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公开(公告)号：EP3104703A1
公开(公告)日：2016-12-21
申请号：EP15748866.9
申请日：2015-02-06
发明人： NEELAMKAVIL, Santhosh F. , EDMONDSON, Scott D. , HRUZA, Alan W. , HUSSAIN, Zahid , LESBURG, Charles , MONINGKA, Remond
IPC分类号： A01N37/12
CPC分类号： C07D471/08 , C07D487/08
摘要： The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
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公开(公告)号：EP3134408A1
公开(公告)日：2017-03-01
申请号：EP15783339.3
申请日：2015-04-21
发明人： LIM, Yeon-Hee , GUO, Zhuyan , ALI, Amjad , EDMONDSON, Scott D. , LIU, Weiguo , GALLO-ETIENNE, Gioconda V. , WU, Heping , GAO, Ying-Duo , STAMFORD, Andrew M. , YU, Younong , KEVIN, Nancy J. , ANAND, Rajan , SHA, Deyou , NEELAMKAVIL, Santhosh F. , HUSSAIN, Zahid , KUMAR, Puneet , MONINGKA, Remond , DUFFY, Joseph L. , XU, Jiayi , JIANG, Yu , SONE, Hiroki , CHAKRABARTI, Anjan
IPC分类号： C07D471/10 , A61K31/438 , C07D498/20
CPC分类号： C07D498/20 , C07D471/10 , C07D487/10 , C07D498/10 , C07F9/6561
摘要： The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
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公开(公告)号：EP3134408B1
公开(公告)日：2020-08-12
申请号：EP15783339.3
申请日：2015-04-21
发明人： LIM, Yeon-Hee , GUO, Zhuyan , ALI, Amjad , EDMONDSON, Scott D. , LIU, Weiguo , GALLO-ETIENNE, Gioconda V. , WU, Heping , GAO, Ying-Duo , STAMFORD, Andrew M. , YU, Younong , KEVIN, Nancy J. , ANAND, Rajan , SHA, Deyou , NEELAMKAVIL, Santhosh F. , HUSSAIN, Zahid , KUMAR, Puneet , MONINGKA, Remond , DUFFY, Joseph L. , XU, Jiayi , JIANG, Yu , SONE, Hiroki , CHAKRABARTI, Anjan
IPC分类号： C07D471/10 , A61K31/438 , C07D498/20
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公开(公告)号：EP3104701A1
公开(公告)日：2016-12-21
申请号：EP15748475.9
申请日：2015-02-06
发明人： NEELAMKAVIL, Santhosh F. , EDMONDSON, Scott D. , GUO, Zhuyan , HRUZA, Alan W. , HUSSAIN, Zahid , LESBURG, Charles A. , MONINGKA, Remond , OGAWA, Anthony K. , MAL, Rudrajit
IPC分类号： A01N37/12
CPC分类号： C07D487/08 , C07D471/08
摘要： The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
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公开(公告)号：EP3104703B1
公开(公告)日：2020-11-18
申请号：EP15748866.9
申请日：2015-02-06
发明人： NEELAMKAVIL, Santhosh F. , EDMONDSON, Scott D. , HRUZA, Alan W. , HUSSAIN, Zahid , LESBURG, Charles , MONINGKA, Remond
IPC分类号： C07D471/08 , C07D487/08
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公开(公告)号：EP3104701B1
公开(公告)日：2019-01-30
申请号：EP15748475.9
申请日：2015-02-06
发明人： NEELAMKAVIL, Santhosh F. , EDMONDSON, Scott D. , GUO, Zhuyan , HRUZA, Alan W. , HUSSAIN, Zahid , LESBURG, Charles A. , MONINGKA, Remond , OGAWA, Anthony K. , MAL, Rudrajit
IPC分类号： A01N37/12 , C07D471/08 , C07D487/08 , A61P7/02 , A61K31/439
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公开(公告)号：EP3283464A1
公开(公告)日：2018-02-21
申请号：EP16780505.0
申请日：2016-04-11
发明人： MERTZ, Eric , EDMONDSON, Scott D. , SO, Sung-Sau , SUN, Wanying , LIU, Weiguo , NEELAMKAVIL, Santhosh F. , GAO, Ying-Duo , HRUZA, Alan , ZANG, Yi , ALI, Amjad , MAL, Rudrajit , HE, Jiafang , KUANG, Rongze , WU, Heping , OGAWA, Anthony K. , NOLTING, Andrew F.
IPC分类号： C07D233/68 , A61K31/426 , A61K31/4178 , A61P9/00 , C07D241/00
CPC分类号： C07D401/14 , C07D409/14 , C07D413/14
摘要： The present invention provides a compound of Formula (I); and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
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