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公开(公告)号：EP2863914A1
公开(公告)日：2015-04-29
申请号：EP13807800.1
申请日：2013-06-18
发明人： MACHACEK, Michele, R. , ALTMAN, Michael, D. , ROMEO, Eric, T. , WITHARANA, Dilrukshi , CASH, Brandon , SIU, Tony , ZHOU, Hua , CHRISTOPHER, Matthew , KATTAR, Solomon, D. , HAIDLE, Andrew, M. , CHILDERS, Kaleen Konrad , MADDESS, Matthew, H. , REUTERSHAN, Michael, H. , DUCHARME, Yves , GUERIN, David, J. , SPENCER, Kerrie , BEAULIEU, Christian , TRUONG, Vouy Linh , GUAY, Daniel , NORTHRUP, Alan, B. , TAOKA, Brandon, M. , LIM, Jongwon , FISCHER, Christian , BUTCHER, John, W. , OTTE, Ryan, D. , SUN, Binyuan , ELLIS, John, Michael
IPC分类号： A61K31/50 , A61K31/501
CPC分类号： C07D471/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present invention provides novel pyrazole derivatives of formula I which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer.
摘要翻译： 本发明提供了式I的新型吡唑衍生物，它们是脾酪氨酸激酶的有效抑制剂，并且可用于治疗和预防由所述酶介导的疾病，例如哮喘，COPD，类风湿性关节炎和癌症。
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公开(公告)号：EP2863914B1
公开(公告)日：2018-10-03
申请号：EP13807800.1
申请日：2013-06-18
发明人： MACHACEK, Michele, R. , ALTMAN, Michael, D. , ROMEO, Eric, T. , WITHARANA, Dilrukshi , CASH, Brandon , SIU, Tony , ZHOU, Hua , CHRISTOPHER, Matthew , KATTAR, Solomon, D. , HAIDLE, Andrew, M. , CHILDERS, Kaleen Konrad , MADDESS, Matthew, H. , REUTERSHAN, Michael, H. , DUCHARME, Yves , GUERIN, David, J. , SPENCER, Kerrie , BEAULIEU, Christian , TRUONG, Vouy Linh , GUAY, Daniel , NORTHRUP, Alan, B. , TAOKA, Brandon, M. , LIM, Jongwon , FISCHER, Christian , BUTCHER, John, W. , OTTE, Ryan, D. , SUN, Binyuan , ELLIS, John, Michael
IPC分类号： A61K31/50 , A61K31/501 , C07D401/14 , C07D405/14 , C07D413/14 , C07D403/14 , C07D409/14 , C07D471/04 , C07D403/12
CPC分类号： C07D471/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present invention provides novel pyrazole derivatives of formula I which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer.
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3.发明授权
公开(公告)号：EP1379520B2
公开(公告)日：2014-04-09
申请号：EP02721105.1
申请日：2002-02-20
发明人： CLAIBORNE, Christopher, F. , BUTCHER, John, W. , CLAREMON, David, A. , LIBBY, Brian, E. , LIVERTON, Nigel, J. , MUNSON, Peter, M. , NGUYEN, Kevin, T. , PHILLIPS, Brian , THOMPSON, Wayne , MCCAULEY, John, A.
IPC分类号： C07D401/12 , C07D471/08 , C07D487/04 , A61K31/444 , A61P29/02
CPC分类号： C07D409/14 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12 , C07D451/02 , C07D471/04 , C07D473/16 , C07D473/34 , C07D475/08
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公开(公告)号：EP2720545B1
公开(公告)日：2016-11-30
申请号：EP12799914.2
申请日：2012-06-14
发明人： PALANI, Anandan , HUANG, Xianhai , BRUBAKER, Jason , PETERSON, Scott, L. , BUTCHER, John, W. , CLOSE, Joshua, T. , MARTINEZ, Michelle , MACCOSS, Rachel, Nicola , JUNG, Joon, O. , SILIPHAIVANH, Phieng , ZHANG, Hongjun , ASLANIAN, Robert, G. , BIJU, Purakkattle, Johny , DONG, Li , HUANG, Ying , MCCORMICK, Kevin, D. , SHAO, Ning , ZHOU, Wei
IPC分类号： A01N43/42 , C07D215/00 , C07D221/16 , A61K31/473 , A61K31/501 , A61K31/506 , A61K31/5377 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/12 , C07D417/12 , C07D405/06 , C07D417/10
CPC分类号： C07D221/16 , A61K31/473 , A61K31/501 , A61K31/506 , A61K31/5377 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/12 , C07D417/10 , C07D417/12
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公开(公告)号：EP2720545A1
公开(公告)日：2014-04-23
申请号：EP12799914.2
申请日：2012-06-14
发明人： PALANI, Anandan , HUANG, Xianhai , BRUBAKER, Jason , PETERSON, Scott, L. , BUTCHER, John, W. , CLOSE, Joshua, T. , MARTINEZ, Michelle , MACCOSS, Rachel, Nicola , JUNG, Joon, O. , SILIPHAIVANH, Phieng , ZHANG, Hongjun , ASLANIAN, Robert, G. , BIJU, Purakkattle, Johny , DONG, Li , HUANG, Ying , MCCORMICK, Kevin, D. , SHAO, Ning , ZHOU, Wei
