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1.发明授权NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RNA-DEPENDENT RNA VIRAL POLYMERASE 有权核苷AS RNA依赖的RNA病毒聚合酶的抑制剂
公开(公告)号：EP1539188B1
公开(公告)日：2015-01-07
申请号：EP02709095.0
申请日：2002-01-18
发明人： CARROLL, Steven, S. , LAFEMINA, Robert, L. , HALL, Dawn, L. , HIMMELBERGER, Amy, L. , KUO, Lawrence, C. , MACCOSS, Malcolm , OLSEN, David, B. , RUTKOWSKI, Carrie, A. , TOMASSINI, Joanne, E. , AN, Haoyun , BHAT, Balkrishen , BHAT, Neelima , COOK, Phillip, Dan , ELDRUP, Anne, B. , GUINOSSO, Charles, J. , PRHAVC, Marija , PRAKASH, Thazha, P.
IPC分类号： C07H19/14 , A61K31/70 , A61K31/712 , A61K31/7105
CPC分类号： C07H19/16 , A61K9/4858 , A61K31/7056 , A61K31/7064 , A61K31/7076 , A61K38/21 , A61K45/06 , C07D473/00 , C07D487/04 , C07H19/00 , C07H19/06 , C07H19/10 , C07H19/12 , C07H19/14 , C07H19/20 , Y02P20/582 , A61K2300/00
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2.发明公开NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RNA-DEPENDENT RNA VIRAL POLYMERASE 有权核苷AS RNA依赖的RNA病毒聚合酶的抑制剂
公开(公告)号：EP1539188A2
公开(公告)日：2005-06-15
申请号：EP02709095.0
申请日：2002-01-18
发明人： CARROLL, Steven, S. , LAFEMINA, Robert, L. , HALL, Dawn, L. , HIMMELBERGER, Amy, L. , KUO, Lawrence, C. , MACCOSS, Malcolm , OLSEN, David, B. , RUTKOWSKI, Carrie, A. , TOMASSINI, Joanne, E. , AN, Haoyun , BHAT, Balkrishen , BHAT, Neelima , COOK, Phillip, Dan , ELDRUP, Anne, B. , GUINOSSO, Charles, J. , PRHAVC, Marija , PRAKASH, Thazha, P.
IPC分类号： A61K31/70 , A61K31/712 , A61K31/7105
CPC分类号： C07H19/16 , A61K9/4858 , A61K31/7056 , A61K31/7064 , A61K31/7076 , A61K38/21 , A61K45/06 , C07D473/00 , C07D487/04 , C07H19/00 , C07H19/06 , C07H19/10 , C07H19/12 , C07H19/14 , C07H19/20 , Y02P20/582 , A61K2300/00
摘要： The present invention provides nucleoside derivatives which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside derivatives alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside derivatives of the present invention.
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