尔茨海默病（AD），精神分裂症和帕金森病（PD），或由于使用某些药物而引起的运动障碍，用于治疗或 管理帕金森病。