利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

12 条记录 (耗时 0.016 秒)

    NANOPARTICLE TUMOUR VACCINES
    1.
    发明公开
    NANOPARTICLE TUMOUR VACCINES 审中-公开
    纳米粒子肿瘤疫苗

    公开(公告)号：EP2753361A1

    公开(公告)日：2014-07-16

    申请号：EP12768753.1

    申请日：2012-09-07

    申请人： Midatech Ltd. ,  Immunotope, Inc.

    发明人： RADEMACHER, Thomas ,  PHILIP, Ramila

    IPC分类号： A61K47/48 ,  A61P35/00

    CPC分类号： A61K9/141 ,  A61K39/0011 ,  A61K47/6923 ,  A61K47/6929

    摘要： The present invention provides a vaccine for the prophylactic or therapeutic treatment of a tumour in a mammalian subject, as well as methods of using the vaccine, including in treatment of tumours and in generating a CTL response. The vaccine comprises a plurality of nanoparticles and a pharmaceutically acceptable carrier, salt or diluent. The nanoparticles comprise a core comprising a metal and/or a semiconductor atom; and a corona comprising a plurality of ligands covalently linked to the core, wherein at least a first ligand of said plurality comprises a carbohydrate moiety that iscovalently linked to the core via a first linker, and wherein at least a second ligand of said plurality comprises an epitopic peptide that is covalently linked to the core via a second linker, said second linker comprising a peptide portion and a non-peptide portion, wherein said peptide portion comprises the sequence X
    1 X
    2 Z
    1 , wherein: X
    1 is an amino acid selected from A and G; X
    2 is an amino acid selected from A and G; and Z
    1 is an amino acid selected from Y and F, and wherein said epitopic peptide forms at least a portion of or is derived from a Tumour-Associated Antigen (TAA).

    NANOPARTICLE DELIVERY COMPOSITIONS
    7.
    发明公开
    NANOPARTICLE DELIVERY COMPOSITIONS 有权
    纳米颗粒递送组合物

    公开(公告)号：EP2956119A1

    公开(公告)日：2015-12-23

    申请号：EP14708315.8

    申请日：2014-02-07

    申请人： Midatech Ltd.

    发明人： MALE, David K. ,  RADEMACHER, Thomas

    IPC分类号： A61K9/00 ,  A61K47/48 ,  A61K49/18 ,  A61K9/51 ,  B82Y5/00 ,  A61P25/00

    CPC分类号： A61K9/5123 ,  A61K9/0009 ,  A61K9/5115 ,  A61K9/5192 ,  A61K38/1709 ,  A61K39/3955 ,  A61K49/1824 ,  B82Y5/00 ,  Y10S977/773 ,  Y10S977/788 ,  Y10S977/81 ,  Y10S977/906 ,  Y10S977/93

    摘要： Nanoparticle delivery systems for use in targeting biologically active agents to the central nervous system comprise a composition comprising (a) a nanoparticle comprising: (i) a core comprising a metal and/or a semiconductor; and (ii) a corona comprising a plurality of ligands covalently linked to the core, wherein said ligands comprise a carbohydrate, insulin and/or a glutathione; and (b) the at least one agent to be delivered to the CNS. Methods of treatment and diagnosing CNS disorders utilizing the nanoparticle delivery systems and related screening methods are also disclosed.

    摘要翻译： 用于将生物活性剂靶向中枢神经系统的纳米粒子递送系统包含组合物，其包含（a）纳米粒子，所述纳米粒子包含：（i）包含金属和/或半导体的核; 和（ii）包含共价连接至所述核心的多个配体的冠，其中所述配体包含碳水化合物，胰岛素和/或谷胱甘肽; 和（b）至少一个代理将被传送到CNS。 还公开了使用纳米粒子递送系统和相关筛选方法治疗和诊断CNS障碍的方法。

    NANOPARTICLE PEPTIDE COMPOSITIONS
    10.
    发明公开
    NANOPARTICLE PEPTIDE COMPOSITIONS 审中-公开
    纳米颗粒肽组合物

    公开(公告)号：EP2964263A1

    公开(公告)日：2016-01-13

    申请号：EP14705556.0

    申请日：2014-02-06

    申请人： Midatech Ltd.

    发明人： WILLIAMS, Phillip ,  RADEMACHER, Thomas

    IPC分类号： A61K47/48 ,  A61P19/08

    CPC分类号： A61K9/146 ,  A61K38/29 ,  A61K47/6923 ,  A61K47/6929

    摘要： The present invention relates to teriparatide peptide-carrying nanoparticles, particularly for use in medicine, and includes methods for treatment of disorders, e.g., of bone density. Nanoparticle composition comprise a nanoparticle comprising a core comprising a metal and/or a semiconductor; and a corona comprising a plurality of ligands covalently linked to the core, wherein said plurality of ligands comprise at least one glutathione; and at least one teriparatide peptide that is non-covalently bound to the corona.

    摘要翻译： 本发明涉及携带特立帕肽的纳米颗粒，特别用于医学，并且包括用于治疗例如骨密度病症的方法。 纳米颗粒组合物包含纳米颗粒，所述纳米颗粒包含含有金属和/或半导体的核心; 以及包含共价连接至所述核的多个配体的冠，其中所述多个配体包含至少一个谷胱甘肽; 和至少一种非共价结合于冠的特立帕肽。