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公开(公告)号：EP2473491A1
公开(公告)日：2012-07-11
申请号：EP10722268.9
申请日：2010-06-01
发明人： NISHIDA, Hidemitsu , SAITOH, Fumihiko , HIRABAYASHI, Tomokazu , CHACKALAMANNIL, Samuel , CHAN, Tin-Yau , CHELLIAH, Mariappan, V. , CLASBY, Martin, C. , DWYER, Michael, P. , GREENLEE, William, J. , XIA, Yan , NEELAMKAVIL, Santhosh , SHAH, Unmesh, G.
IPC分类号： C07D265/32 , C07D413/04 , C07D413/12 , C07D413/14 , A61K31/5377 , A61P7/02
CPC分类号： C07D413/12 , C07D265/32 , C07D413/04 , C07D413/14
摘要： The present invention provides compounds having the formula (I) or a pharmaceutically acceptable salt or a solvate thereof, pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes.
摘要翻译： 本发明提供具有式（I）的化合物或其药学上可接受的盐或溶剂化物，包含一种或多种所述化合物的药物组合物，以及使用所述化合物治疗或预防血栓形成，栓塞，高凝血或纤维化改变的方法。
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公开(公告)号：EP2373634A1
公开(公告)日：2011-10-12
申请号：EP09768572.1
申请日：2009-12-03
发明人： NISHIDA, Hidemitsu , SAITOH, Fumihiko , HIRABAYASHI, Tomokazu , CHACKALAMANNIL, Samuel , CHAN, Tin-Yau , CHELLIAH, Mariappan, V. , CLASBY, Martin, C. , DWYER, Michael, P. , GREENLEE, William, J. , XIA, Yan
IPC分类号： C07D265/30 , C07D265/32 , C07D267/10 , C07D279/06 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/04 , A61K31/4725 , A61K31/54 , A61K31/553 , A61K31/5355 , A61P7/00
CPC分类号： C07D401/12 , C07D265/30 , C07D265/32 , C07D267/10 , C07D279/06 , C07D413/12 , C07D413/14 , C07D417/04
摘要： The present invention provides a compound of Formula (I) as described herein, or a pharmaceutically acceptable salt or a solvate thereof. The present invention also provides pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing a thromboses, embolisms, hypercoagulability or fibrotic changes.
摘要翻译： 本发明提供如本文所述的式（I）化合物或其药学上可接受的盐或溶剂合物。 本发明还提供了包含一种或多种所述化合物的药物组合物，以及使用所述化合物治疗或预防血栓形成，栓塞，高凝状态或纤维化改变的方法。
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公开(公告)号：EP2473491B1
公开(公告)日：2013-07-17
申请号：EP10722268.9
申请日：2010-06-01
发明人： NISHIDA, Hidemitsu , SAITOH, Fumihiko , HIRABAYASHI, Tomokazu , CHACKALAMANNIL, Samuel , CHAN, Tin-Yau , CHELLIAH, Mariappan, V. , CLASBY, Martin, C. , DWYER, Michael, P. , GREENLEE, William, J. , XIA, Yan , NEELAMKAVIL, Santhosh , SHAH, Unmesh, G.
IPC分类号： C07D265/32 , C07D413/04 , C07D413/12 , C07D413/14 , A61K31/5377 , A61P7/02
CPC分类号： C07D413/12 , C07D265/32 , C07D413/04 , C07D413/14
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公开(公告)号：EP2373634B1
公开(公告)日：2015-11-11
申请号：EP09768572.1
申请日：2009-12-03
发明人： NISHIDA, Hidemitsu , SAITOH, Fumihiko , HIRABAYASHI, Tomokazu , CHACKALAMANNIL, Samuel , CHAN, Tin-Yau , CHELLIAH, Mariappan, V. , CLASBY, Martin, C. , DWYER, Michael, P. , GREENLEE, William, J. , XIA, Yan
IPC分类号： C07D265/30 , C07D265/32 , C07D267/10 , C07D279/06 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/04 , A61K31/4725 , A61K31/54 , A61K31/553 , A61K31/5355 , A61P7/00
CPC分类号： C07D401/12 , C07D265/30 , C07D265/32 , C07D267/10 , C07D279/06 , C07D413/12 , C07D413/14 , C07D417/04
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公开(公告)号：EP2963037B1
公开(公告)日：2019-03-27
申请号：EP14756804.2
申请日：2014-02-26
IPC分类号： C07D471/04 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/5377 , A61P3/04 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/32 , A61P25/36 , A61P43/00 , C07D401/04 , C07D417/04 , C07D403/04
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公开(公告)号：EP2963037A1
公开(公告)日：2016-01-06
申请号：EP14756804.2
申请日：2014-02-26
IPC分类号： C07D471/04 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/5377 , A61P3/04 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/32 , A61P25/36 , A61P43/00 , C07D401/04 , C07D417/04
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D401/04 , C07D403/04 , C07D417/04
摘要： It has been desired to develop a pharmaceutical composition, which is used in agents for preventing and/or treating various diseases related to PDE10 (e.g. mental disorder and neurodegenerative disorder). The present invention provides: compounds having PDE10 inhibitory effect, in particular, compounds having a 4-heteroarylpyrazole-5-carboxylic acid amide structure represented by the following formula (I), or their pharmaceutically acceptable salts, or their solvates; pharmaceutical compositions comprising, as active ingredients, the compounds, or their pharmaceutically acceptable salts, or their solvates; and medical use of the compounds, or their pharmaceutically acceptable salts, or their solvates.
摘要翻译： 期望开发一种药物组合物，其用于预防和/或治疗与PDE10相关的各种疾病（例如精神障碍和神经变性疾病）的药剂中。 本发明提供：具有PDE10抑制作用的化合物，特别是具有下述式（I）所示的4-杂芳基吡唑-5-甲酰胺结构的化合物或它们的药学上可接受的盐或它们的溶剂合物。 包含作为活性成分的化合物或其药学上可接受的盐或其溶剂合物的药物组合物; 和化合物或其药学上可接受的盐或其溶剂合物的医学用途。
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