公开(公告)号：EP4281077A1

公开(公告)日：2023-11-29

申请号：EP22743211.9

申请日：2022-01-21

申请人： Microbiotix, Inc. ,  The United States of America, as Represented by the Secretary, Department of Health and Human Services

发明人： WAIDYARACHCHI, Samanthi, L. ,  NGUYEN, Son, T. ,  DING, Xiaoyuan ,  ADHIKARI, Sharmila ,  WILLIAMS, John, D. ,  PEET, Norton, P. ,  ARON, Zachary, D. ,  DESAI, Sanjay, A. ,  BUTLER, Michelle, M.

IPC分类号： A61K31/50 ,  A61K31/501 ,  A61P33/00 ,  C07D207/18 ,  C07D277/20 ,  C07D277/22

公开(公告)号：EP2991648A2

公开(公告)日：2016-03-09

申请号：EP14792100.1

申请日：2014-05-03

申请人： Microbiotix, Inc.

发明人： OPPERMAN, Timothy, J. ,  NGUYEN, Son, T. ,  KWASNY, Steven, M. ,  DING, Xiaoyuan

IPC分类号： A61K31/436

CPC分类号： C07D491/052 ,  A01N43/90 ,  A01N47/44 ,  A61K31/436 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/5383 ,  A61K31/541 ,  A61K31/551 ,  A61K31/553 ,  A61K45/06 ,  C07D493/04 ,  C07D513/04 ,  Y02A50/473 ,  Y02A50/478 ,  Y02A50/481 ,  Y02A50/483 ,  A61K2300/00

摘要： The compounds are potent bacterial efflux pump inhibitors (EPIs). Such compounds are useful to potentiate the antimicrobial activity of antimicrobial compounds such as beta-lactam antibiotics and quinolone antibiotics against Gram-negative bacteria.