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公开(公告)号：EP4240489A1
公开(公告)日：2023-09-13
申请号：EP21889899.7
申请日：2021-11-02
发明人： MARX, Matthew Arnold , LAWSON, John David , DOERNER BARBAUR, Patrick Michael , BLAKE, James Francis , FELL, Jay Bradford , FISCHER, John, Peter , NEWHOUSE, Bradley J. , NGUYEN, Phong , O'LEARY, Jacob M. , PAJK, Spencer , RODRIGUEZ, Martha E. , TANG, Tony Pisal
IPC分类号： A61P35/00 , C07D417/14 , A61K31/517
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公开(公告)号：EP4216951A1
公开(公告)日：2023-08-02
申请号：EP21873279.0
申请日：2021-09-21
发明人： WANG, Xiaolun , MARX, Matthew Arnold , ALLEN, Shelley , CHICARELLI, Mark Joseph , DAHLKE, Joshua Ryan , DAI, Donghua , FELL, Jay Bradford , FISCHER John, Peter , HILTON, Michael Christopher , KAHN, Dean Russell , MEJIA, Macedonio Junior , NGUYEN, Phong , PAJK, Spencer , RODRIGUEZ, Martha E. , SAVECHENKOV, Pavel Yu , TANG, Tony Pisal
IPC分类号： A61K31/4353 , A61K31/519 , C07D471/04
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公开(公告)号：EP4021444A1
公开(公告)日：2022-07-06
申请号：EP20859068.7
申请日：2020-08-27
发明人： WANG, Xiaolun , BURNS, Aaron Craig , CHRISTENSEN, James Gail , KETCHAM, John Michael , LAWSON, John David , MARX, Matthew Arnold , SMITH, Christopher Ronald , ALLEN, Shelley , BLAKE, James Francis , CHICARELLI, Mark Joseph , DAHLKE, Joshua Ryan , DAI, Donghua , FELL, Jay Bradford , FISCHER, John Peter , MEJIA, Macedonio J. , NEWHOUSE, Brad , NGUYEN, Phong , O'LEARY, Jacob Matthew , PAJK, Spencer , RODRIGUEZ, Martha E. , SAVECHENKOV, Pavel , TANG, Tony P. , VIGERS, Guy P. A. , ZHAO, Qian , KAHN, Dean Russell , GAUDINO, John , HILTON, Michael Christopher
IPC分类号： A61K31/435 , A61K31/4375 , A61K31/517 , C07D471/00 , C07D471/02 , C07D471/04
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4.发明授权SUBSTITUTED N-(1H-INDAZOL-4-YL)IMIDAZO[1,2-a]PYRIDINE-3-CARBOXAMIDE COMPOUNDS AS TYPE III RECEPTOR TYROSINE KINASE INHIBITORS 有权取代的N-（1H-吲唑-4-基）咪唑并[1,2-a]吡啶-3-甲酰胺，为III型受体TYROSINKINASENHIBITOREN
公开(公告)号：EP2651939B1
公开(公告)日：2015-04-08
申请号：EP11808427.6
申请日：2011-12-13
发明人： BOYS, Mark Laurence , DELISLE, Robert Kirk , HICKEN, Erik James , KENNEDY, April L. , MARESKA, David A. , MARMSATER, Fredrik P. , MUNSON, Mark C. , NEWHOUSE, Brad , RAST, Bryson , RIZZI, James P. , RODRIGUEZ, Martha E. , TOPALOV, George T. , ZHAO, Qian
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04 , A61K31/496 , A61K45/06
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5.发明公开SUBSTITUTED N-(1H-INDAZOL-4-YL)IMIDAZO[1,2-a]PYRIDINE-3-CARBOXAMIDE COMPOUNDS AS TYPE III RECEPTOR TYROSINE KINASE INHIBITORS 有权取代的N-（1H-吲唑-4-基）咪唑并[1,2-a]吡啶-3-甲酰胺，为III型受体TYROSINKINASENHIBITOREN
公开(公告)号：EP2651939A1
公开(公告)日：2013-10-23
申请号：EP11808427.6
申请日：2011-12-13
发明人： BOYS, Mark Laurence , DELISLE, Robert Kirk , HICKEN, Erik James , KENNEDY, April L. , MARESKA, David A. , MARMSATER, Fredrik P. , MUNSON, Mark C. , NEWHOUSE, Brad , RAST, Bryson , RIZZI, James P. , RODRIGUEZ, Martha E. , TOPALOV, George T. , ZHAO, Qian
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04 , A61K31/496 , A61K45/06
摘要： Compounds of Formula I: and pharmaceutically acceptable salts thereof in which R
1 , R
2 , R
3 , R
4 , R
5 and R
6 have the meanings given in the specification, are inhibitors of cFMS and are useful in the treatment of fibrosis, bone-related diseases, cancer, autoimmune disorders, inflammatory diseases, cardiovascular diseases, pain and burns in a mammal.-
公开(公告)号：EP3867238A1
公开(公告)日：2021-08-25
申请号：EP19801996.0
申请日：2019-10-17
申请人： Array BioPharma Inc.