IPC分类号： A01N43/42 , C07D215/00
CPC分类号： C07D221/16 , A61K31/473 , A61K31/501 , A61K31/506 , A61K31/5377 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/12 , C07D417/10 , C07D417/12
摘要： The invention provides certain cycloalkyl-fused tetrahydroquinolines of the Formula (I), and their pharmaceutically acceptable salts and esters, wherein R
1 , R
2 , R
7 , R
8 , R
8a , E, Y, Z, n, u, and t are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions associated with with uncontrolled or inappropriate stimulation of CRTH
2 function.-
6.发明授权2-PYRIDYL CARBOXAMIDE-CONTAINING SPLEEN TYROSINE KINASE (SYK) INHIBITORS 有权2-吡啶基甲酰胺CONTAINING MILZTYROSINKINASE抑制剂
公开(公告)号：EP2763976B1
公开(公告)日：2016-05-18
申请号：EP12838717.2
申请日：2012-10-01
发明人： ALTMAN, Michael, D. , BIENSTOCK, Core, E. , BUTCHER, John, W. , DI FRANCESCO, Maria Emilia , DONOFRIO, Anthony , ELLIS, John Michael , FISCHER, Christian , HAIDLE, Andrew, M. , HAIDLE, Andrew, M. , JEWELL, James, P. , KNOWLES, Sandra Lee , NORTHRUP, Alan, B. , OTTE, Ryan, D. , PETERSON, Scott, L. , SMITH, Graham frank
IPC分类号： C07D401/12 , A61P37/00 , C07D405/14 , C07D413/14 , A61K31/444 , C07D409/14 , C07D417/14 , C07D487/04 , C07D495/04
CPC分类号： A61K31/4439 , A61K31/444 , A61K31/496 , A61K31/5025 , A61K31/506 , A61K31/519 , A61K31/5377 , C07D213/81 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D495/04
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7.发明公开2-PYRIDYL CARBOXAMIDE-CONTAINING SPLEEN TYROSINE KINASE (SYK) INHIBITORS 有权2-吡啶基甲酰胺CONTAINING MILZTYROSINKINASE抑制剂
公开(公告)号：EP2763976A1
公开(公告)日：2014-08-13
申请号：EP12838717.2
申请日：2012-10-01
发明人： ALTMAN, Michael, D. , BIENSTOCK, Core, E. , BUTCHER, John, W. , DI FRANCESCO, Maria Emilia , DONOFRIO, Anthony , ELLIS, John Michael , FISCHER, Christian , HAIDLE, Andrew, M. , HAIDLE, Andrew, M. , JEWELL, James, P. , KNOWLES, Sandra Lee , NORTHRUP, Alan, B. , OTTE, Ryan, D. , PETERSON, Scott, L. , SMITH, Graham frank
IPC分类号： C07D401/00
CPC分类号： A61K31/4439 , A61K31/444 , A61K31/496 , A61K31/5025 , A61K31/506 , A61K31/519 , A61K31/5377 , C07D213/81 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D495/04
摘要： The invention provides certain 2-pyridyl carboxamide-containing compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein A and B are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk) kinase.
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公开(公告)号：EP2271345A1
公开(公告)日：2011-01-12
申请号：EP09739426.6
申请日：2009-04-16
发明人： LIVERTON, Nigel, J. , MCCAULEY, John, A. , BUTCHER, John, W. , GILBERT, Kevin, F. , MCINTYRE, Charles, J. , RUDD, Michael, T.
IPC分类号： A61K31/505
CPC分类号： C07K5/123 , A61K38/00 , C07D498/18 , C07K5/08 , C07K5/0804 , C07K5/0812
摘要： The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.
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公开(公告)号：EP2763535B1
公开(公告)日：2017-06-07
申请号：EP12838515.0
申请日：2012-09-28
发明人： BUTCHER, John, W. , WITTER, David , DINSMORE, Christopher , KIM, June , HENDRIX, John , ARCHARYA, Raksha , AHEARN, Sean, P. , JUNG, Joon , RIVKIN, Alexey , JONES, Philip
IPC分类号： C07D519/00 , C07D471/04
CPC分类号： C07D471/04 , C07D519/00
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公开(公告)号：EP2271345B1
公开(公告)日：2015-05-20
申请号：EP09739426.6
申请日：2009-04-16
发明人： LIVERTON, Nigel, J. , MCCAULEY, John, A. , BUTCHER, John, W. , GILBERT, Kevin, F. , MCINTYRE, Charles, J. , RUDD, Michael, T.
IPC分类号： C07D498/18 , A61K31/505 , A61P31/18
CPC分类号： C07K5/123 , A61K38/00 , C07D498/18 , C07K5/08 , C07K5/0804 , C07K5/0812
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