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公开(公告)号：EP3883576A1
公开(公告)日：2021-09-29
申请号：EP19887235.0
申请日：2019-11-15
发明人： BRILL, Zachary, G. , ALI, Amjad , CUMMING, Jared , DEMONG, Duane , DENG, Qiaolin , GALLO-ETIENNE, Gioconda, V. , GRAHAM, Thomas, H. , KUANG, Rongze , LARSEN, Matthew, A. , LIM, Yeon-Hee , LIU, Kun , MANSOOR, Umar Faruk , MORENO, Jesus , VARA, Brandon, A. , WANG, Huijun , ZHANG, Yonglian
IPC分类号： A61K31/519 , A61K31/4985 , C07D487/04
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公开(公告)号：EP3870171A1
公开(公告)日：2021-09-01
申请号：EP19875689.2
申请日：2019-10-21
发明人： ALI, Amjad , DEBENHAM, John, S. , ZHU, Cheng
IPC分类号： A61K31/4427 , C07D213/89 , C07D401/04 , C07D401/14
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公开(公告)号：EP3247354B1
公开(公告)日：2019-08-07
申请号：EP16740526.5
申请日：2016-01-15
发明人： MERTZ, Eric , LIU, Weiguo , EDMONDSON, Scott, D. , ALI, Amjad , GAO, Ying-Duo , NEELAMKAVIL, Santhosh, F. , SO, Sung-Sau , MONINGKA, Remond , SUN, Wanying , HRUZA, Alan , BROCKUNIER, Linda, L.
IPC分类号： A61K31/4375 , A61P7/02 , A61P7/04
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公开(公告)号：EP3331532A1
公开(公告)日：2018-06-13
申请号：EP16824890.4
申请日：2016-07-05
发明人： ALI, Amjad , HUANG, Xianhai , KUANG, Rongze , LIM, Yeon-Hee , WU, Heping , ANAND, Rajan , YU, Younong , METZGER, Edward , LO, Michael Man-Chu , TING, Pauline , STAMFORD, Andrew, W. , TEMPEST, Paul
IPC分类号： A61K31/535
CPC分类号： C07D487/04 , C07D491/153
摘要： The present invention is directed to compounds of generic formula (I): or pharmaceutically acceptable salts thereof that are believed to be useful as an A2A-receptor antagonist. The invention is further directed to methods of treating a patient (preferably a human) for diseases or disorders in which the A2A-receptor is involved. The invention further involves use of the compounds as an A2A-receptor antagonist and/or inhibitor for the preparation of a medicament for the treatment and/or prevention of diseases associated with inhibiting the receptor, which includes central nervous system disorders such as Parkinson's disease. The invention is also directed to pharmaceutical compositions which include an effective amount of a compound of formula (I), or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, and the use of the compounds and pharmaceutical compositions of the invention in the treatment of such diseases.
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公开(公告)号：EP3180317A1
公开(公告)日：2017-06-21
申请号：EP15826790.6
申请日：2015-07-23
发明人： LIU, Weiguo , EDMONDSON, Scott D. , GUO, Zhuyan , SO, Sung-Sau , OGAWA, Anthony K. , KUANG, Rongze , WU, Heping , ALI, Amjad , GAO, Ying-Duo , JIANG, Yu , LI, Chunsing , YU, Tingting , PANDYA, Bhuamik , LIPPA, Blaise , ZHANG, Xin , BABER, Jon Christian , ROMERO, Jan Antoinette C. , ZHANG, Jing
IPC分类号： C07D233/54 , C07D257/06 , C07D263/30 , C07D249/06 , C07D285/04 , C07D271/10 , A61K31/4164 , A61K31/4192 , A61K31/422 , A61K31/433 , A61P7/02
CPC分类号： C07D409/14 , A61P7/02 , C07D401/06 , C07D401/14 , C07D413/14 , C07D417/14
摘要： The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
摘要翻译： 本发明提供式（I）的化合物和包含一种或多种所述化合物的药物组合物，以及使用所述化合物治疗或预防血栓形成，栓塞，高凝状态或纤维变化的方法。 这些化合物是选择性因子XIa抑制剂或因子XIa和血浆激肽释放酶的双重抑制剂。
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6.发明授权
公开(公告)号：EP2683687B1
