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公开(公告)号：EP2473491A1
公开(公告)日：2012-07-11
申请号：EP10722268.9
申请日：2010-06-01
发明人： NISHIDA, Hidemitsu , SAITOH, Fumihiko , HIRABAYASHI, Tomokazu , CHACKALAMANNIL, Samuel , CHAN, Tin-Yau , CHELLIAH, Mariappan, V. , CLASBY, Martin, C. , DWYER, Michael, P. , GREENLEE, William, J. , XIA, Yan , NEELAMKAVIL, Santhosh , SHAH, Unmesh, G.
IPC分类号： C07D265/32 , C07D413/04 , C07D413/12 , C07D413/14 , A61K31/5377 , A61P7/02
CPC分类号： C07D413/12 , C07D265/32 , C07D413/04 , C07D413/14
摘要： The present invention provides compounds having the formula (I) or a pharmaceutically acceptable salt or a solvate thereof, pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes.
摘要翻译： 本发明提供具有式（I）的化合物或其药学上可接受的盐或溶剂化物，包含一种或多种所述化合物的药物组合物，以及使用所述化合物治疗或预防血栓形成，栓塞，高凝血或纤维化改变的方法。
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公开(公告)号：EP2373634A1
公开(公告)日：2011-10-12
申请号：EP09768572.1
申请日：2009-12-03
发明人： NISHIDA, Hidemitsu , SAITOH, Fumihiko , HIRABAYASHI, Tomokazu , CHACKALAMANNIL, Samuel , CHAN, Tin-Yau , CHELLIAH, Mariappan, V. , CLASBY, Martin, C. , DWYER, Michael, P. , GREENLEE, William, J. , XIA, Yan
IPC分类号： C07D265/30 , C07D265/32 , C07D267/10 , C07D279/06 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/04 , A61K31/4725 , A61K31/54 , A61K31/553 , A61K31/5355 , A61P7/00
CPC分类号： C07D401/12 , C07D265/30 , C07D265/32 , C07D267/10 , C07D279/06 , C07D413/12 , C07D413/14 , C07D417/04
摘要： The present invention provides a compound of Formula (I) as described herein, or a pharmaceutically acceptable salt or a solvate thereof. The present invention also provides pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing a thromboses, embolisms, hypercoagulability or fibrotic changes.
摘要翻译： 本发明提供如本文所述的式（I）化合物或其药学上可接受的盐或溶剂合物。 本发明还提供了包含一种或多种所述化合物的药物组合物，以及使用所述化合物治疗或预防血栓形成，栓塞，高凝状态或纤维化改变的方法。
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公开(公告)号：EP2373634B1
公开(公告)日：2015-11-11
申请号：EP09768572.1
申请日：2009-12-03
发明人： NISHIDA, Hidemitsu , SAITOH, Fumihiko , HIRABAYASHI, Tomokazu , CHACKALAMANNIL, Samuel , CHAN, Tin-Yau , CHELLIAH, Mariappan, V. , CLASBY, Martin, C. , DWYER, Michael, P. , GREENLEE, William, J. , XIA, Yan
IPC分类号： C07D265/30 , C07D265/32 , C07D267/10 , C07D279/06 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/04 , A61K31/4725 , A61K31/54 , A61K31/553 , A61K31/5355 , A61P7/00
CPC分类号： C07D401/12 , C07D265/30 , C07D265/32 , C07D267/10 , C07D279/06 , C07D413/12 , C07D413/14 , C07D417/04
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公开(公告)号：EP2473491B1
公开(公告)日：2013-07-17
申请号：EP10722268.9
申请日：2010-06-01
发明人： NISHIDA, Hidemitsu , SAITOH, Fumihiko , HIRABAYASHI, Tomokazu , CHACKALAMANNIL, Samuel , CHAN, Tin-Yau , CHELLIAH, Mariappan, V. , CLASBY, Martin, C. , DWYER, Michael, P. , GREENLEE, William, J. , XIA, Yan , NEELAMKAVIL, Santhosh , SHAH, Unmesh, G.
