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公开(公告)号：EP3134408A1
公开(公告)日：2017-03-01
申请号：EP15783339.3
申请日：2015-04-21
发明人： LIM, Yeon-Hee , GUO, Zhuyan , ALI, Amjad , EDMONDSON, Scott D. , LIU, Weiguo , GALLO-ETIENNE, Gioconda V. , WU, Heping , GAO, Ying-Duo , STAMFORD, Andrew M. , YU, Younong , KEVIN, Nancy J. , ANAND, Rajan , SHA, Deyou , NEELAMKAVIL, Santhosh F. , HUSSAIN, Zahid , KUMAR, Puneet , MONINGKA, Remond , DUFFY, Joseph L. , XU, Jiayi , JIANG, Yu , SONE, Hiroki , CHAKRABARTI, Anjan
IPC分类号： C07D471/10 , A61K31/438 , C07D498/20
CPC分类号： C07D498/20 , C07D471/10 , C07D487/10 , C07D498/10 , C07F9/6561
摘要： The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
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公开(公告)号：EP3134408B1
公开(公告)日：2020-08-12
申请号：EP15783339.3
申请日：2015-04-21
发明人： LIM, Yeon-Hee , GUO, Zhuyan , ALI, Amjad , EDMONDSON, Scott D. , LIU, Weiguo , GALLO-ETIENNE, Gioconda V. , WU, Heping , GAO, Ying-Duo , STAMFORD, Andrew M. , YU, Younong , KEVIN, Nancy J. , ANAND, Rajan , SHA, Deyou , NEELAMKAVIL, Santhosh F. , HUSSAIN, Zahid , KUMAR, Puneet , MONINGKA, Remond , DUFFY, Joseph L. , XU, Jiayi , JIANG, Yu , SONE, Hiroki , CHAKRABARTI, Anjan
IPC分类号： C07D471/10 , A61K31/438 , C07D498/20
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公开(公告)号：EP2770998A1
公开(公告)日：2014-09-03
申请号：EP12843432.1
申请日：2012-10-24
IPC分类号： A61K31/4412
CPC分类号： C07D401/12 , A61K31/4375 , A61K31/4439 , A61K31/4725 , A61K31/5377 , A61K45/06 , C07D413/12 , C07D413/14 , C07D471/04
摘要： The present invention provides a compound of Formula (I) as described herein, or a pharmaceutically acceptable salt thereof. The present invention also provides pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing a thromboses, embolisms, hypercoagulability or fibrotic changes.
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