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公开(公告)号：EP2951180B1
公开(公告)日：2018-05-02
申请号：EP14745870.7
申请日：2014-01-29
发明人： CAMMARANO, Carolyn Michele , CHRISTOPHER, Matthew, P. , DINSMORE, Christopher , DOLL, Ronald, J. , FRADERA LLINAS, Francesc Xavier , LI, Chaomin , MACHACEK, Michelle , MARTINEZ, Michelle , NAIR, Latha, G. , PAN, Weidong , REUTERSHAN, Michael Hale , SHIZUKA, Manami , STEINHUEBEL, Dietrich, P. , SUN, Binyuan , THOMPSON, Christopher Francis , TROTTER, B. Wesley , VOSS, Matthew Ernst , WANG, Yaolin , YANG, Liping , PANDA, Jagannath , KURISSERY, Anthappan Tony , BOGEN, Stephane, L.
IPC分类号： C07D473/00 , C07D473/16 , C07D473/30 , C07D473/34 , A61K31/52 , A61P35/00
CPC分类号： C07D473/00 , C07D473/16 , C07D473/30 , C07D473/34
摘要： The present invention provides 2,6,7,8 Substituted Purines as described herein or a pharmaceutically acceptable salt thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.
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公开(公告)号：EP3706742A1
公开(公告)日：2020-09-16
申请号：EP18875596.1
申请日：2018-11-05
发明人： MACHACEK, Michelle, R. , WITTER, David, J. , REUTERSHAN, Michael Hale , ALTMAN, Michael, D. , STUPPLE, Paul Anthony
IPC分类号： A61K31/4375 , C07D217/16 , C07D401/02
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公开(公告)号：EP2934535A2
公开(公告)日：2015-10-28
申请号：EP13865881.0
申请日：2013-12-18
发明人： DINSMORE, Christopher , FRADERA LLINAS, Francesc Xavier , KUDALE, Amit Ashokrao , REUTERSHAN, Michael Hale , THOMPSON, Christopher Francis , YANG, Liping , ALTMAN, Michael, D. , BOGEN, Stephane, L. , DOLL, Ronald, J. , VOSS, Matthew, E.
IPC分类号： A61K31/519
CPC分类号： C07D487/04
摘要： The present invention provides substituted pyrrolopyrimidines as described herein or a pharmaceutically acceptable salt or solvate thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.
摘要翻译： 本发明提供如本文所述的取代的吡咯并嘧啶或其药学上可接受的盐或溶剂化物。 代表性化合物可用作HDM2蛋白的抑制剂。 还公开了包含上述化合物的药物组合物和使用其治疗癌症的潜在方法。
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公开(公告)号：EP3706747A1
公开(公告)日：2020-09-16
申请号：EP18876835.2
申请日：2018-11-05
发明人： MACHACEK, Michelle, R. , WITTER, David, J. , REUTERSHAN, Michael Hale , SLOMAN, David, L. , ALTMAN, Michael, D.
IPC分类号： A61K31/4725 , C07D401/14
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公开(公告)号：EP2935263B1
公开(公告)日：2018-12-05
申请号：EP13818899.0
申请日：2013-12-18
发明人： BOLISETTI, Raghu , CAMMARANO, Carolyn Michele , CHRISTOPHER, Matthew, P. , FRADERA LLINAS, Francesc Xavier , GHOSH, Partha , MACHACEK, Michelle , MARTINEZ, Michelle , PANDA, Jagannath , REUTERSHAN, Michael Hale , SAMALA, Jaya Prakash , SHIZUKA, Manami , SUN, Binyuan , THOMPSON, Christopher Francis , TONY KURISSERY, Anthappan , TROTTER, B. Wesley , VOSS, Matthew, E. , YANG, Liping , ALTMAN, Michael, D. , BOGEN, Stephane, L. , DOLL, Ronald, J.
IPC分类号： C07D471/08 , C07D471/04 , C07D519/00 , A61K31/437 , A61K31/498 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/553 , A61K31/541 , A61P35/00 , C07D498/04
CPC分类号： C07D471/04 , C07D471/08 , C07D498/04 , C07D519/00
摘要： The present invention provides substituted imidazopyridines as described herein or a pharmaceutically acceptable salt or solvate thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.