IPC分类号： C07D265/32 , C07D413/04 , C07D413/12 , C07D413/14 , A61K31/5377 , A61P7/02
CPC分类号： C07D413/12 , C07D265/32 , C07D413/04 , C07D413/14
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5.发明公开
公开(公告)号：EP2197842A1
公开(公告)日：2010-06-23
申请号：EP08795611.6
申请日：2008-08-27
申请人： Schering Corporation
发明人： ANILKUMAR, Gopinadhan, N. , BENNETT, Frank , CHAN, Tin-Yau , CHEN, Kevin, X. , SANNIGRAHI, Mousumi , VELAZQUEZ, Francisco , VENKATRAMAN, Srikanth , ZENG, Qingbei , DUCA, Jose, S. , LESBURG, Charles, A. , KOZLOWSKI, Joseph, A. , NJOROGE, F., George , ROSENBLUM, Stuart, B. , SHIH, Neng-Yang , GAVALAS, Stephen, J. , JIANG, Yueheng , PINTO, Patrick, A. , PU, Haiyan , SELYUTIN, Oleg, B. , VIBULBHAN, Bancha , WANG, Li , WU, Wanli , YANG, Weiying , HUANG, Yuhua , HUANG, Hsueh-Cheng , PALERMO, Robert , FELD, Boris
IPC分类号： C07D209/42 , C07D401/04 , C07D401/14 , A61K31/404 , A61P31/12
CPC分类号： C07D417/14 , C07D209/42 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present invention relates to 2,3-Substituted Indole Derivatives, compositions comprising at least one 2,3-Substituted Indole Derivative, and methods of using the 2,3-Substituted Indole Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.
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公开(公告)号：EP1537116B1
公开(公告)日：2010-06-02
申请号：EP03794592.0
申请日：2003-09-03
发明人： GUZI, Timothy, J. , PARUCH, Kamil , DWYER, Michael, P. , DOLL, Ronald, J. , GIRIJAVALLABHAN, Viyyoor, Moopil , MALLAMS, Alan , ALVAREZ, Carmen, S. , KEERTIKAR, Kartik, M. , RIVERA, Jocelyn , CHAN, Tin-Yau , MADISON, Vincent , FISCHMANN, Thierry, O. , DILLARD, Lawrence, W. , TRAN, Vinh, D. , HE, Zhen Min , JAMES, Ray, Anthony , PARK, Haengsoon , PARADKAR, Vidyadhar, M. , HOBBS, Douglas, Walsh
IPC分类号： C07D487/04 , A61K31/519
CPC分类号： C07D487/04
摘要： In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
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公开(公告)号：EP1385870A2
公开(公告)日：2004-02-04
申请号：EP01954764.5
申请日：2001-07-19
发明人： SAKSENA, Anil, K. , GIRIJAVALLABHAN, Viyyoor, Moopil , LOVEY, Raymond, G. , JAO, Edwin, E. , BENNETT, Frank , MC CORMICK, Jinping, L. , WANG, Haiyan , PIKE, Russell, E. , BOGEN, Stephane, L. , CHAN, Tin-Yau , LIU, Yi-Tsung , ZHU, Zhaoning , NJOROGE, F., George , ARASAPPAN, Ashok , PAREKH, Tejal, N. , GANGULY, Ashit, K. , CHEN, Kevin, X. , VENKATRAMAN, Srikanth , VACCARO, Henry, A. , PINTO, Patrick A. , SANTHANAM, Bama , WU, Wanli , HENDRATA, Siska , HUANG, Yuhua , KEMP, Scott Jeffrey , LEVY, ODILE ESTHER , LIM-WILBY, Marguetita , TAMURA, Susan Y.
