公开(公告)号：EP2512243B1

公开(公告)日：2016-04-06

申请号：EP10841821.1

申请日：2010-12-13

申请人： Merck Sharp & Dohme Corp.

发明人： KUDUK, Scott, D. ,  SCHLEGEL, Kelly-Ann ,  YANG, Zhi-Qiang

IPC分类号： C07D413/10 ,  C07D401/04 ,  C07D401/10 ,  C07D417/10 ,  C07D215/48 ,  C07D215/60 ,  C07D401/06 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/06 ,  C07D413/14 ,  C07D417/14

CPC分类号： C07D215/60 ,  C07D215/48 ,  C07D401/04 ,  C07D401/06 ,  C07D401/10 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/06 ,  C07D413/10 ,  C07D413/14 ,  C07D417/10 ,  C07D417/14 ,  C07D471/04

公开(公告)号：EP2493297A1

公开(公告)日：2012-09-05

申请号：EP10827361.6

申请日：2010-10-25

申请人： Merck Sharp & Dohme Corp.

发明人： SCHLEGEL, Kelly-Ann ,  SHU, Yoheng ,  YANG, Zhi-Qiang ,  BARROW, James

IPC分类号： A01N37/12 ,  A01N37/18 ,  A61K31/16

CPC分类号： C07D401/06 ,  C07D233/64 ,  C07D249/04 ,  C07D257/04 ,  C07D263/32 ,  C07D271/10 ,  C07D271/113 ,  C07D277/28 ,  C07D413/04 ,  C07D413/06 ,  C07D417/14

摘要： The present invention is directed to heterocycle amide compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels are involved.

公开(公告)号：EP2493297B1

公开(公告)日：2016-08-17

申请号：EP10827361.6

申请日：2010-10-25

申请人： Merck Sharp & Dohme Corp.

发明人： SCHLEGEL, Kelly-Ann ,  SHU, Yoheng ,  YANG, Zhi-Qiang ,  BARROW, James

IPC分类号： A01N37/12 ,  A01N37/18 ,  A61K31/16 ,  C07D233/64 ,  C07D249/04 ,  C07D257/04 ,  C07D271/10 ,  C07D277/28 ,  C07D401/06 ,  C07D413/04 ,  C07D413/06 ,  C07D417/14 ,  C07D271/113 ,  A61K31/41 ,  A61K31/4164 ,  A61K31/4192 ,  A61K31/421 ,  A61K31/427 ,  A61K31/4439 ,  C07D263/32 ,  A61K31/4245

CPC分类号： C07D401/06 ,  C07D233/64 ,  C07D249/04 ,  C07D257/04 ,  C07D263/32 ,  C07D271/10 ,  C07D271/113 ,  C07D277/28 ,  C07D413/04 ,  C07D413/06 ,  C07D417/14

公开(公告)号：EP2512243A1

公开(公告)日：2012-10-24

申请号：EP10841821.1

申请日：2010-12-13

申请人： Merck Sharp & Dohme Corp.

发明人： KUDUK, Scott, D. ,  SCHLEGEL, Kelly-Ann ,  YANG, Zhi-Qiang

IPC分类号： A01N43/42 ,  A61K31/47

CPC分类号： C07D215/60 ,  C07D215/48 ,  C07D401/04 ,  C07D401/06 ,  C07D401/10 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/06 ,  C07D413/10 ,  C07D413/14 ,  C07D417/10 ,  C07D417/14 ,  C07D471/04

摘要： The present invention is directed to quinoline amide compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.