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公开(公告)号：EP3623472A1
公开(公告)日：2020-03-18
申请号：EP18798161.8
申请日：2018-05-11
发明人： TATENO, Toshihiro , YOKOTA, Motoi , HIDESAKI, Tomonori , ARAKI, Tadashi , SHINDO, Atsunori , MATSUMOTO, Yoshiko , MIYATA, Toshio , HONJO, Masaru
摘要： A recombinant microorganism includes a gene encoding a pyridoxine dehydrogenase, a gene encoding a pyridoxamine synthetase having an enzymatic activity of synthesizing pyridoxamine from pyridoxal, and a gene encoding an amino acid regeneration enzyme having an enzymatic activity of regenerating an amino acid consumed by the pyridoxamine synthetase, in which at least two of the gene encoding the pyridoxine dehydrogenase, the gene encoding the pyridoxamine synthetase, or the gene encoding the amino acid regeneration enzyme, are introduced from outside of a bacterial cell, or are endogenous to the bacterial cell and have an enhanced expression. In addition, a recombinant microorganism into which a gene encoding a pyridoxine dehydrogenase is introduced is provided.
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2.发明公开
公开(公告)号：EP3623471A1
公开(公告)日：2020-03-18
申请号：EP18797661.8
申请日：2018-05-11
发明人： TATENO, Toshihiro , HIDESAKI, Tomonori , ARAKI, Tadashi , SHINDO, Atsunori , MATSUMOTO, Yoshiko , MIYATA, Toshio , HONJO, Masaru
摘要： Provided are a recombinant microorganism comprising: a gene encoding a pyridoxine oxidase; and a gene encoding a pyridoxamine synthetase having an enzymatic activity of synthesizing pyridoxamine from pyridoxal, in which each of the gene encoding a pyridoxine oxidase and the gene encoding a pyridoxamine synthetase is introduced from outside of a bacterial cell, or is endogenous to the bacterial cell and has an enhanced expression, and a method of producing pyridoxamine or a salt thereof from pyridoxine or a salt thereof using the recombinant microorganism.
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