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公开(公告)号：EP1729772B1
公开(公告)日：2016-12-07
申请号：EP05726105.9
申请日：2005-03-23
发明人： BLACKABY, Wesley , DUGGAN, Mark, E. , HALLETT, David , HARTMAN, George, D. , JENNINGS, Andrew, S. , LEISTER, William, H. , LEWIS, Richard, T. , LINDSLEY, Craig, W. , NAYLOR, Elizabeth , STREET, Leslie, J. , WANG, Yi , WISNOSKI, David, D. , WOLKENBERG, Scott, E. , ZHAO, Zhijian
IPC分类号： C07D409/14 , C07D401/14 , C07D413/14 , C07D401/04
CPC分类号： C07D409/14 , C07D401/04 , C07D401/14 , C07D413/14
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公开(公告)号：EP1729772B8
公开(公告)日：2017-04-19
申请号：EP05726105.9
申请日：2005-03-23
发明人： BLACKABY, Wesley , DUGGAN, Mark, E. , HALLETT, David , HARTMAN, George, D. , JENNINGS, Andrew, S. , LEISTER, William, H. , LEWIS, Richard, T. , LINDSLEY, Craig, W. , NAYLOR, Elizabeth , STREET, Leslie, J. , WANG, Yi , WISNOSKI, David, D. , WOLKENBERG, Scott, E. , ZHAO, Zhijian
IPC分类号： C07D409/14 , C07D401/14 , C07D413/14 , C07D401/04
CPC分类号： C07D409/14 , C07D401/04 , C07D401/14 , C07D413/14
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公开(公告)号：EP1729772A2
公开(公告)日：2006-12-13
申请号：EP05726105.9
申请日：2005-03-23
发明人： BLACKABY, Wesley , DUGGAN, Mark, E. , HALLETT, David , HARTMAN, George, D. , JENNINGS, Andrew, S. , LEISTER, William, H. , LEWIS, Richard, T. , LINDSLEY, Craig, W. , NAYLOR, Elizabeth , STREET, Leslie, J. , WANG, Yi , WISNOSKI, David, D. , WOLKENBERG, Scott, E. , ZHAO, Zhijian
IPC分类号： A61K31/445 , A61K31/505 , A61K31/535 , C07D401/04 , C07D401/14 , C07D413/14
CPC分类号： C07D409/14 , C07D401/04 , C07D401/14 , C07D413/14
摘要： The present invention is directed to pyridyl, pyridazinyl, pyrimidinyl and pyrazinyl piperidine compounds that inhibit the glycine transporter GlyT1 and which are useful in the treatment of neurological and psychiatric disorders associated with glycinergic or glutamatergic neurotransmission dysfunction and diseases in which the glycine transporter GlyT1 is involved.
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