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公开(公告)号：EP2512246B1
公开(公告)日：2015-09-30
申请号：EP10838241.7
申请日：2010-12-16
发明人： ALTMAN, Michael, D. , ARRINGTON, Kenneth, L. , BURCH, Jason , COTE, Bernard , FOURNIER, Jean-Francois , GAUTHIER, Jacques, Yves , KATTAR, Solomon , KNOWLES, Sandra Lee , LIM, Jongwon , MACHACEK, Michelle, R. , NORTHRUP, Alan, B. , REUTERSHAN, Michael, H. , ROBICHAUD, Joel, S. , SCHELL, Adam, J. , SPENCER, Kerrie, B.
IPC分类号： C07D417/14 , C07D417/12 , C07D471/10 , C07D487/04 , C07D491/10 , A61K31/505 , A61P11/06
CPC分类号： C07D417/12 , C07D417/14 , C07D471/10 , C07D487/04 , C07D491/10
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公开(公告)号：EP2863913B1
公开(公告)日：2018-09-12
申请号：EP13807108.9
申请日：2013-06-18
发明人： LIM, Jongwon , REUTERSHAN, Michael, H. , ELLIS, John Michael , CHILDERS, Kaleen Konrad , DONOFRIO, Anthony , ALTMAN, Michael, D. , HAIDLE, Andrew, M. , ZABIEREK, Anna , CHRISTOPHER, Matthew , GRIMM, Jonathan , BURCH, Jason , FRANCESCO, Maria Emilia Di , PETROCCHI, Alessia , BEAULIEU, Christian , TRUONG, Vouy Linh , NORTHRUP, Alan, B. , BLOUIN, Marc
IPC分类号： A61K31/50 , A61K31/501 , C07D401/14 , C07D403/14 , C07D403/12
CPC分类号： C07D403/12 , C07D401/14 , C07D403/14
摘要： The present invention provides novel imidazole analogs of Formula I which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer.
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公开(公告)号：EP2512246A1
公开(公告)日：2012-10-24
申请号：EP10838241.7
申请日：2010-12-16
发明人： ALTMAN, Michael, D. , ARRINGTON, Kenneth, L. , BURCH, Jason , COTE, Bernard , FOURNIER, Jean-Francois , GAUTHIER, Jacques, Yves , KATTAR, Solomon , KNOWLES, Sandra Lee , LIM, Jongwon , MACHACEK, Michelle, R. , NORTHRUP, Alan, B. , REUTERSHAN, Michael, H. , ROBICHAUD, Joel, S. , SCHELL, Adam, J. , SPENCER, Kerrie, B.
IPC分类号： A01N43/54 , A61K31/505
CPC分类号： C07D417/12 , C07D417/14 , C07D471/10 , C07D487/04 , C07D491/10
摘要： The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis.
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公开(公告)号：EP2863914B1
公开(公告)日：2018-10-03
申请号：EP13807800.1
申请日：2013-06-18
发明人： MACHACEK, Michele, R. , ALTMAN, Michael, D. , ROMEO, Eric, T. , WITHARANA, Dilrukshi , CASH, Brandon , SIU, Tony , ZHOU, Hua , CHRISTOPHER, Matthew , KATTAR, Solomon, D. , HAIDLE, Andrew, M. , CHILDERS, Kaleen Konrad , MADDESS, Matthew, H. , REUTERSHAN, Michael, H. , DUCHARME, Yves , GUERIN, David, J. , SPENCER, Kerrie , BEAULIEU, Christian , TRUONG, Vouy Linh , GUAY, Daniel , NORTHRUP, Alan, B. , TAOKA, Brandon, M. , LIM, Jongwon , FISCHER, Christian , BUTCHER, John, W. , OTTE, Ryan, D. , SUN, Binyuan , ELLIS, John, Michael
IPC分类号： A61K31/50 , A61K31/501 , C07D401/14 , C07D405/14 , C07D413/14 , C07D403/14 , C07D409/14 , C07D471/04 , C07D403/12
CPC分类号： C07D471/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present invention provides novel pyrazole derivatives of formula I which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer.
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公开(公告)号：EP2863916A1
公开(公告)日：2015-04-29
申请号：EP13807050.3
申请日：2013-06-17
发明人： HAIDLE, Andrew, M. , KNOWLES, Sandra Lee , KATTAR, Solomon, D. , DESCHENES, Denis , BURCH, Jason , ROBICHAUD, Joel , CHRISTOPHER, Matthew , ALTMAN, Michael, D. , JEWELL, James, P. , NORTHHRUP, Alan, B. , BLOUIN, Marc , ELLIS, John, Michael , ZHOU, Hua , FISCHER, Christian , SCHELL, Adam, J. , REUTERSHAN, Michael, H. , TAOKA, Brandon, M. , DONOFRIO, Anthony
IPC分类号： A61K31/505 , A61P35/00
CPC分类号： C07D401/12 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K31/551 , A61K45/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D491/08 , C07D491/107 , C07D491/113 , C07D498/04 , A61K2300/00
摘要： The invention provides certain substituted pyridines of the Formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, Rcy, Cy, and t are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk) kinase.
