公开(公告)号：EP4438594A1

公开(公告)日：2024-10-02

申请号：EP22887172.9

申请日：2022-10-28

申请人： Mitsubishi Tanabe Pharma Corporation

发明人： HAYASHI Norimitsu ,  IKUBO Masaya ,  NAKAO Akira ,  OGATA Shingo ,  NAGAOKA Minami ,  FUKUNAGA Kenji ,  KANNO Rentarou ,  YAMADA Takahiro

IPC分类号： C07D205/12 ,  A61K31/397 ,  A61K31/4025 ,  A61K31/4035 ,  A61K31/416 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/429 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/4427 ,  A61K31/4436 ,  A61K31/4725 ,  A61K31/4985 ,  A61K31/502 ,  A61K31/506 ,  A61K31/5355 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55 ,  A61K31/551

CPC分类号： A61K31/397 ,  A61K31/4025 ,  A61K31/4035 ,  A61K31/416 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/429 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/4427 ,  A61K31/4436 ,  A61K31/4725 ,  A61K31/4985 ,  A61K31/502 ,  A61K31/506 ,  A61K31/5355 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55 ,  A61K31/551 ,  A61K31/553 ,  A61K31/554 ,  A61P25/04 ,  A61P25/16 ,  A61P25/20 ,  A61P25/24 ,  A61P25/28 ,  A61P43/00 ,  C07D205/12 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00

摘要： The present invention provides a novel spiro compound or a pharmacologically acceptable salt thereof that has a TRH-DE inhibitory activity and is useful for preventing or treating various diseases associated with TRH and/or symptoms associated therewith, a method for producing the same, a use thereof, and a pharmaceutical composition containing the compound or the pharmacologically acceptable salt thereof as an active ingredient.
There is provided a compound represented by the following Formula [I]:

wherein,
a ring A represents an aryl group which may be substituted, a heteroaryl group which may be substituted, or an aliphatic heterocyclyl group which may be substituted, and
R1 and R2 represent, indipendently, an alkyl group which may be substituted, a cycloalkyl group which may be substituted, an alkenyl group which may be substituted, a cycloalkenyl group which may be substituted, an alkynyl group which may be substituted, an aryl group which may be substituted, a heteroaryl group which may be substituted, an aliphatic heterocyclyl group which may be substituted and may have a double bond in a part of a ring, an amino group which may be substituted, an alkoxy group which may be substituted, or an alkylthio group which may be substituted, or a group in which R1 and R2 together form a ring,
or a pharmacologically acceptable salt thereof.