公开(公告)号：EP1235807A1

公开(公告)日：2002-09-04

申请号：EP00980439.4

申请日：2000-11-17

申请人： Millennium Pharmaceuticals, Inc.

发明人： ZHU, Bing-Yan ,  WANG, Lingyan ,  HUANG, Wenrong ,  WU, Yanhong ,  ZUCKETT, Jingmei, Fan ,  SU, Ting ,  SCARBOROUGH, Robert

IPC分类号： C07D213/75 ,  C07D295/18 ,  C07C311/16 ,  C07C311/18 ,  C07D409/12 ,  A61K31/44 ,  A61K31/18 ,  A61P7/02

CPC分类号： C07D213/81 ,  C07C311/16 ,  C07C311/19 ,  C07C311/46 ,  C07D295/185

摘要： Novel β-amino acid-, aspartic acid- and diaminopropionic-based compounds of the general formula A-Q-D-E-G-J-X wherein A, Q, D, E, G, J and X have the meanings given in the description, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.

公开(公告)号：EP1322637A2

公开(公告)日：2003-07-02

申请号：EP01979305.8

申请日：2001-10-01

申请人： Millennium Pharmaceuticals, Inc.

发明人： ZHU, Bing-Yan ,  HUANG, Wenrong ,  ZHANG, Penglie ,  JIA, Zhaozhong, Jon ,  BAO, Liang ,  WU, Yanhong ,  SCARBOROUGH, Robert, M.

IPC分类号： C07D401/14 ,  C07D401/12 ,  C07D213/75 ,  A61K31/44 ,  A61K31/4427 ,  A61P7/02

CPC分类号： C07D213/75 ,  C07D401/12 ,  C07D401/14

摘要： Novel quaternary amidino-containing compounds of the general formulae (I), (II), (III), (IV), (V) and (VI): including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and the compositions are useful in vitro or in vivo for preventing or treating conditions in mammals characterized by undesired thrombosis.

公开(公告)号：EP1322610A2

公开(公告)日：2003-07-02

申请号：EP01975505.7

申请日：2001-10-01

申请人： Millennium Pharmaceuticals, Inc.

发明人： ZHU, Bing-Yan ,  JIA, Zhaozhong, Jon ,  ZHANG, Penglie ,  HUANG, Wenrong ,  WU, Yanhong ,  ZUCKETT, Jingmei, Fan ,  GOLDMAN, Erik, A. ,  WANG, Lingyan ,  SONG, Yonghong ,  SCARBOROUGH, Robert, M.

IPC分类号： C07D209/30

CPC分类号： C07D239/06 ,  C07D205/04 ,  C07D209/30 ,  C07D233/06 ,  C07D295/26 ,  C07D333/62 ,  C07D401/12 ,  C07D403/12 ,  C07D409/12 ,  C07D409/14

摘要： Novel compounds of the general formulae (I) or (II), including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and the compositions are useful in vitro or in vivo for preventing or treating conditions in mammals characterized by undesired thrombosis.