公开(公告)号：EP3313852A1

公开(公告)日：2018-05-02

申请号：EP16815100.9

申请日：2016-06-20

申请人： Merck Sharp & Dohme Corp.

发明人： MORRIELLO, Gregori J. ,  CHANG, Lehua ,  FORSTER, Ashley ,  CHEN, Yili ,  DWYER, Michael, P. ,  BERGER, Richard ,  WANG, Ming ,  NANDA, Kausik K. ,  BUNDA, Jaime L. ,  SHIPE, William D.

IPC分类号： C07D498/04 ,  C07D491/04 ,  C07D495/04

CPC分类号： C07D498/04 ,  A61P25/06 ,  A61P25/16 ,  A61P25/18 ,  A61P25/28 ,  C07D473/34 ,  C07D487/04

摘要： The present invention is directed to pyrimidine carboxamide compounds of formula I which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.

公开(公告)号：EP3116862B1

公开(公告)日：2019-04-17

申请号：EP15760695.5

申请日：2015-03-06

申请人： Merck Sharp & Dohme Corp. ,  MSD R & D (China) Co. Ltd.

发明人： WILLIAMS, Peter D. ,  MCCAULEY, John A. ,  BUNGARD, Christopher J. ,  BENNETT, David Jonathan ,  WADDELL, Sherman T. ,  MORRIELLO, Gregori J. ,  CHANG, Lehua ,  DWYER, Michael P. ,  HOLLOWAY, M. Katharine ,  CRESPO, Alejandro ,  CHU, Xin-Jie ,  WISCOUNT, Catherine ,  LOUGHRAN, H. Marie ,  MANIKOWSKI, Jesse J. ,  KEERTIKAR, Kartik M. ,  HU, Bin ,  ZHONG, Bin ,  JI, Tao

IPC分类号： C07D513/08 ,  A61K31/554 ,  A61P31/18

公开(公告)号：EP3116862A1

公开(公告)日：2017-01-18

申请号：EP15760695.5

申请日：2015-03-06

申请人： Merck Sharp & Dohme Corp. ,  MSD R & D (China) Co. Ltd.

发明人： WILLIAMS, Peter D. ,  MCCAULEY, John A. ,  BUNGARD, Christopher J. ,  BENNETT, David Jonathan ,  WADDELL, Sherman T. ,  MORRIELLO, Gregori J. ,  CHANG, Lehua ,  DWYER, Michael P. ,  HOLLOWAY, M. Katharine ,  CRESPO, Alejandro ,  CHU, Xin-Jie ,  WISCOUNT, Catherine ,  LOUGHRAN, H. Marie ,  MANIKOWSKI, Jesse J. ,  KEERTIKAR, Kartik M. ,  HU, Bin ,  ZHONG, Bin ,  JI, Tao

IPC分类号： C07D281/10 ,  C07D241/36

CPC分类号： C07D513/08 ,  A61K31/554 ,  A61K45/06

摘要： The present invention is directed to compounds of Formula I pharmaceutical compositions comprising the same, and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS.

摘要翻译： 本发明涉及式I化合物，包含其的药物组合物，以及它们在抑制HIV蛋白酶，抑制HIV复制，预防HIV感染，治疗HIV感染以及预防， 治疗和延缓艾滋病的发病或进展。

公开(公告)号：EP3027593A2

公开(公告)日：2016-06-08

申请号：EP14832049.2

申请日：2014-07-29

申请人： Merck Sharp & Dohme Corp. ,  MSD R & D (China) Co. Ltd.

发明人： WILLIAMS, Peter D. ,  MCCAULEY, John A. ,  BENNETT, David J. ,  BUNGARD, Christopher J. ,  CHANG, Lehua ,  CHU, Xin-Jie ,  DWYER, Michael P. ,  HOLLOWAY, M. Katherine ,  KEERTIKAR, Kartik M. ,  LOUGHRAN, H. Marie ,  MANIKOWSKI, Jesse J. ,  MORRIELLO, Gregori J. ,  SHEN, Dong-Ming ,  SHERER, Edward C. ,  SCHULZ, Jurgen ,  WADDELL, Sherman Tim ,  WISCOUNT, Catherine M. ,  ZORN, Nicolas ,  SATYANARAYANA, Tummanapalli ,  VIJAYASARADHI, Sivalenka ,  HU, Bin ,  JI, Tao ,  ZHONG, Bin

IPC分类号： C07D295/088

CPC分类号： C07D241/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

摘要： The present invention is directed to piperazine derivatives, pharmaceutical compositions comprising the same, and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS.

摘要翻译： 本发明涉及哌嗪衍生物，包含它们的药物组合物及其在抑制HIV蛋白酶中的用途，HIV复制的抑制，HIV预防感染，HIV感染治疗以及预防，治疗 ，并延迟艾滋病的发病或进展。