公开(公告)号：EP2863914B1

公开(公告)日：2018-10-03

申请号：EP13807800.1

申请日：2013-06-18

申请人： Merck Sharp & Dohme Corp. ,  Merck Canada Inc.

发明人： MACHACEK, Michele, R. ,  ALTMAN, Michael, D. ,  ROMEO, Eric, T. ,  WITHARANA, Dilrukshi ,  CASH, Brandon ,  SIU, Tony ,  ZHOU, Hua ,  CHRISTOPHER, Matthew ,  KATTAR, Solomon, D. ,  HAIDLE, Andrew, M. ,  CHILDERS, Kaleen Konrad ,  MADDESS, Matthew, H. ,  REUTERSHAN, Michael, H. ,  DUCHARME, Yves ,  GUERIN, David, J. ,  SPENCER, Kerrie ,  BEAULIEU, Christian ,  TRUONG, Vouy Linh ,  GUAY, Daniel ,  NORTHRUP, Alan, B. ,  TAOKA, Brandon, M. ,  LIM, Jongwon ,  FISCHER, Christian ,  BUTCHER, John, W. ,  OTTE, Ryan, D. ,  SUN, Binyuan ,  ELLIS, John, Michael

IPC分类号： A61K31/50 ,  A61K31/501 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D403/14 ,  C07D409/14 ,  C07D471/04 ,  C07D403/12

CPC分类号： C07D471/04 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14

摘要： The present invention provides novel pyrazole derivatives of formula I which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer.

公开(公告)号：EP2863914A1

公开(公告)日：2015-04-29

申请号：EP13807800.1

申请日：2013-06-18

申请人： Merck Sharp & Dohme Corp. ,  Merck Canada Inc.

发明人： MACHACEK, Michele, R. ,  ALTMAN, Michael, D. ,  ROMEO, Eric, T. ,  WITHARANA, Dilrukshi ,  CASH, Brandon ,  SIU, Tony ,  ZHOU, Hua ,  CHRISTOPHER, Matthew ,  KATTAR, Solomon, D. ,  HAIDLE, Andrew, M. ,  CHILDERS, Kaleen Konrad ,  MADDESS, Matthew, H. ,  REUTERSHAN, Michael, H. ,  DUCHARME, Yves ,  GUERIN, David, J. ,  SPENCER, Kerrie ,  BEAULIEU, Christian ,  TRUONG, Vouy Linh ,  GUAY, Daniel ,  NORTHRUP, Alan, B. ,  TAOKA, Brandon, M. ,  LIM, Jongwon ,  FISCHER, Christian ,  BUTCHER, John, W. ,  OTTE, Ryan, D. ,  SUN, Binyuan ,  ELLIS, John, Michael

IPC分类号： A61K31/50 ,  A61K31/501

CPC分类号： C07D471/04 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14

摘要： The present invention provides novel pyrazole derivatives of formula I which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer.

摘要翻译： 本发明提供了式I的新型吡唑衍生物，它们是脾酪氨酸激酶的有效抑制剂，并且可用于治疗和预防由所述酶介导的疾病，例如哮喘，COPD，类风湿性关节炎和癌症。