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公开(公告)号：EP3623472A1
公开(公告)日：2020-03-18
申请号：EP18798161.8
申请日：2018-05-11
发明人： TATENO, Toshihiro , YOKOTA, Motoi , HIDESAKI, Tomonori , ARAKI, Tadashi , SHINDO, Atsunori , MATSUMOTO, Yoshiko , MIYATA, Toshio , HONJO, Masaru
摘要： A recombinant microorganism includes a gene encoding a pyridoxine dehydrogenase, a gene encoding a pyridoxamine synthetase having an enzymatic activity of synthesizing pyridoxamine from pyridoxal, and a gene encoding an amino acid regeneration enzyme having an enzymatic activity of regenerating an amino acid consumed by the pyridoxamine synthetase, in which at least two of the gene encoding the pyridoxine dehydrogenase, the gene encoding the pyridoxamine synthetase, or the gene encoding the amino acid regeneration enzyme, are introduced from outside of a bacterial cell, or are endogenous to the bacterial cell and have an enhanced expression. In addition, a recombinant microorganism into which a gene encoding a pyridoxine dehydrogenase is introduced is provided.
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2.发明公开
公开(公告)号：EP3623471A1
公开(公告)日：2020-03-18
申请号：EP18797661.8
申请日：2018-05-11
发明人： TATENO, Toshihiro , HIDESAKI, Tomonori , ARAKI, Tadashi , SHINDO, Atsunori , MATSUMOTO, Yoshiko , MIYATA, Toshio , HONJO, Masaru
摘要： Provided are a recombinant microorganism comprising: a gene encoding a pyridoxine oxidase; and a gene encoding a pyridoxamine synthetase having an enzymatic activity of synthesizing pyridoxamine from pyridoxal, in which each of the gene encoding a pyridoxine oxidase and the gene encoding a pyridoxamine synthetase is introduced from outside of a bacterial cell, or is endogenous to the bacterial cell and has an enhanced expression, and a method of producing pyridoxamine or a salt thereof from pyridoxine or a salt thereof using the recombinant microorganism.
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公开(公告)号：EP2543736B1
公开(公告)日：2019-10-30
申请号：EP11750583.4
申请日：2011-02-25
发明人： HIDESAKI, Tomonori , NATSUJI, Akiko , NAKAGAWA, Toshihiko , KUWAMURA, Goro , HASEGAWA, Daisuke , YAMASAKI, Satoshi , SATO, Kuniaki , TAKEUCHI, Hiroshi
IPC分类号： C12P13/00 , C07C263/00 , C07C263/04 , C07C263/10 , C08G18/73 , C12N15/09 , C07C211/09
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公开(公告)号：EP2949751A1
公开(公告)日：2015-12-02
申请号：EP14743436.9
申请日：2014-01-23
CPC分类号： C12P19/32 , C12N9/0006 , C12N9/88 , C12N9/93 , C12N15/52 , C12P1/04 , C12P7/04 , C12P7/28 , C12P7/42 , C12P7/44 , C12P7/46 , C12P7/48 , C12P7/625 , C12P13/14 , C12Y101/0106 , C12Y101/01081 , C12Y401/01047 , C12Y401/03024 , C12Y602/01009
摘要： An acetyl-CoA producing microorganism obtained by imparting at least one enzymatic activity selected from the group consisting of malate thiokinase, malyl-CoA lyase, glyoxylate carboligase, 2-hydroxy-3-oxopropionate reductase, and hydroxypyruvate reductase, to a microorganism that does not have any of the following (a), (b), (c), (d) or (e): (a) a carbon dioxide fixation cycle including an enzymatic reaction from malonyl-CoA to malonate semialdehyde or 3-hydroxypropionate; (b) a carbon dioxide fixation cycle including an enzymatic reaction from acetyl-CoA and CO 2 to pyruvate; (c) a carbon dioxide fixation cycle including an enzymatic reaction from crotonyl-CoA and CO 2 to ethylmalonyl-CoA or glutaconyl-CoA; (d) a carbon dioxide fixation cycle including an enzymatic reaction from CO 2 to formate; or (e) at least one selected from the group consisting of malate thiokinase and malyl-CoA lyase.
