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公开(公告)号：EP2661428B1
公开(公告)日：2017-06-07
申请号：EP11851281.3
申请日：2011-12-19
发明人： BOYCE, Christopher W. , DEGRADO, Sylvia Joanna , CHEN, Xiao , QIN, Jun , MAZZOLA, Robert D., Jr. , YU, Younong , MCCORMIC, Kevin D. , PALANI, Anandan , XIAO, Dong , ASLANIAN, Robert George , WU, Jie , RAO, Ashwin Umesh , SILIPHAIVANH, Phieng , METHOD, Joe Lee , ZHANG, Hongjun , KELLEY, Elizabeth Helen , BROWN, William Colby , JIANG, Qin , GAUUAN, Jolicia Polivina , LEYHANE, Andrew J. , BIJU, Purakkattle Johny , DHONDI, Pawan K. , DONG, Li , FEVRIER, Salem , HUANG, Xianhai , VACCARO, Henry M.
IPC分类号： C07D241/42 , C07D241/44 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/12 , C07D417/14 , C07D471/04 , C07D471/08 , C07D487/04 , C07D487/08 , C07D498/04 , A61K31/498 , A61P11/02 , A61P11/06 , A61P11/14
CPC分类号： C07D241/42 , A61K31/498 , A61K31/4985 , A61K31/506 , A61K31/55 , A61K45/06 , C07D241/38 , C07D241/44 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D451/02 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/08 , C07D491/048 , C07D491/107 , C07D498/04 , C07D498/10
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公开(公告)号：EP2512238B1
公开(公告)日：2014-06-25
申请号：EP10838138.5
申请日：2010-12-09
发明人： XIAO, Dong , PALANI, Anandan , ASLANIAN, Robert, G. , DEGRADO, Sylvia , HUANG, Xianhai , ZHOU, Wei , SOFOLARIDES, Michael , CHEN, Xiao
IPC分类号： A61K31/55 , C07D491/048 , C07D495/04 , A61P29/00
CPC分类号： A61K31/55 , C07D491/048 , C07D495/04
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公开(公告)号：EP2059519B1
公开(公告)日：2013-12-18
申请号：EP07861898.0
申请日：2007-11-09
发明人： PALANI, Anandan , SU, Jing , XIAO, Dong , HUANG, Xianhai , RAO, Ashwin U. , CHEN, Xiao , TANG, Haiqun , QIN, Jun , HUANG, Ying R. , ASLANIAN, Robert G. , MCKITTRICK, Brian A. , DEGRADO, Sylvia J.
IPC分类号： C07D471/04 , C07D491/04 , A61K31/519 , A61P3/00 , A61P9/00
CPC分类号： C07D491/04 , C07D471/04
摘要： The present invention provides compounds of Formula (I) and pharmaceutica lly acceptable salts, solvates, esters, and tautomers thereof, wherein: Q is selected from the group consisting of: (a), (b), (c), (d) and (e); and L is selected from the group consisting of: (f), (g), (h), and (i); pharmaceutic ally compositions comprising one or more compounds of formula (I), and metho ds of using the compounds of formula (I).
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4.发明公开
公开(公告)号：EP2661428A1
公开(公告)日：2013-11-13
申请号：EP11851281.3
申请日：2011-12-19
发明人： BOYCE, Christopher W. , DEGRADO, Sylvia Joanna , CHEN, Xiao , QIN, Jun , MAZZOLA, Robert D Jr. , YU, Younong , MCCORMIC, Kevin D , PALANI, Anandan , XIAO, Dong , ASLANIAN, Robert George , WU, Jie , RAO, Ashwin Umesh , SILIPHAIVANH, Phieng , METHOD, Joe Lee , ZHANG, Hongjun , KELLEY, Elizabeth Helen , BROWN, William Colby , JIANG, Qin , GAUUAN, Jolicia Polivina , LEYHANE, Andrew J. , BIJU, Purakkattle Johny , DHONDI, Pawan K. , DONG, Li , FEVRIER, Salem , HUANG, Xianhai , VACCARO, Henry M.
IPC分类号： C07D241/36 , A61K31/498
CPC分类号： C07D241/42 , A61K31/498 , A61K31/4985 , A61K31/506 , A61K31/55 , A61K45/06 , C07D241/38 , C07D241/44 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D451/02 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/08 , C07D491/048 , C07D491/107 , C07D498/04 , C07D498/10
摘要： The invention provides certain quinoxalines and aza-quinoxalines of the Formula (I), and their pharmaceutically acceptable salts, wherein J
1 , J
2 , R
1 , R
2 , R
3 , R
22 , R
a , R
b , R
c , R
d , X, Y, b, n, and q are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions associated with with uncontrolled or inappropriate stimulation of CRTH
2 function.-
公开(公告)号：EP2512238A1
公开(公告)日：2012-10-24
申请号：EP10838138.5
申请日：2010-12-09
发明人： XIAO, Dong , PALANI, Anandan , ASLANIAN, Robert, G. , DEGRADO, Sylvia , HUANG, Xianhai , ZHOU, Wei , SOFOLARIDES, Michael , CHEN, Xiao
CPC分类号： A61K31/55 , C07D491/048 , C07D495/04
摘要： The present invention relates to certain lactam ring-containing compounds of the Formula (I) and pharmaceutically acceptable salts thereof, wherein D, E, X1, R1, R2, R3, R4, R9, and R10 are as herein described. In addition, the invention relates to pharmaceutically acceptable compositions comprising at least one such compound, and methods of using the compounds for treating or preventing various inflammatory disorders such as rheumatoid arthritis, inflammatory bowel disease, psoriasis, asthma, and chronic obstructive pulmonary disorder.
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6.发明授权ORTHO-CONDENSED 2-PYRIDINONE DERIVATIVES AS NICOTINIC ACID RECEPTOR AGONISTS FOR THE TREATMENT OF DYSLIPIDEMIA 有权ORTHO简明2 PYRIDINONDERIVATE烟碱酸受体用于治疗血脂异常激动剂
公开(公告)号：EP1885726B1
公开(公告)日：2016-12-14
申请号：EP06759539.7
申请日：2006-05-11
发明人： PALANI, Anandan , SU, Jing , XIAO, Dong , HUANG, Xianhai , RAO, Ashwin, U. , CHEN, Xiao , TANG, Haiqun , QIN, Jun , HUANG, Ying , ASLANIAN, Robert, G. , MCKITTRICK, Brian
IPC分类号： C07D491/04
CPC分类号： C07D471/04 , C07D491/04 , C07D491/052
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