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公开(公告)号：EP2863913A1
公开(公告)日：2015-04-29
申请号：EP13807108.9
申请日：2013-06-18
发明人： LIM, Jongwon , REUTERSHAN, Michael, H. , ELLIS, John Michael , CHILDERS, Kaleen Konrad , DONOFRIO, Anthony , ALTMAN, Michael, D. , HAIDLE, Andrew, M. , ZABIEREK, Anna , CHRISTOPHER, Matthew , GRIMM, Jonathan , BURCH, Jason , FRANCESCO, Maria Emilia Di , PETROCCHI, Alessia , BEAULIEU, Christian , TRUONG, Vouy Linh , NORTHRUP, Alan, B. , BLOUIN, Marc
IPC分类号： A61K31/50 , A61K31/501
CPC分类号： C07D403/12 , C07D401/14 , C07D403/14
摘要： The present invention provides novel imidazole analogs of Formula I which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer.
摘要翻译： 本发明提供了式I的新咪唑类似物，它们是脾酪氨酸激酶的有效抑制剂，并且可用于治疗和预防由所述酶介导的疾病，例如哮喘，COPD，类风湿性关节炎和癌症。
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公开(公告)号：EP2863916B1
公开(公告)日：2018-07-18
申请号：EP13807050.3
申请日：2013-06-17
发明人： HAIDLE, Andrew, M. , KNOWLES, Sandra Lee , KATTAR, Solomon, D. , DESCHENES, Denis , BURCH, Jason , ROBICHAUD, Joel , CHRISTOPHER, Matthew , ALTMAN, Michael, D. , JEWELL, James, P. , NORTHHRUP, Alan, B. , BLOUIN, Marc , ELLIS, John, Michael , ZHOU, Hua , FISCHER, Christian , SCHELL, Adam, J. , REUTERSHAN, Michael, H. , TAOKA, Brandon, M. , DONOFRIO, Anthony
IPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D491/08 , C07D491/107 , C07D491/113 , C07D498/04 , A61K31/506 , A61P11/06 , A61P19/02 , A61P29/00 , A61P35/00 , A61P37/00
CPC分类号： C07D401/12 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K31/551 , A61K45/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D491/08 , C07D491/107 , C07D491/113 , C07D498/04 , A61K2300/00
摘要： The invention provides certain substituted pyridines of the Formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, Rcy, Cy, and t are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk) kinase.
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公开(公告)号：EP2863914A1
公开(公告)日：2015-04-29
申请号：EP13807800.1
申请日：2013-06-18
发明人： MACHACEK, Michele, R. , ALTMAN, Michael, D. , ROMEO, Eric, T. , WITHARANA, Dilrukshi , CASH, Brandon , SIU, Tony , ZHOU, Hua , CHRISTOPHER, Matthew , KATTAR, Solomon, D. , HAIDLE, Andrew, M. , CHILDERS, Kaleen Konrad , MADDESS, Matthew, H. , REUTERSHAN, Michael, H. , DUCHARME, Yves , GUERIN, David, J. , SPENCER, Kerrie , BEAULIEU, Christian , TRUONG, Vouy Linh , GUAY, Daniel , NORTHRUP, Alan, B. , TAOKA, Brandon, M. , LIM, Jongwon , FISCHER, Christian , BUTCHER, John, W. , OTTE, Ryan, D. , SUN, Binyuan , ELLIS, John, Michael
IPC分类号： A61K31/50 , A61K31/501
CPC分类号： C07D471/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present invention provides novel pyrazole derivatives of formula I which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer.
摘要翻译： 本发明提供了式I的新型吡唑衍生物，它们是脾酪氨酸激酶的有效抑制剂，并且可用于治疗和预防由所述酶介导的疾病，例如哮喘，COPD，类风湿性关节炎和癌症。
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公开(公告)号：EP3833355A1
公开(公告)日：2021-06-16
申请号：EP19846885.2
申请日：2019-08-05
发明人： MACHACEK, Michelle , WITTER, David , GIBEAU, Craig , HUANG, Chunhui , KAWAMURA, Shuhei , SLOMAN, David, L. , SILIPHAIVANH, Phieng , QUIROZ, Ryan , WAN, Murray , SCHNEIDER, Sebastian , YEUNG, Charles, S. , REUTERSHAN, Michael, H. , HENDERSON, Timothy, J. , PAPARIN, Jean-Laurent , RAHALI, Houcine , HUGHES, Jonathan, M., E. , SANYAL, Sulagna , YE, Yingchun , CANDITO, David, A. , FIER, Patrick, S. , SILVERMAN, Steven, M.
IPC分类号： A61K31/519 , C07D471/04
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公开(公告)号：EP3833668A1
公开(公告)日：2021-06-16
申请号：EP19847252.4
申请日：2019-08-05
发明人： WITTER, David , KAWAMURA, Shuhei , MACHACEK, Michelle , QUIROZ, Ryan , REUTERSHAN, Michael, H. , SCHNEIDER, Sebastian , SILIPHAIVANH, Phieng , YE, Yingchun , YEUNG, Charles, S.
IPC分类号： C07D487/04 , C07D519/00
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