-
公开(公告)号：EP2473491A1
公开(公告)日：2012-07-11
申请号：EP10722268.9
申请日：2010-06-01
发明人： NISHIDA, Hidemitsu , SAITOH, Fumihiko , HIRABAYASHI, Tomokazu , CHACKALAMANNIL, Samuel , CHAN, Tin-Yau , CHELLIAH, Mariappan, V. , CLASBY, Martin, C. , DWYER, Michael, P. , GREENLEE, William, J. , XIA, Yan , NEELAMKAVIL, Santhosh , SHAH, Unmesh, G.
IPC分类号： C07D265/32 , C07D413/04 , C07D413/12 , C07D413/14 , A61K31/5377 , A61P7/02
CPC分类号： C07D413/12 , C07D265/32 , C07D413/04 , C07D413/14
摘要： The present invention provides compounds having the formula (I) or a pharmaceutically acceptable salt or a solvate thereof, pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes.
摘要翻译： 本发明提供具有式（I）的化合物或其药学上可接受的盐或溶剂化物，包含一种或多种所述化合物的药物组合物，以及使用所述化合物治疗或预防血栓形成，栓塞，高凝血或纤维化改变的方法。
-
公开(公告)号：EP2473491B1
公开(公告)日：2013-07-17
申请号：EP10722268.9
申请日：2010-06-01
发明人： NISHIDA, Hidemitsu , SAITOH, Fumihiko , HIRABAYASHI, Tomokazu , CHACKALAMANNIL, Samuel , CHAN, Tin-Yau , CHELLIAH, Mariappan, V. , CLASBY, Martin, C. , DWYER, Michael, P. , GREENLEE, William, J. , XIA, Yan , NEELAMKAVIL, Santhosh , SHAH, Unmesh, G.
IPC分类号： C07D265/32 , C07D413/04 , C07D413/12 , C07D413/14 , A61K31/5377 , A61P7/02
CPC分类号： C07D413/12 , C07D265/32 , C07D413/04 , C07D413/14
-
公开(公告)号：EP2148869A1
公开(公告)日：2010-02-03
申请号：EP08742980.9
申请日：2008-04-17
申请人： Schering Corporation
发明人： BOYLE, Craig D. , NEELAMKAVIL, Santhosh, Francis , CHACKALAMANNIL, Samuel , NEUSTADT, Bernard, R. , HAO, Jinsong , SHAH, Unmesh, G. , HARRIS, Joel , LIU, Hong , STAMFORD, Andrew, W.
IPC分类号： C07D401/04 , C07D487/04 , A61K31/519 , A61P3/10
CPC分类号： C07D401/04 , C07D487/04
摘要： The present invention relates to Pyrimidinone Derivatives, compositions comprising a Pyrimidinone Derivative, and methods of using the Pyrimidinone Derivatives for treating or preventing obesity, diabetes, a metabolic disorder, a cardiovascular disease or a disorder related to the activity of G protein-coupled receptor 119 ('GPR119') in a patient.
摘要翻译： 本发明涉及嘧啶酮衍生物，包含嘧啶酮衍生物的组合物，以及使用嘧啶酮衍生物治疗或预防肥胖，糖尿病，代谢病症，心血管疾病或与G蛋白偶联受体119活性有关的病症的方法 （'GPR119'）在患者中。
-
公开(公告)号：EP1448565B1
公开(公告)日：2009-12-30
申请号：EP02784568.4
申请日：2002-11-26
申请人： Schering Corporation
发明人： BOYLE, Craig, D. , CHACKALAMANNIL, Samuel , GREENLEE, William, J. , SHAH, Unmesh, G. , XIA, Yan
IPC分类号： C07D487/14 , A61K31/505 , A61P25/00
CPC分类号： C07D487/14
摘要： Disclosed herein are compounds having the structural formula (A) including pharmaceutically acceptable salts or solvates of said compound, wherein X, Y, Q and R are as defined in the specification; pharmaceutical compositions thereof; methods of treating central nervous system diseases by administering the compound of the present invention to a patient in need of such treatment, and processes for preparing the compound of this invention.
