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公开(公告)号：EP4444722A1
公开(公告)日：2024-10-16
申请号：EP22850760.4
申请日：2022-12-05
申请人： Merck Sharp & Dohme LLC , THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH , MSD R&D (China) Co., Ltd.
发明人： MCCAULEY, John, A. , DE LERA RUIZ, Manuel , GUO, Zhuyan , NANTERMET, Philippe , KELLY III, Michael, J. , GUTIERREZ BONET, Alvaro , ZHAO, Lianyun , LEI, Zhiyu , HU, Bin , ZHAN, Dongmei , HODDER, Anthony
IPC分类号： C07D491/16 , C07D491/18 , C07D491/22 , A61K31/519 , A61P33/06
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公开(公告)号：EP4384178A1
公开(公告)日：2024-06-19
申请号：EP22856636.0
申请日：2022-08-11
发明人： SHURTLEFF, Valerie, W. , CROWLEY, Brendan, M. , FELLS, James, I. , KIM, Ronald, M. , LIAO, Jennie , MCCAULEY, John, A. , SCHREIER, John, D. , SU, Hua-poo , ZHANG, Yonglian , ZHAO, Lianyun
IPC分类号： A61K31/53 , A61K31/5365 , A61K31/395
CPC分类号： A61P31/16 , C07D471/18
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3.发明公开
公开(公告)号：EP3873467A2
公开(公告)日：2021-09-08
申请号：EP19879545.2
申请日：2019-10-24
发明人： ACTON, John, J., III , EGBERTSON, Melissa , GAO, Xiaolei , HARRISON, Scott, T. , HENDERSON, Timothy, J. , LO, Michael Man-Chu , MAZZOLA, Robert, D., Jr. , MENG, Zhaoyang , MULHEARN, James , RADA, Vanessa, L. , SCHUBERT, Jeffrey, W. , SELYUTIN, Oleg, B. , TELLERS, David, M. , TONG, Ling , ZHANG, Fengqi , BAO, Jianming , LI, Chunsing
IPC分类号： A61K31/437 , A61K31/4439 , A61P25/16
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4.发明公开
公开(公告)号：EP3644992A1
公开(公告)日：2020-05-06
申请号：EP18825469.2
申请日：2018-06-22
发明人： ACTON, John, J., III , BAO, Jianming , DENG, Qiaolin , EGBERTSON, Melissa , FERGUSON, Ronald, III , GAO, Xiaolei , HARRISON, Scott Timothy , KNOWLES, Sandra L. , LI, Chunsing , LO, Michael Man-Chu , MAZZOLA, Robert D., Jr. , MENG, Zhaoyang , NA, Meng , RUDD, Michael T. , SELYUTIN, Oleg B. , TELLERS, David M. , TONG, Ling , ZHANG, Fengqi
IPC分类号： A61K31/4155 , C07D231/10
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5.发明公开
公开(公告)号：EP3558310A1
公开(公告)日：2019-10-30
申请号：EP17884553.3
申请日：2017-12-18
发明人： BAO, Jianming , FERGUSON, Ronald , GAO, Xiaolei , HARRISON, Scott , KNOWLES, Sandra, L. , LO, Michael Man-Chu , MAZZOLA, Robert, D., Jr. , SCHUBERT, Jeffrey, W.
IPC分类号： A61K31/445 , A61K31/495 , A61K31/496 , C07D401/00 , C07D401/02 , C07D401/04
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6.发明公开
公开(公告)号：EP3393472A1
公开(公告)日：2018-10-31
申请号：EP16879916.1
申请日：2016-12-19
发明人： ACTON, John, J., III , BAO, Jianming , EGBERTSON, Melissa , GAO, Xiaolei , HARRISON, Scott T. , KNOWLES, Sandra L. , LI, Chunsing , LO, Michael Man-Chu , MAZZOLA, Robert D., Jr. , MENG, Zhaoyang , RUDD, Michael, T. , SELYUTIN, Oleg , TELLERS, David, M. , TONG, Ling , WAI, Jenny Miu-Chun
IPC分类号： A61K31/4155 , C07D231/10
摘要： The present invention is directed to pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.
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公开(公告)号：EP3197451A4
公开(公告)日：2018-02-28
申请号：EP15843799
申请日：2015-09-23
发明人： CAI JIAQIANG , CRESPO ALEJANDRO , DU XIAOXING , DUBOIS BYRON GABRIEL , LIU PING , LIU RONGQIANG , QUAN WEIGUO , SINZ CHRISTOPHER , WANG LIPING
IPC分类号： C07D491/04 , A61K31/4355 , A61P7/06 , A61P9/10
CPC分类号： C07D491/048 , A61P7/06 , A61P9/10
摘要： The present invention concerns compounds of formula I or pharmaceutically acceptable salts thereof, which inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.
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公开(公告)号：EP3197455A1
公开(公告)日：2017-08-02
申请号：EP15845304.3
申请日：2015-09-23
发明人： CAI, Jiaqiang , COLANDREA, Vincent , CRESPO, Alejandro , DEBENHAM, John , DU, Xiaoxing , GUIADEEN, Deodialsingh , LIU, Ping , LIU, Rongqiang , MADSEN-DUGGAN, Cristina, B. , MCCOY, Joshua, G. , QUAN, Weiguo , SINZ, Christopher , WANG, Liping
IPC分类号： A61K31/4704
CPC分类号： C07D491/052 , C07D215/56 , C07D221/22 , C07D417/06 , C07D471/04
摘要： The present invention concerns a compound of formula I or a pharmaceutically acceptable salt thereof, which inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.
摘要翻译： 本发明涉及抑制HIF脯氨酰羟化酶的式I化合物或其药学上可接受的盐，它们用于增强促红细胞生成素的内源性产生，以及用于治疗与促红细胞生成素内源性产生减少相关的疾病如贫血等疾病， 以及包含这种化合物和药物载体的药物组合物。
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公开(公告)号：EP4100401A1
公开(公告)日：2022-12-14
申请号：EP21751452.0
申请日：2021-02-02
申请人： Merck Sharp & Dohme LLC , THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH , MSD R&D (China) Co., Ltd.
发明人： DE LERA RUIZ, Manuel , FAVUZZA, Paola , GUO, Zhuyan , HU, Bin , KELLY III, Michael J. , LEI, Zhiyu , MCCAULEY, John A. , OLSEN, David B. , SLEEBS, Brad , TRIGLIA, Tony , ZHAN, Dongmei , ZHAO, Lianyun
IPC分类号： C07D401/10 , C07D403/10 , C07D417/10 , C07D471/04 , A61K31/513 , A61P33/06
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公开(公告)号：EP4013742A1
公开(公告)日：2022-06-22
申请号：EP20852190.6
申请日：2020-07-21
申请人： Merck Sharp & Dohme Corp. , THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH , MSD R&D (China) Co., Ltd.
发明人： MCCAULEY, John A. , COWMAN, Alan F. , DE LERA RUIZ, Manuel , FAVUZZA, Paola , GUO, Zhuyan , HU, Bin , KELLY III, Michael J. , LEI, Zhiyu , OLSEN, David B. , SLEEBS, Brad , THOMPSON, Jennifer K. , TRIGLIA, Tony , ZHAN, Dongmei , ZHANG, Cailing , ZHAO, Lianyun
IPC分类号： C07D239/22 , C07D405/04 , C07D405/14 , A61K31/513 , A61P33/06
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