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公开(公告)号：EP2303885A1
公开(公告)日：2011-04-06
申请号：EP09763288.9
申请日：2009-06-02
发明人： FURUKAWA, Shuntaro , IKENO, Taketo , KATO, Shinji , KAWASAKI, Masashi , KOJIMA, Hisaki , MINAGAWA, Wataru , SAWADA, Naotaka , YAMAMOTO, Fuyuki , LOHANI, Sachin , WANG, Yaling
IPC分类号： C07D487/00 , A61K31/505
CPC分类号： C07D487/04
摘要： The present invention relates to a process for producing a hydrate of 3-(2,6-dichlorophenyl)-4-imino-7-[(2'-methyl-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-7'-yl)amino]-3,4-dihydropyrimido[4,5-d] pyrimidin-2(1H)-one (Compound A) or of a pharmaceutically acceptable salt of Compound A and a crystalline form of Compound A or of a pharmaceutically acceptable salt of Compound A, which are useful in the field of treatment of various cancers as a kinase inhibitor, especially as a Weel kinase inhibitor.
摘要翻译： 本发明涉及制备3-（2,6-二氯苯基）-4-亚氨基-7 - [（2'-甲基-2'，3'-二氢-1'H-螺[环丙烷 -1,4'-异喹啉] -7'-基）氨基] -3,4-二氢嘧啶并[4,5-d]嘧啶-2（1H） - 酮（化合物A）或化合物A的药学上可接受的盐 以及化合物A或化合物A的药学上可接受的盐的结晶形式，其可用于治疗作为激酶抑制剂的各种癌症，特别是作为韦尔激酶抑制剂。
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公开(公告)号：EP2303885B1
公开(公告)日：2013-07-03
申请号：EP09763288.9
申请日：2009-06-02
发明人： FURUKAWA, Shuntaro , IKENO, Taketo , KATO, Shinji , KAWASAKI, Masashi , KOJIMA, Hisaki , MINAGAWA, Wataru , SAWADA, Naotaka , YAMAMOTO, Fuyuki , LOHANI, Sachin , WANG, Yaling
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04
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公开(公告)号：EP1912642B1
公开(公告)日：2012-10-17
申请号：EP06788290.2
申请日：2006-07-24
发明人： FERLITA, Russell, R. , HAGA, Yuji , ISHIKAWA, Makoto , KAMEI, Keisuke , KATO, Shinji , KOJIMA, Hisaki , MOMENT, Aaron , NONOYAMA, Nobuaki , SATAKE, Nobuya , SHIGEMORI, Kazuki , WADA, Toshihiro , WANG, Yaling , WEISSMAN, Steven, A. , WENSLOW, Robert, M.
IPC分类号： A61P3/04 , A61K31/4355 , C07D491/048
CPC分类号： C07D491/10
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公开(公告)号：EP2470189A1
公开(公告)日：2012-07-04
申请号：EP10812600.4
申请日：2010-08-26
发明人： SONG, Zhiguo, Jake , WANG, Yaling , ARTINO, Laura, M. , TELLERS, David, M. , LIEBERMAN, David, R.
IPC分类号： A61K38/00
CPC分类号： C07K5/0808 , C07K5/0812 , C07K5/0827
摘要： The present invention relates to synthetic processes useful in the preparation of macrocyclic compounds of Formula (I) that are useful as inhibitors of the hepatitis C virus NS3 protease and have application in the treatment of conditions caused by the hepatitis C virus. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation.
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公开(公告)号：EP1912642A2
公开(公告)日：2008-04-23
申请号：EP06788290.2
申请日：2006-07-24
发明人： FERLITA, Russell, R. , HAGA, Yuji , ISHIKAWA, Makoto , KAMEI, Keisuke , KATO, Shinji , KOJIMA, Hisaki , MOMENT, Aaron , NONOYAMA, Nobuaki , SATAKE, Nobuya , SHIGEMORI, Kazuki , WADA, Toshihiro , WANG, Yaling , WEISSMAN, Steven, A. , WENSLOW, Robert, M.
IPC分类号： A61K31/4355 , C07D491/048
CPC分类号： C07D491/10
摘要： The present invention relates to a process for producing crystalline trans-N-[l-(2-fluorophenyl)- S-pyrazoly]-3-oxospiro[6-azaisobenzofuran-1(3H),1'-cyclohexane]-4'-carboxamide and novel salts, hydrates and polymorphs thereof.
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