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1.发明公开
公开(公告)号：EP2563919A1
公开(公告)日：2013-03-06
申请号：EP10850768.2
申请日：2010-04-26
申请人： Green Cross Corporation , Mogam Biotechnology Research Institute , Industry-Academic Cooperation Foundation, Yonsei University
发明人： KOH, Daekyung , YUN, Seongtae , LEE, Kyuhyun , LEE, Hong-Kyu , HWANG, Mihee , YUN, Chae-Ok , JO, Eui-Cheol
CPC分类号： A61K35/76 , A61K35/13 , A61K35/761 , C12N2830/008
摘要： Provided are tumor-specific promoters, oncolytic virus vectors and a pharmaceutical composition comprising the virus vector. The virus vector comprising the novel tumor-specific promoter shows excellent oncolytic effects on tumor cells, and thus it is useful for treating a cancer.
摘要翻译： 提供了肿瘤特异性启动子，溶瘤病毒载体和包含病毒载体的药物组合物。 包含新型肿瘤特异性启动子的病毒载体对肿瘤细胞显示出优异的溶瘤作用，因此可用于治疗癌症。
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公开(公告)号：EP2563919B1
公开(公告)日：2018-06-13
申请号：EP10850768.2
申请日：2010-04-26
申请人： Green Cross Corporation , Mogam Biotechnology Research Institute , Industry-Academic Cooperation Foundation, Yonsei University
发明人： KOH, Daekyung , YUN, Seongtae , LEE, Kyuhyun , LEE, Hong-Kyu , HWANG, Mihee , YUN, Chae-Ok , JO, Eui-Cheol
CPC分类号： A61K35/76 , A61K35/13 , A61K35/761 , C12N2830/008
摘要： Provided are tumor-specific promoters, oncolytic virus vectors and a pharmaceutical composition comprising the virus vector. The virus vector comprising the novel tumor-specific promoter shows excellent oncolytic effects on tumor cells, and thus it is useful for treating a cancer.
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3.发明授权HEXON ISOLATED FROM SIMIAN ADENOVIRUS SEROTYPE 19, HYPERVARIABLE REGION THEREOF AND CHIMERIC ADENOVIRUS USING THE SAME 有权HEXON从SIMIAN ADENOVIRUS SEROTYPE 19中分离，其超嗜碱性区域和嵌合腺病毒使用相同
公开(公告)号：EP2558481B1
公开(公告)日：2017-12-20
申请号：EP10849873.4
申请日：2010-04-14
发明人： LEE, Kyuhyun , YUN, Seongtae , KOH, Daekyung , LEE, Hong-Kyu , JO, Eui-Cheol
IPC分类号： C07K14/075 , C12N15/34 , C12N15/861
CPC分类号： C12N7/00 , A61K39/0011 , A61K2039/5256 , C07K14/005 , C12N15/86 , C12N2710/10321 , C12N2710/10322 , C12N2710/10332 , C12N2710/10342 , C12N2710/10343 , C12N2710/10345 , C12N2810/6018
摘要： Novel hexon isolated from simian adenovirus serotype 19 encoded in the polynucleotide defined as SEQ ID NO: 3, hepervariable region thereof, chimeric adenovirus comprising the same, and therapeutic use thereof provides a solution to the problem of safety and effective systemic treatment for developing gene therapeutic agents using adenovirus.
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4.发明授权THERAPEUTIC AGENT FOR TREATMENT OF CANCER COMPRISING HUMAN APOLIPOPROTEIN (A) KRINGLES LK68 OR LK8 GENES AS EFFECTIVE INGREDIENT, AND METHOD FOR TREATING CANCER USING THE SAME 有权治疗剂与人载脂蛋白（a）三环LK68或LK8基因治疗癌症的治疗癌症的有效成分，和方法
公开(公告)号：EP1713511B1
公开(公告)日：2011-11-09
申请号：EP05721759.8
申请日：2005-01-10
发明人： LEE, Kyuhyun , YU, Hyunkyung , LEE, Ho-Jeong , AHN, Jin-Hyung , KIM, Jang-Seong , JO, Eui-Cheol , YOON, Yeup , PARK, Doo-Hong , YUN, Seong-Tae
CPC分类号： A61K48/005 , A61K48/00 , C07K14/775 , C12N15/86 , C12N2740/13043 , C12N2750/14143
摘要： The present invention relates to an anticancer or an anti-metastatic agent for gene therapy, more precisely, an anticancer or an anti-metastatic agent for gene therapy containing a gene carrier or cells harboring human apolipoprotein(a) kringle KIV9-KIV10-KV (LK68) or KV (LK8) gene as an effective ingredient, and a treatment method for cancer using the same. The agent for gene therapy of the present invention has an inhibiting effect on the growth and the metastasis of a tumor, so it can be effectively used for the prevention and the treatment of various solid tumors as a metastasis inhibitor or a therapeutic agent for primary tumors.
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5.发明公开HEXON ISOLATED FROM SIMIAN ADENOVIRUS SEROTYPE 19, HYPERVARIABLE REGION THEREOF AND CHIMERIC ADENOVIRUS USING THE SAME 有权AUS AFFEN-ADENOVIRUS SEROTYP 19 ISOLIERTES HEXON，HYPERVARIABLE REGION DAVON UNDCHIMÄRESADENOVIRUS DAMIT
公开(公告)号：EP2558481A1
公开(公告)日：2013-02-20
申请号：EP10849873.4
申请日：2010-04-14
发明人： LEE, Kyuhyun , YUN, Seongtae , KOH, Daekyung , LEE, Hong-Kyu , JO, Eui-Cheol
IPC分类号： C07K14/075 , C12N15/34 , C12N15/861
CPC分类号： C12N7/00 , A61K39/0011 , A61K2039/5256 , C07K14/005 , C12N15/86 , C12N2710/10321 , C12N2710/10322 , C12N2710/10332 , C12N2710/10342 , C12N2710/10343 , C12N2710/10345 , C12N2810/6018
摘要： Novel hexon isolated from simian adenovirus serotype 19 encoded in the polynucleotide defined as SEQ ID NO: 3, hepervariable region thereof, chimeric adenovirus comprising the same, and therapeutic use thereof provides a solution to the problem of safety and effective systemic treatment for developing gene therapeutic agents using adenovirus.
摘要翻译： 从定义为SEQ ID NO：3的多核苷酸中编码的猿猴腺病毒血清型19分离的新型六邻体，其全变体区，包含其的嵌合腺病毒及其治疗用途提供了用于开发基因治疗的安全性和有效全身治疗问题的解决方案 使用腺病毒的药剂。
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