公开(公告)号：EP3313852A1

公开(公告)日：2018-05-02

申请号：EP16815100.9

申请日：2016-06-20

申请人： Merck Sharp & Dohme Corp.

发明人： MORRIELLO, Gregori J. ,  CHANG, Lehua ,  FORSTER, Ashley ,  CHEN, Yili ,  DWYER, Michael, P. ,  BERGER, Richard ,  WANG, Ming ,  NANDA, Kausik K. ,  BUNDA, Jaime L. ,  SHIPE, William D.

IPC分类号： C07D498/04 ,  C07D491/04 ,  C07D495/04

CPC分类号： C07D498/04 ,  A61P25/06 ,  A61P25/16 ,  A61P25/18 ,  A61P25/28 ,  C07D473/34 ,  C07D487/04

摘要： The present invention is directed to pyrimidine carboxamide compounds of formula I which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.