公开(公告)日：2017-04-19
申请号：EP12709453.0
申请日：2012-03-05
发明人： SHAH, Shrenik, K. , ALI, Amjad , LO, Michael Man-Chu , WHITEHEAD, Brent , HENDERSON, Timothy, J. , YAN, Lin , GUO, Zhiqiang
IPC分类号： C07D207/12 , C07D207/48 , C07D211/46 , C07D211/96 , C07D223/08 , C07D309/12 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/12 , C07D207/273 , A61K31/445
CPC分类号： C07D211/46 , C07D207/12 , C07D207/273 , C07D207/48 , C07D211/96 , C07D223/08 , C07D309/12 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/12
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公开(公告)号：EP3134408A1
公开(公告)日：2017-03-01
申请号：EP15783339.3
申请日：2015-04-21
发明人： LIM, Yeon-Hee , GUO, Zhuyan , ALI, Amjad , EDMONDSON, Scott D. , LIU, Weiguo , GALLO-ETIENNE, Gioconda V. , WU, Heping , GAO, Ying-Duo , STAMFORD, Andrew M. , YU, Younong , KEVIN, Nancy J. , ANAND, Rajan , SHA, Deyou , NEELAMKAVIL, Santhosh F. , HUSSAIN, Zahid , KUMAR, Puneet , MONINGKA, Remond , DUFFY, Joseph L. , XU, Jiayi , JIANG, Yu , SONE, Hiroki , CHAKRABARTI, Anjan
IPC分类号： C07D471/10 , A61K31/438 , C07D498/20
CPC分类号： C07D498/20 , C07D471/10 , C07D487/10 , C07D498/10 , C07F9/6561
摘要： The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
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公开(公告)号：EP1954287B2
公开(公告)日：2016-02-24
申请号：EP06826999.2
申请日：2006-10-30
发明人： ALI, Amjad , HUNT, Julianne, A. , KALLASHI, Florida , KOWALCHICK, Jennifer, E. , KIM, Dooseop , SMITH, Cameron, J. , SINCLAIR, Peter, J. , SWEIS, Ramzi, F. , TAYLOR, Gayle, E. , THOMPSON, Christopher, F. , CHEN, Liya , QURAISHI, Nazia
IPC分类号： A61K31/41
CPC分类号： C07D263/57 , C07D235/18 , C07D239/74 , C07D277/64 , C07D277/66 , C07D413/04 , C07D413/10 , C07D413/12 , C07D413/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D495/10 , C07D498/04
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9.发明公开HETEROBICYCLO-SUBSTITUTED-[1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES 有权HETEROBCYCLOSUBSTITUIERTE [1,2,4]三唑并[1,5-C]喹唑啉-5-胺化合物A2A拮抗性能
公开(公告)号：EP2945632A1
公开(公告)日：2015-11-25
申请号：EP13866588.0
申请日：2013-12-20
发明人： ALI, Amjad , LO, Michael Man-Chu , LIM, Yeon-Hee , STAMFORD, Andrew , KUANG, Rongze , TEMPEST, Paul , YU, Younong , HUANG, Xianhai , HENDERSON, Timothy, J. , KIM, Jae-Hun , BOYCE, Christopher , TING, Pauline , ZHENG, Junying , METZGER, Edward , ZORN, Nicolas , XIAO, Dong , GALLO, Gioconda, V. , WON, Walter , WU, Heping , DENG, Qiaolin
IPC分类号： A61K31/4985 , A61K31/519 , C07D487/04 , A61P25/16
CPC分类号： C07D519/00 , C07D487/04
摘要： Disclosed are compounds of Formula Gl (structurally represented): where "RG3" "Rd1" to "Rd4", "n", "m", "p", "W", "X", "Y", and "Z" are defined herein which compounds are antagonists of A2A receptor. Disclosed herein also are uses of the compounds described herein as antagonists of the A2a receptor in the potential treatment or prevention of neurological disorders and diseases in which A2A receptors are involved. Disclosed herein also are pharmaceutical compositions comprising these compounds and uses of these pharmaceutical compositions.
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公开(公告)号：EP2485734B1
公开(公告)日：2014-07-02
申请号：EP10822415.5
申请日：2010-09-20
发明人： ALI, Amjad , LO, Michael, Man-Chu , YAN, Lin
IPC分类号： A61K31/535 , C07D491/04
CPC分类号： C07D491/04
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