-
5.发明公开BICYCLIC PIPERIDINE AND PIPERAZINE DERIVATIVES AS GPCR MODULATORS FOR THE TREATMENT OF OBESITY, DIABETES AND OTHER METABOLIC DISORDERS 有权AS GPCR调节剂的双环哌啶和哌嗪衍生物用于治疗肥胖，糖尿病和其他代谢紊乱的治疗
公开(公告)号：EP2414348A1
公开(公告)日：2012-02-08
申请号：EP10713071.8
申请日：2010-04-01
申请人： Schering Corporation
发明人： BOYLE, Craig, D. , LANKIN, Claire, M. , SHAH, Unmesh, G. , GREENLEE, William, J. , CHACKALAMANNIL, Samuel
IPC分类号： C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , A61K31/506 , A61K31/513 , A61P3/00
CPC分类号： C07D401/14 , C07D401/12 , C07D403/06 , C07D403/12
摘要： The present invention relates to Bicyclic Piperidine and Piperazine Derivatives, compositions comprising a Bicyclic Piperidine and Piperazine Derivative, and methods of using the Bicyclic Piperidine and Piperazine Derivatives for treating or preventing obesity, diabetes, a metabolic disorder, a cardiovascular disease or a disorder related to the activity of a GPCR in a patient.
-
6.发明公开2-ALKYNYL-AND 2-ALKENYL-PYRAZOLO- [4,3-E] -1,2,4-TRIAZOLO- [1,5-C] -PYRIMIDINE ADENOSINE A sb 2A /sb RECEPTOR ANTAGONISTS 有权2-烯丙基 - 二烯丙基 - 吡唑并[4,3-E] -1,2,4-三唑并[1,5-C] - 嘧啶并[d]恶嗪酮A2A反应物
公开(公告)号：EP1622912A2
公开(公告)日：2006-02-08
申请号：EP04760128.1
申请日：2004-04-21
申请人： SCHERING CORPORATION
发明人： NEUSTADT, Bernard, R. , HAO, Jinsong , LIU, Hong , BOYLE, Craig, D. , CHACKALAMANNIL, Samuel , SHAH, Unmesh, G. , STAMFORD, Andrew
IPC分类号： C07D487/14 , A61K31/519 , A61P25/16
CPC分类号： C07D487/14
摘要： Compounds having the structural formula (I) or a pharmaceutically acceptable salt thereof, wherein R is R1, R2, R3, R4 and R5 are H, alkyl or alkoxyalkyl; R6 is H, alkyl, hydroxyalkyl or -CH2F; R7, R8 and R9 are H, alkyl, alkoxy, alkylthio, alkoxyalkyl, halo or -CF3; and Z is optionally substituted aryl, heteroaryl or heteroaryl-alkyl are disclosed. Also disclosed is the use of compounds of formula I in the treatment of central nervous system diseases, in particular Parkinson's disease, alone or in combination with other agents for treating Parkinson's disease, and pharmaceutical compositions comprising them.
-
7.发明授权2-HETEROARYL-PYRAZOLO-[4, 3-e]-1, 2, 4-TRIAZOLO-[1,5-c]-PYRIMIDINE AS ADENOSINE A2a RECEPTOR ANTAGONISTS 有权2- HETEROARYLPYRAZOLO并[4,3-E] -1,2，4-三唑并[1,5-C]嘧啶作为腺苷A2A受体的拮抗剂
公开(公告)号：EP1934227B1
公开(公告)日：2011-12-21
申请号：EP06803715.9
申请日：2006-09-15
申请人： Schering Corporation
发明人： NEUSTADT, Bernard, R. , BOYLE, Craig, D. , CHACKALAMANNIL, Samuel , HARRIS, Joel, M. , LANKIN, Claire, M. , LIU, Hong , SHAH, Unmesh, G. , STAMFORD, Andrew, W.
