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公开(公告)号：EP1729772B8
公开(公告)日：2017-04-19
申请号：EP05726105.9
申请日：2005-03-23
发明人： BLACKABY, Wesley , DUGGAN, Mark, E. , HALLETT, David , HARTMAN, George, D. , JENNINGS, Andrew, S. , LEISTER, William, H. , LEWIS, Richard, T. , LINDSLEY, Craig, W. , NAYLOR, Elizabeth , STREET, Leslie, J. , WANG, Yi , WISNOSKI, David, D. , WOLKENBERG, Scott, E. , ZHAO, Zhijian
IPC分类号： C07D409/14 , C07D401/14 , C07D413/14 , C07D401/04
CPC分类号： C07D409/14 , C07D401/04 , C07D401/14 , C07D413/14
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公开(公告)号：EP1729772B1
公开(公告)日：2016-12-07
申请号：EP05726105.9
申请日：2005-03-23
发明人： BLACKABY, Wesley , DUGGAN, Mark, E. , HALLETT, David , HARTMAN, George, D. , JENNINGS, Andrew, S. , LEISTER, William, H. , LEWIS, Richard, T. , LINDSLEY, Craig, W. , NAYLOR, Elizabeth , STREET, Leslie, J. , WANG, Yi , WISNOSKI, David, D. , WOLKENBERG, Scott, E. , ZHAO, Zhijian
IPC分类号： C07D409/14 , C07D401/14 , C07D413/14 , C07D401/04
CPC分类号： C07D409/14 , C07D401/04 , C07D401/14 , C07D413/14
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公开(公告)号：EP1558586B1
公开(公告)日：2011-03-30
申请号：EP03779301.5
申请日：2003-10-24
IPC分类号： A61K31/4985 , A61K31/52 , A61K31/519 , A61P35/00 , A61K45/06 , C07D495/04 , C07D241/36 , A61K31/495
CPC分类号： A61K31/495 , A61K45/06 , C07D487/04 , C07D495/04
摘要： The present invention is directed to compounds which contain a five-membered heterocyclic ring fused to a substituted pyrazine moiety which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.
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公开(公告)号：EP1252162B1
公开(公告)日：2012-07-25
申请号：EP01942625.3
申请日：2001-01-16
发明人： DUGGAN, Mark, E. , HALCZENKO, Wasyl , HUTCHINSON, John, H. , LI, Aiwen , MEISSNER, Robert, S. , PERKINS, James, J. , STEELE, Thomas, G. , WANG, Jiabing , PATANE, Michael, A.
IPC分类号： A61K31/444 , A61K31/4166 , A61P19/10 , A61K31/4178 , C07D471/04 , C07D401/14 , C07D405/14 , C07D471/10
CPC分类号： C07D213/73 , A61K45/06 , C07D401/14 , C07D405/14 , C07D471/04 , C07D471/10
摘要： The present invention relates to novel imidazolidinone derivatives thereof, their synthesis, and their use as αν integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors αvβ3 and/or αvβ5 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, inflammatory arthritis, viral disease, cancer, and metastatic tumor growth.
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公开(公告)号：EP1622616B1
公开(公告)日：2011-06-15
申请号：EP04760294.1
申请日：2004-04-20
发明人： BILODEAU, Mark, T. , DUGGAN, Mark, E. , HARTNETT, John, C. , LINDSLEY, Craig, W. , WU, Zhicai , ZHAO, Zhijian
IPC分类号： C07D401/04 , C07D413/04 , C07D413/14 , C07D417/14 , C07D487/04 , A61P35/00 , C07D401/14
CPC分类号： C07F9/65583 , A61K45/06 , C07D401/04 , C07D401/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D487/04
摘要： The present invention is directed to compounds which contain a substituted pyridine moiety which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.
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公开(公告)号：EP1729772A2
公开(公告)日：2006-12-13
申请号：EP05726105.9
申请日：2005-03-23
发明人： BLACKABY, Wesley , DUGGAN, Mark, E. , HALLETT, David , HARTMAN, George, D. , JENNINGS, Andrew, S. , LEISTER, William, H. , LEWIS, Richard, T. , LINDSLEY, Craig, W. , NAYLOR, Elizabeth , STREET, Leslie, J. , WANG, Yi , WISNOSKI, David, D. , WOLKENBERG, Scott, E. , ZHAO, Zhijian
IPC分类号： A61K31/445 , A61K31/505 , A61K31/535 , C07D401/04 , C07D401/14 , C07D413/14
CPC分类号： C07D409/14 , C07D401/04 , C07D401/14 , C07D413/14
摘要： The present invention is directed to pyridyl, pyridazinyl, pyrimidinyl and pyrazinyl piperidine compounds that inhibit the glycine transporter GlyT1 and which are useful in the treatment of neurological and psychiatric disorders associated with glycinergic or glutamatergic neurotransmission dysfunction and diseases in which the glycine transporter GlyT1 is involved.
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