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1.发明公开BICYCLOAMINE-SUBSTITUTED-N-BENZENESULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS 审中-公开选择性活动BICYCLOAMINSUBSTITUIERTE的N-苯磺酰胺压控钠通道
公开(公告)号：EP3074402A1
公开(公告)日：2016-10-05
申请号：EP14866477.4
申请日：2014-11-24
发明人： LI, Dansu , LAYTON, Mark E. , ROECKER, Anthony J. , EGBERTSON, Melissa , JONES, Kristen L. G. , WANG, Xiu , PENG, Xuanjia
IPC分类号： C07D487/04
CPC分类号： C07D487/04 , C07D213/76 , C07D237/20 , C07D239/42 , C07D277/52 , C07D285/135 , C07D471/04 , C07D487/10 , C07D491/20
摘要： Disclosed are compounds of Formula A-a, or a salt thereof: Where "B
1 " and "R
1 " through "R
5 " are as defined herein, which compounds have properties for blocking Na
v 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A-a or their salts, and methods of treating neuropathic pain disorders using the same.-
公开(公告)号：EP3074402B1
公开(公告)日：2019-01-16
申请号：EP14866477.4
申请日：2014-11-24
发明人： LI, Dansu , LAYTON, Mark E. , ROECKER, Anthony J. , EGBERTSON, Melissa , JONES, Kristen L. G. , WANG, Xiu , PENG, Xuanjia
IPC分类号： C07D487/04 , C07D491/20 , C07D471/04 , C07D455/02 , A61K31/433 , A61K31/427 , A61K31/4439 , A61K31/506 , A61K31/501 , A61K31/437 , A61K31/4375 , A61P25/02
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3.发明授权
公开(公告)号：EP2089382B1
公开(公告)日：2012-10-24
申请号：EP07862400.4
申请日：2007-11-30
发明人： BERGMAN, Jeffrey M. , BRESLIN, Michael J. , COLEMAN, Paul J. , COX, Christopher D. , MERCER, Swati P. , ROECKER, Anthony J.
IPC分类号： C07D401/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D491/048 , C07D491/052 , C07D495/04 , A61K31/551 , A61P3/04 , A61P25/20 , C07D403/14
CPC分类号： C07D413/14 , C07D401/14 , C07D403/14 , C07D471/04 , C07D487/04 , C07D491/048 , C07D491/052 , C07D495/04
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