发明人： BLAKE, James F. , BOYS, Mark Laurence , CHICARELLI, Mark Joseph , COOK, Adam , ELSAYED, Mohamed S. A. , FELL, Jay B. , FISCHER, John P. , HINKLIN, Ronald Jay , MCNULTY, Oren T. , MEJIA, Macedonio J. , RODRIGUEZ, Martha E. , WONG, Christina E.
IPC分类号： C07D401/04 , C07D471/04 , C07D519/00 , A61P35/00 , A61K31/498 , A61K31/4985
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7.发明公开SUBSTITUTED N-(1H-INDAZOL-4-YL)IMIDAZO[1, 2-A]PYRIDINE-3- CARBOXAMIDE COMPOUNDS AS CFMS INHIBITORS 有权取代的N-（1H-吲唑-4-基）咪唑并+ AFS-1，2-A + AF0 - 吡啶-3-甲酰胺作为抑制剂CFMS
公开(公告)号：EP2516433A1
公开(公告)日：2012-10-31
申请号：EP10798683.8
申请日：2010-12-20
发明人： BOYS, Mark Laurence , BRADLEY, Michael F. , DELISLE, Robert Kirk , HENNINGS, D. David , KENNEDY, April L. , MARMSATER, Fredrik P. , MEDINA, Matthew David , MUNSON, Mark C. , RAST, Bryson , RIZZI, James P. , RODRIGUEZ, Martha E. , TOPALOV, George T. , ZHAO, Qian
IPC分类号： C07D471/04 , C07D519/00 , A61K31/437 , A61K31/4985 , A61P9/00 , A61P19/08 , A61P29/00 , A61P35/00
CPC分类号： C07D471/04 , C07D519/00
摘要： Compounds of Formula (I): and pharmaceutically acceptable salts thereof in which R
1 , R
2 , R
3 , R
4 and R
5 have the meanings given in the specification, are inhibitors of cFMS and are useful in the treatment of bone-related diseases, cancer, autoimmune disorders, inflammatory diseases, cardiovascular diseases and pain.-
公开(公告)号：EP3947367A1
公开(公告)日：2022-02-09
申请号：EP20718387.2
申请日：2020-03-30
发明人： BLAKE, James F. , BOYS, Mark Laurence , CHICARELLI, Mark Joseph , COOK, Adam W. , ELSAYED, Mohamed S. A. , FELL, Jay Bradford , FISCHER, John P. , HINKLIN, Ronald Jay , JIANG, Yutong , MCNULTY, Oren T. , MEJIA, Macedonio J. , RODRIGUEZ, Martha E. , WONG, Christina E.
IPC分类号： C07D401/14 , C07D403/04 , C07D451/04 , C07D471/10 , C07D491/107 , C07D519/00 , A61K31/53 , A61P35/00 , C07D513/10
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9.发明授权SUBSTITUTED N-(1H-INDAZOL-4-YL)IMIDAZO[1, 2-A]PYRIDINE-3- CARBOXAMIDE COMPOUNDS AS CFMS INHIBITORS 有权取代的N-（1H-吲唑-4-基）咪唑并+ AFS-1，2-A + AF0 - 吡啶-3-甲酰胺作为抑制剂CFMS
公开(公告)号：EP2516433B1
公开(公告)日：2014-05-21
申请号：EP10798683.8
申请日：2010-12-20
发明人： BOYS, Mark Laurence , BRADLEY, Michael F. , DELISLE, Robert Kirk , HENNINGS, D. David , KENNEDY, April L. , MARMSATER, Fredrik P. , MEDINA, Matthew David , MUNSON, Mark C. , RAST, Bryson , RIZZI, James P. , RODRIGUEZ, Martha E. , TOPALOV, George T. , ZHAO, Qian
IPC分类号： C07D471/04 , C07D519/00 , A61K31/437 , A61K31/4985 , A61P9/00 , A61P19/08 , A61P29/00 , A61P35/00
CPC分类号： C07D471/04 , C07D519/00
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