IPC分类号： C07K1/00
CPC分类号： C07K5/0202 , A61K38/00 , C07K5/0812 , C07K5/0827 , C07K7/02
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
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公开(公告)号：EP2367598A2
公开(公告)日：2011-09-28
申请号：EP09752998.6
申请日：2009-11-17
申请人： Schering Corporation
发明人： TING, Pauline, C. , ASLANIAN, Robert, G. , CAPLEN, Mary Ann , CAO, Jianhua , CHAN, Tin-Yau , KIM, David, Won-Shik , KIM, Hyunjin , KIM, Jae-Hun , KUANG, Rongze , LEE, Joe, F. , SCHWERDT, John, H. , WU, Heping , ZORN, Nicolas
IPC分类号： A61P3/00 , A61P9/00 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , A61K31/422 , A61K31/427
CPC分类号： C07D413/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04
摘要： The present invention relates to novel heterocyclic compounds as diacylglycerol acyltransferase ("DGAT") inhibitors, pharmaceutical compositions comprising the heterocyclic compounds and the use of the compounds for treating or preventing a cardiovascular disease, a metabolic disorder, obesity or an obesity-related disorder, diabetes, dyslipidemia, a diabetic complication, impaired glucose tolerance or impaired fasting glucose. An illustrative compound of the invention is shown below: formula (I).
摘要翻译： 本发明涉及作为二酰甘油酰基转移酶（“DGAT”）抑制剂的新型杂环化合物，包含该杂环化合物的药物组合物以及该化合物用于治疗或预防心血管疾病，代谢病症，肥胖症或肥胖相关病症的用途， 糖尿病，血脂异常，糖尿病并发症，葡萄糖耐量降低或空腹血糖受损。 下面显示了本发明的说明性化合物：式（I）。
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9.发明公开
公开(公告)号：EP2350067A2
公开(公告)日：2011-08-03
申请号：EP09740590.6
申请日：2009-10-14
申请人： Schering Corporation
发明人： PALANI, Anandan , BERLIN, Michael, Y. , ASLANIAN, Robert, G. , VACCARO, Henry, M. , CHAN, Tin-Yau , XIAO, Dong , DEGRADO, Sylvia , RAO, Ashwin, U. , CHEN, Xiao , LEE, Yoon, Joo , SOFOLARIDES, Michael, J. , SHAO, Ning , HUANG, Ying, R. , LIU, Zhidan , WANG, Li Yuan , PU, Haiyan
IPC分类号： C07D417/04 , C07D417/14 , C07D471/10 , C07D487/04 , C07D487/08 , C07D285/135 , C07D271/113 , C07D491/107 , A61K31/4355 , A61K31/437 , A61K31/4439 , A61K31/444 , A61P3/10
CPC分类号： C07D285/135 , C07D271/113 , C07D417/04 , C07D417/14 , C07D471/10 , C07D487/04 , C07D487/08 , C07D491/107
摘要： The present invention relates to novel Pyrrolidine, Piperidine and Piperazine Derivatives, pharmaceutical compositions comprising the Pyrrolidine, Piperidine and Piperazine Derivatives and the use of these compounds for treating or preventing treating allergy, an allergy-induced airway response, congestion, a cardiovascular disease, an inflammatory disease, a gastrointestinal disorder, a neurological disoder, a metabolic disorder, obesity, an obesity-related disorder, diabetes, a diabetic complication, impaired glucose tolerance or impaired fasting glucose.
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10.发明公开3-HETEROCYCLIC SUBSTITUTED INDOLE DERIVATIVES AND METHODS OF USE THEREOF 有权3-杂环取代的吲哚衍生物的应用PROCESS FOR
公开(公告)号：EP2222660A1
公开(公告)日：2010-09-01
申请号：EP08848587.5
申请日：2008-11-13
申请人： Schering Corporation
发明人： CHAN, Tin-Yau , DUCA, Jose, S. , HONG, Liwu , LESBURG, Charles, A. , MCKITTRICK, Brian, A. , PU, Haiyan , WANG, Li , VACCARO, Henry, M.
IPC分类号： C07D401/04 , C07D403/04 , C07D403/14 , C07D487/04 , C07D495/04 , A61K31/505 , A61P31/12
CPC分类号： C07D403/04 , C07D401/04 , C07D403/14 , C07D487/04 , C07D495/04
摘要： The present invention relates to 3-Heterocyclic Substituted Indole Derivatives, compositions comprising at least one 3-Heterocyclic Substituted Indole Derivative, and methods of using the 3-Heterocyclic Substituted Indole Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.
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