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    NANOPARTICLE TUMOUR VACCINES
    1.
    发明公开
    NANOPARTICLE TUMOUR VACCINES 审中-公开
    纳米粒子肿瘤疫苗

    公开(公告)号：EP2753361A1

    公开(公告)日：2014-07-16

    申请号：EP12768753.1

    申请日：2012-09-07

    申请人： Midatech Ltd. ,  Immunotope, Inc.

    发明人： RADEMACHER, Thomas ,  PHILIP, Ramila

    IPC分类号： A61K47/48 ,  A61P35/00

    CPC分类号： A61K9/141 ,  A61K39/0011 ,  A61K47/6923 ,  A61K47/6929

    摘要： The present invention provides a vaccine for the prophylactic or therapeutic treatment of a tumour in a mammalian subject, as well as methods of using the vaccine, including in treatment of tumours and in generating a CTL response. The vaccine comprises a plurality of nanoparticles and a pharmaceutically acceptable carrier, salt or diluent. The nanoparticles comprise a core comprising a metal and/or a semiconductor atom; and a corona comprising a plurality of ligands covalently linked to the core, wherein at least a first ligand of said plurality comprises a carbohydrate moiety that iscovalently linked to the core via a first linker, and wherein at least a second ligand of said plurality comprises an epitopic peptide that is covalently linked to the core via a second linker, said second linker comprising a peptide portion and a non-peptide portion, wherein said peptide portion comprises the sequence X
    1 X
    2 Z
    1 , wherein: X
    1 is an amino acid selected from A and G; X
    2 is an amino acid selected from A and G; and Z
    1 is an amino acid selected from Y and F, and wherein said epitopic peptide forms at least a portion of or is derived from a Tumour-Associated Antigen (TAA).