公开(公告)号：EP4281077A1

公开(公告)日：2023-11-29

申请号：EP22743211.9

申请日：2022-01-21

申请人： Microbiotix, Inc. ,  The United States of America, as Represented by the Secretary, Department of Health and Human Services

发明人： WAIDYARACHCHI, Samanthi, L. ,  NGUYEN, Son, T. ,  DING, Xiaoyuan ,  ADHIKARI, Sharmila ,  WILLIAMS, John, D. ,  PEET, Norton, P. ,  ARON, Zachary, D. ,  DESAI, Sanjay, A. ,  BUTLER, Michelle, M.

IPC分类号： A61K31/50 ,  A61K31/501 ,  A61P33/00 ,  C07D207/18 ,  C07D277/20 ,  C07D277/22

公开(公告)号：EP2313100A1

公开(公告)日：2011-04-27

申请号：EP09790437.9

申请日：2009-07-15

申请人： The United States Of America, As Represented By The Secretary, Department Of Health And Human Services

发明人： DESAI, Sanjay, A. ,  PILLAI, Ajay, D.

IPC分类号： A61K31/554 ,  A61K31/165 ,  A61K31/421 ,  A61K31/4245 ,  A61K31/433 ,  A61K31/4355 ,  A61K31/437 ,  A61P33/06

CPC分类号： A61K31/553 ,  A61K31/165 ,  A61K31/4155 ,  A61K31/421 ,  A61K31/423 ,  A61K31/4245 ,  A61K31/433 ,  A61K31/4355 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/4741 ,  A61K31/4745 ,  A61K31/50 ,  A61K31/554 ,  A61K45/06 ,  C07D263/57 ,  C07D281/16 ,  C07D403/08 ,  C07D413/14 ,  C07D417/06 ,  C07D491/048 ,  C07D498/04 ,  C07D513/04 ,  Y02A50/411 ,  A61K2300/00

摘要： Disclosed are inhibitors of the plasmodial surface anion channel (PSAC) inhibitors and the use thereof in treating or preventing malaria in an animal such as a human, comprising administering an effective amount of an inhibitor or a combination of inhibitors. An example of such an inhibitor is a compound of formula I, Formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 to R7 are as described herein.

公开(公告)号：EP2313100B1

公开(公告)日：2016-05-11

申请号：EP09790437.9

申请日：2009-07-15

申请人： The United States Of America, As Represented By The Secretary, Department Of Health And Human Services

发明人： DESAI, Sanjay, A. ,  PILLAI, Ajay, D.

IPC分类号： A61K31/554 ,  A61K31/165 ,  A61K31/4245 ,  A61K31/433 ,  A61K31/4355 ,  A61K31/437 ,  A61P33/06 ,  A61K31/4155 ,  A61K31/423 ,  A61K31/4439 ,  A61K31/4745 ,  A61K31/50 ,  A61K31/4741 ,  C07D413/14 ,  C07D403/08 ,  C07D417/06 ,  C07D263/57 ,  C07D491/048 ,  C07D498/04 ,  C07D281/16 ,  C07D513/04

CPC分类号： A61K31/553 ,  A61K31/165 ,  A61K31/4155 ,  A61K31/421 ,  A61K31/423 ,  A61K31/4245 ,  A61K31/433 ,  A61K31/4355 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/4741 ,  A61K31/4745 ,  A61K31/50 ,  A61K31/554 ,  A61K45/06 ,  C07D263/57 ,  C07D281/16 ,  C07D403/08 ,  C07D413/14 ,  C07D417/06 ,  C07D491/048 ,  C07D498/04 ,  C07D513/04 ,  Y02A50/411 ,  A61K2300/00

摘要： Disclosed are inhibitors of the plasmodial surface anion channel (PSAC) inhibitors and the use thereof in treating or preventing malaria in an animal such as a human, comprising administering an effective amount of an inhibitor or a combination of inhibitors. An example of such an inhibitor is a compound of formula I, Formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 to R7 are as described herein.