公开(公告)号：EP2059519B1

公开(公告)日：2013-12-18

申请号：EP07861898.0

申请日：2007-11-09

申请人： Merck Sharp & Dohme Corp.

发明人： PALANI, Anandan ,  SU, Jing ,  XIAO, Dong ,  HUANG, Xianhai ,  RAO, Ashwin U. ,  CHEN, Xiao ,  TANG, Haiqun ,  QIN, Jun ,  HUANG, Ying R. ,  ASLANIAN, Robert G. ,  MCKITTRICK, Brian A. ,  DEGRADO, Sylvia J.

IPC分类号： C07D471/04 ,  C07D491/04 ,  A61K31/519 ,  A61P3/00 ,  A61P9/00

CPC分类号： C07D491/04 ,  C07D471/04

摘要： The present invention provides compounds of Formula (I) and pharmaceutica lly acceptable salts, solvates, esters, and tautomers thereof, wherein: Q is selected from the group consisting of: (a), (b), (c), (d) and (e); and L is selected from the group consisting of: (f), (g), (h), and (i); pharmaceutic ally compositions comprising one or more compounds of formula (I), and metho ds of using the compounds of formula (I).