摘要翻译： 通过赋予选自苹果酸硫激酶，丙烯酰辅酶A裂解酶，乙醛酸溶血酸酶，2-羟基-3-氧代丙酸盐还原酶和羟丙基还原酶的至少一种酶活性而获得的乙酰辅酶A产生微生物， 具有以下（a），（b），（c），（d）或（e）中任一项：（a）二氧化碳固定循环，其包括从丙二酰辅酶A到丙二酸二醛或3-羟基丙酸酯的酶反应; （b）二氧化碳固定循环，包括从乙酰辅酶A和CO 2到丙酮酸的酶反应; （c）二氧化碳固定循环，其包括从巴豆酰辅酶A和CO 2到乙基丙二酰辅酶A或戊二酰辅酶A的酶反应; （d）二氧化碳固定循环，其包括从CO 2到甲酸盐的酶反应; 或（e）选自苹果酸硫激酶和苹果酰CoA裂解酶中的至少一种。
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公开(公告)号：EP2806026B1
公开(公告)日：2018-12-26
申请号：EP13738315.4
申请日：2013-01-17
IPC分类号： C12N9/88 , C07C263/10 , C07C263/14 , C12P13/00
CPC分类号： C12P13/001 , C07C209/68 , C07C263/10 , C12N9/88 , C12P13/00 , C12Y401/01018 , C07C211/09 , C07C265/14
摘要： A mutant lysine decarboxylase is produced by replacing at least one of the amino-acids in the amino acid sequence shown in sequence ID No.4 of the sequence listing with another amino-acid.
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6.发明公开MICROORGANISM FOR PRODUCTION OF CHEMICALS DERIVED FROM ACETYL-COA 有权MIKORORGANISMUS ZUR HERSTELLUNG VON AUS ACETYL-COA GEWONNENEN CHEMIKALIEN
公开(公告)号：EP2948539A1
公开(公告)日：2015-12-02
申请号：EP14743597.8
申请日：2014-01-23
CPC分类号： C12P19/32 , C12N9/88 , C12N9/93 , C12N15/52 , C12P1/04 , C12P13/14 , C12Y401/03024 , C12Y602/01009
摘要： Disclosed is an acetyl-CoA-producing microorganism, which is obtained by imparting malate thiokinase and malyl-CoA lyase enzymatic activities to a microorganism having none of the following (a), (b), (c) or (d), without imparting any of (a), (b), (c) or (d), or, even when one or more of (a), (b), (c) or (d) are imparted, not allowing the functions thereof to be exerted: (a) a carbon dioxide fixation cycle having an enzymatic reaction from malonyl-CoA to malonate semialdehyde or 3-hydroxypropionate, (b) a carbon dioxide fixation cycle having an enzymatic reaction from acetyl-CoA and CO
2 to pyruvate, (c) a carbon dioxide fixation cycle having an enzymatic reaction from crotonyl-CoA and CO
2 to ethylmalonyl-CoA or glutaconyl-CoA or (d) a carbon dioxide fixation cycle having an enzymatic reaction from CO
2 to formate.摘要翻译： 公开了通过赋予没有以下（a），（b），（c）或（d）的微生物赋予苹果酸硫激酶和丙烯酰辅酶A裂解酶酶活性而获得的乙酰辅酶A微生物，而不赋予 （a），（b），（c）或（d）中的任何一个，或者即使赋予（a），（b），（c）或（d）中的一个或多个也不允许其功能 （a）具有从丙二酰辅酶A到丙二酸半醛或3-羟基丙酸酯的酶反应的二氧化碳固定循环，（b）具有从乙酰辅酶A和CO 2到丙酮酸的酶反应的二氧化碳固定循环，（c ）具有从巴豆酰CoA和CO 2到乙基丙二酰CoA或戊烯酰辅酶A的酶反应的二氧化碳固定循环，或（d）具有从CO 2到甲酸的酶反应的二氧化碳固定循环。
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公开(公告)号：EP2948539B1
公开(公告)日：2017-10-18
申请号：EP14743597.8
申请日：2014-01-23
CPC分类号： C12P19/32 , C12N9/88 , C12N9/93 , C12N15/52 , C12P1/04 , C12P13/14 , C12Y401/03024 , C12Y602/01009
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公开(公告)号：EP2738247A1
公开(公告)日：2014-06-04
申请号：EP12819719.1
