公开(公告)号：EP3006562B1

公开(公告)日：2017-12-27

申请号：EP14807339.8

申请日：2014-06-03

申请人： Mogam Biotechnology Institute

发明人： HWANG, Mihee ,  PARK, Kukjin ,  SHIN, Duckhyang ,  LEE, Hyeon ,  KIM, Sooin ,  CHO, Eunyoung ,  KIM, Misuk ,  AHN, Dong Ho

IPC分类号： C12N5/10 ,  C12N5/071 ,  C12N5/02 ,  A61K39/12 ,  A61K39/145 ,  C12N7/00

CPC分类号： C12N5/0686 ,  A61K39/12 ,  A61K39/145 ,  C12N7/00 ,  C12N2500/92 ,  C12N2760/16134 ,  C12N2760/16151 ,  C12N2760/16152 ,  C12N2760/16234 ,  C12N2760/16251 ,  C12N2760/16252

摘要： The present invention relates to a novel MDCK-derived cell line capable of being suspension-cultured in a protein-free medium and a method for proliferating a virus using the MDCK-derived cell line to produce a vaccine. The novel MDCK-derived cell line exhibits high and uniform productivity for various viruses, while causing less viral antigenic variations with low tumorigenicity, and thus can be useful in producing viruses used for vaccines.

公开(公告)号：EP3006562A1

公开(公告)日：2016-04-13

申请号：EP14807339.8

申请日：2014-06-03

申请人： Mogam Biotechnology Institute

发明人： HWANG, Mihee ,  PARK, Kukjin ,  SHIN, Duckhyang ,  LEE, Hyeon ,  KIM, Sooin ,  CHO, Eunyoung ,  KIM, Misuk ,  AHN, Dong Ho

IPC分类号： C12N5/10 ,  C12N5/071 ,  C12N5/02 ,  A61K39/12

CPC分类号： C12N5/0686 ,  A61K39/12 ,  A61K39/145 ,  C12N7/00 ,  C12N2500/92 ,  C12N2760/16134 ,  C12N2760/16151 ,  C12N2760/16152 ,  C12N2760/16234 ,  C12N2760/16251 ,  C12N2760/16252

摘要： The present invention relates to a novel MDCK-derived cell line capable of being suspension-cultured in a protein-free medium and a method for proliferating a virus using the MDCK-derived cell line to produce a vaccine. The novel MDCK-derived cell line exhibits high and uniform productivity for various viruses, while causing less viral antigenic variations with low tumorigenicity, and thus can be useful in producing viruses used for vaccines.

摘要翻译： 本发明涉及能够在无蛋白质培养基中悬浮培养的新型MDCK衍生细胞系和使用MDCK来源的细胞系增殖病毒的方法以产生疫苗。 新型MDCK衍生的细胞系对于各种病毒表现出高且均匀的生产力，同时导致较少的病毒抗原变异和低致瘤性，因此可用于生产用于疫苗的病毒。