IPC分类号： C07D487/14 , A61K31/519 , A61P25/00
CPC分类号： C07D487/14
摘要： Compounds having the structural formula (I) or a pharmaceutically acceptable salt thereof, wherein R is R1-isoxazolyl, R1-oxadiazolyl, R1-dihydrofuranyl, R1-pyrazolyl, R1-imidazolyl, R1-pyrazinyl or R1-pyrimidinyl; R1 is 1 , 2 or 3 substituents selected from H, alkyl, alkoxy and halo; Z is optionally substituted-aryl, or optionally substituted-heteroaryl; are disclosed, as well as their use in the treatment of central nervous system diseases, in particular Parkinson's disease and Extra Pyramidal Syndrome, pharmaceutical compositions comprising them, and combinations with other agents.
-
公开(公告)号：EP2148870A1
公开(公告)日：2010-02-03
申请号：EP08742985.8
申请日：2008-04-17
申请人： Schering Corporation
发明人： BOYLE, Craig, D. , CHACKALAMANNIL, Samuel , LANKIN, Claire, M. , SHAH, Unmesh, G. , NEUSTADT, Bernard, R. , LIU, Hong , STAMFORD, Andrew, W.
IPC分类号： C07D401/04 , A61K31/519 , A61P3/10
CPC分类号： C07D401/04
摘要： The present invention relates to Pyrimidinone Derivatives, compositions comprising a Pyrimidinone Derivative, and methods of using the Pyrimidinone Derivatives for treating or preventing obesity, diabetes, a metabolic disease, a cardiovascular disease or a disorder related to the activity of GPR119 in a patient.
摘要翻译： 本发明涉及嘧啶酮衍生物，包含嘧啶酮衍生物的组合物以及使用该嘧啶酮衍生物用于治疗或预防患者中的肥胖症，糖尿病，代谢疾病，心血管疾病或与GPR119活性相关的病症的方法。
-
公开(公告)号：EP1448565A1
公开(公告)日：2004-08-25
申请号：EP02784568.4
申请日：2002-11-26
申请人： SCHERING CORPORATION
发明人： BOYLE, Craig, D. , CHACKALAMANNIL, Samuel , GREENLEE, William, J. , SHAH, Unmesh, G. , XIA, Yan
IPC分类号： C07D487/14 , A61K31/505 , A61P25/00
CPC分类号： C07D487/14
摘要： Disclosed herein are compounds having the structural formula (A) including pharmaceutically acceptable salts or solvates of said compound, wherein X, Y, Q and R are as defined in the specification; pharmaceutical compositions thereof; methods of treating central nervous system diseases by administering the compound of the present invention to a patient in need of such treatment, and processes for preparing the compound of this invention.
-
10.发明公开BRIDGED BICYCLIC HETEROCYCLE DERIVATIVES AND METHODS OF USE THEREOF 审中-公开桥双环HETEROCYCLUSDERIVATE和申请流程。
公开(公告)号：EP2414334A1
公开(公告)日：2012-02-08
申请号：EP10713072.6
申请日：2010-04-01
申请人： Schering Corporation
发明人： NEELAMKAVIL, Santhosh, Francis , NEUSTADT, Bernard, R. , STAMFORD, Andrew , XIA, Yan , HARRIS, Joel, M. , BOYLE, Craig, D. , CHACKALAMANNIL, Samuel , BISWAS, Dipshikha , LIU, Hong , HAO, Jinsong , LANKIN, Claire, M. , SHAH, Unmesh, G.
IPC分类号： C07D221/22 , C07D451/06 , C07D471/08 , C07D471/20 , C07D487/08 , C07D491/08 , C07D495/08 , C07D498/08 , A61K31/439 , A61K31/506 , A61K31/537 , A61P3/00
CPC分类号： C07D498/08 , C07D401/12 , C07D451/02 , C07D471/08 , C07D487/08 , C07D491/08 , C07D491/113 , C07D495/08
摘要： The present invention relates to Bridged Bicyclic Heterocycle Derivatives, compositions comprising a Bridged Bicyclic Heterocycle Derivative, and methods of using the Bridged Bicyclic Heterocycle Derivatives for treating or preventing obesity, diabetes, a metabolic disorder, a cardiovascular disease or a disorder related to the activity of a GPCR in a patient.
-
-
-
-
-
-
-
-
-
搜索结果
17 条记录 (耗时 0.028 秒)