申请日：2012-07-27
发明人： FUJII, Ryota , SHIRAI, Tomokazu , ARAKI, Tadashi , AMANO, Koh , MATSUMOTO, Yoshiko , TATENO, Toshihiro , TAKEBAYASHI, Nozomi , MORISHIGE, Takashi , TAKAHASHI, Hitoshi , WADA, Mitsufumi , SHIMIZU, Hiroshi , FURUSAWA, Chikara , HIRASAWA, Takashi , HIDESAKI, Tomonori , ENDO, Ayako , JÜRGEN-LOHMANN, Dominik Lukas , MADHAVAN, Anjali , CHONG, SU SUN
CPC分类号： C12P19/40 , C12N1/20 , C12N9/0006 , C12N9/88 , C12N9/93 , C12P7/04 , C12P7/28 , C12P13/14 , C12P19/32 , C12Y101/0106 , C12Y101/01081 , C12Y401/01047 , C12Y401/03024 , C12Y602/01009
摘要： An acetyl-CoA-producing microorganism, which is capable of efficiently synthesizing acetyl-CoA using carbon dioxide, and a substance production method using the same are provided. An acetyl-CoA-producing microorganism including an acetyl-CoA production cycle obtained by imparting at least one type of enzymatic activity selected from the group consisting of malate thiokinase, malyl-CoA lyase, glyoxylate carboligase, 2-hydroxy-3-oxopropionate reductase, and hydroxypyruvate reductase, to a microorganism.
摘要翻译： 提供了能够使用二氧化碳有效地合成乙酰辅酶A的乙酰辅酶A生产微生物和使用其的物质制备方法。 一种乙酰辅酶A生产微生物，其包括通过赋予选自苹果酸硫激酶，苹果酰辅酶A裂解酶，乙醛酸卡巴肼，2-羟基-3-氧代丙酸酯还原酶中的至少一种酶活性而获得的乙酰辅酶A生产循环， 和羟丙酮酸还原酶。
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9.发明授权DNA ENCODING NOVEL ENZYME HAVING D-SERINE SYNTHASE ACTIVITY, METHOD OF PRODUCING THE ENZYME AND METHOD OF PRODUCING D-SERINE BY USING THE SAME 有权用于d SERIN合酶编码DNA，PROCESS FOR生产该酶及其制造方法D-SERIN THEREOF使用一种新的酶
公开(公告)号：EP1806401B1
公开(公告)日：2013-07-31
申请号：EP05793824.3
申请日：2005-10-07
发明人： ARAKI, Tadashi , HIDESAKI, Tomonori , WATANABE, Seiichi , NISHIDA, Keita , NAGAHARA, Kiyoteru , KOITO, Mitsuo
CPC分类号： C12P13/06 , C12N9/1014
摘要： This invention relates to DNA encoding a novel enzyme having activity of synthesizing D-serine from formaldehyde and glycine, recombinant DNA constructed by integrating such DNA into a vector, a transformant transformed with the recombinant DNA, and a method for producing D-serine from formaldehyde and glycine with the use of the enzyme.
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公开(公告)号：EP2216410A1
公开(公告)日：2010-08-11
申请号：EP08835248.9
申请日：2008-09-30
发明人： HIDESAKI, Tomonori
CPC分类号： C12P13/222 , C12P13/225
摘要： Disclosed is a method for producing a β-amino acid comprising a step of synthesizing a β-amino acid from an α-amino acid in the presence of an amino acid aminomutase. In this method, a β-amino acid is precipitated as a solid in the reaction solution.
摘要翻译： 公开了一种生产2-氨基酸的方法，包括在氨基酸氨基变位酶存在下从± - 氨基酸合成2-氨基酸的步骤。 在该方法中，将2-氨基酸作为固体沉淀在反应溶液中。
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