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公开(公告)号：EP2953470A1
公开(公告)日：2015-12-16
申请号：EP14749379.5
申请日：2014-02-04
发明人： CHRISTOPHER, Matthew, P. , FRADERA LLINAS, Francesc Xavier , MACHACEK, Michelle , MARTINEZ, Michelle , REUTERSHAN, Michael Hale , SHIZUKA, Manami , SUN, Binyuan , THOMPSON, Christopher Francis , TROTTER, B. Wesley , VOSS, Matthew, E. , YANG, Liping
IPC分类号： A01N43/90 , A61K31/52 , A61K31/535 , C07D413/00
CPC分类号： C07D473/34 , C07D473/00 , C07D473/30
摘要： The present invention provides 2,6,7 substituted purines as described herein or a pharmaceutically acceptable salt thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.
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公开(公告)号：EP2935263A1
公开(公告)日：2015-10-28
申请号：EP13818899.0
申请日：2013-12-18
发明人： BOLISETTI, Raghu , CAMMARANO, Carolyn Michele , CHRISTOPHER, Matthew, P. , FRADERA LLINAS, Francesc Xavier , GHOSH, Partha , MACHACEK, Michelle , MARTINEZ, Michelle , PANDA, Jagannath , REUTERSHAN, Michael Hale , SAMALA, Jaya Prakash , SHIZUKA, Manami , SUN, Binyuan , THOMPSON, Christopher Francis , TONY KURISSERY, Anthappan , TROTTER, B. Wesley , VOSS, Matthew, E. , YANG, Liping , ALTMAN, Michael, D. , BOGEN, Stephane, L. , DOLL, Ronald, J.
IPC分类号： C07D471/04 , C07D519/00 , A61K31/437 , A61K31/498 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/553 , A61K31/541 , A61P35/00
CPC分类号： C07D471/04 , C07D471/08 , C07D498/04 , C07D519/00
摘要： The present invention provides substituted imidazopyridines as described herein or a pharmaceutically acceptable salt or solvate thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.
摘要翻译： 本发明提供如本文所述的取代的咪唑并吡啶或其药学上可接受的盐或溶剂化物。 代表性化合物可用作HDM2蛋白的抑制剂。 还公开了包含上述化合物的药物组合物和使用其治疗癌症的潜在方法。
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公开(公告)号：EP2953470B1
公开(公告)日：2020-01-22
申请号：EP14749379.5
申请日：2014-02-04
发明人： CHRISTOPHER, Matthew, P. , FRADERA LLINAS, Francesc Xavier , MACHACEK, Michelle , MARTINEZ, Michelle , REUTERSHAN, Michael Hale , SHIZUKA, Manami , SUN, Binyuan , THOMPSON, Christopher Francis , TROTTER, B. Wesley , VOSS, Matthew, E. , YANG, Liping
IPC分类号： C07D473/00 , C07D473/30 , C07D473/34
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公开(公告)号：EP2934535B1
公开(公告)日：2017-07-19
申请号：EP13865881.0
申请日：2013-12-18
发明人： DINSMORE, Christopher , FRADERA LLINAS, Francesc Xavier , KUDALE, Amit Ashokrao , REUTERSHAN, Michael Hale , THOMPSON, Christopher Francis , YANG, Liping , ALTMAN, Michael, D. , BOGEN, Stephane, L. , DOLL, Ronald, J. , VOSS, Matthew, E.
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04
摘要： The present invention provides substituted pyrrolopyrimidines as described herein or a pharmaceutically acceptable salt or solvate thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.
摘要翻译： 本发明提供如本文所述的取代的吡咯并嘧啶或其药学上可接受的盐或溶剂化物。 代表性化合物可用作HDM2蛋白的抑制剂。 还公开了包含上述化合物和使用其治疗癌症的潜在方法的药物组合物。
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公开(公告)号：EP2951180A1
公开(公告)日：2015-12-09
申请号：EP14745870.7
申请日：2014-01-29
发明人： CAMMARANO, Carolyn Michele , CHRISTOPHER, Matthew, P. , DINSMORE, Christopher , DOLL, Ronald, J. , FRADERA LLINAS, Francesc Xavier , LI, Chaomin , MACHACEK, Michelle , MARTINEZ, Michelle , NAIR, Latha, G. , PAN, Weidong , REUTERSHAN, Michael Hale , SHIZUKA, Manami , STEINHUEBEL, Dietrich, P. , SUN, Binyuan , THOMPSON, Christopher Francis , TROTTER, B. Wesley , VOSS, Matthew Ernst , WANG, Yaolin , YANG, Liping , PANDA, Jagannath , KURISSERY, Anthappan Tony , BOGEN, Stephane, L.
IPC分类号： C07D473/34
CPC分类号： C07D473/00 , C07D473/16 , C07D473/30 , C07D473/34
摘要： The present invention provides 2,6,7,8 Substituted Purines as described herein or a pharmaceutically acceptable salt thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.
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