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    Integrated fluid delivery and analysis system
    2.
    发明公开
    Integrated fluid delivery and analysis system 有权
    集成的流体输送和分析系统

    公开(公告)号：EP1231472A1

    公开(公告)日：2002-08-14

    申请号：EP02250913.7

    申请日：2002-02-11

    申请人： Molecular Devices Corporation

    发明人： Giebeler, Robert H. ,  Humphries, Gillian M. ,  Ogle, David G. ,  Hafeman, Dean G. ,  Kaye, Roger A. ,  Modlin, Douglas N. ,  McNerney, Steven A.

    IPC分类号： G01N35/00

    CPC分类号： G01N21/253 ,  G01N35/028 ,  G01N35/1065 ,  G01N35/109 ,  G01N2035/00326 ,  G01N2035/00356 ,  G01N2035/00455 ,  G01N2035/0498 ,  G01N2035/103

    摘要： An integrated fluid delivery and analysis system and components thereof for preparing and/or analyzing samples. The components may include a transport module, a fluidics module, and an analysis module, among others. The system comprises a detection device (1201) configured to detect light from a sample at an examination site, a sample delivery axis extending substantially vertically from the examination site (1604); and at least one material exchange station (1600) along the sample delivery axis above the examination site. Typically, there are: a fluidics head assembly including a dispensing device; a drive mechanism connected to the head assembly for moving the head assembly along a substantially vertical sample delivery axis; and at least two material exchange stations (1600,1602) located along the sample delivery axis, the head assembly being moveable to each material exchange station (1600,1602) to pick up or deposit materials used to conduct an assay.

    摘要翻译： 用于制备和/或分析样品的集成流体输送和分析系统及其部件。 这些组件可以包括运送模块，流控模块和分析模块等。 该系统包括检测装置（1201），检测装置（1201）被配置为检测来自检查部位处的样本的光线，样本递送轴线从检查部位（1604）基本竖直地延伸; 和沿检查部位上方的样本输送轴线的至少一个材料交换站（1600）。 典型地，存在：包括分配装置的流控头组件; 驱动机构，连接到所述头部组件，用于沿着基本竖直的样本传送轴线移动所述头部组件; 和至少两个沿着样本输送轴线定位的材料交换站（1600,1602），头部组件可移动到每个材料交换站（1600,1602）以拾取或沉积用于进行测定的材料。

    Improved single source multi-site photometric measurement system
    5.
    发明公开
    Improved single source multi-site photometric measurement system 失效
    改进的单源多光谱测量系统

    公开(公告)号：EP0217632A3

    公开(公告)日：1989-06-07

    申请号：EP86307346.6

    申请日：1986-09-24

    申请人： Molecular Devices Corporation

    发明人： Chow, Calvin Y.H. ,  Lacy, Michael M. ,  Humphries, Gillian M. ,  Parce, John Wallace ,  Kung, Viola T.

    IPC分类号： G01N21/25

    CPC分类号： G01N21/253 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00621 ,  B01J2219/00659 ,  B01J2219/00702 ,  G01N2201/0438 ,  G01N2201/08

    摘要： A multibeam photometric measuring device includes a light assembly (12) comprising a single modulated light source along with a filter assembly (19) for passing only a desired band of wavelengths and an optical system for suitably focusing light from the light source. A fiber rotor arrangement (24) is provided for sequentially connecting the collimated light source to each of the plurality of fibers (34) disposed in a distributor (32). Light passing through the wells of the sample plate (40) is captured by discrete photodetector cells (44) disposed on a one-to-one correspondence opposite the wells of the plate. A reference fiber links (52) light from the light source to a separate photodetector (45) to provide a reference light signal with which the sensed photodetector signals are compared. The sensed signals are suitably multiplexed and processed by circuitry which allows control over the accuracy with which the signals are processed on the basis of their instantaneous strengths as well as reference readings taken during system initialization. Enhancement of colour distribution resulting from chromogenic reactions is provided by automatic agitation by mechanism (54) of the reacting agents within the sample wells before a reading is taken at each of the sampling intervals of a kinetic measurement sequence.

    Improved single source multi-site photometric measurement system
    6.
    发明公开
    Improved single source multi-site photometric measurement system 失效
    改进的单光源多地点光度测量系统

    公开(公告)号：EP0217632A2

    公开(公告)日：1987-04-08

    申请号：EP86307346.6

    申请日：1986-09-24

    申请人： Molecular Devices Corporation

    发明人： Chow, Calvin Y.H. ,  Lacy, Michael M. ,  Humphries, Gillian M. ,  Parce, John Wallace ,  Kung, Viola T.

    IPC分类号： G01N21/25

    CPC分类号： G01N21/253 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00621 ,  B01J2219/00659 ,  B01J2219/00702 ,  G01N2201/0438 ,  G01N2201/08

    摘要： A multibeam photometric measuring device includes a light assembly (12) comprising a single modulated light source along with a filter assembly (19) for passing only a desired band of wavelengths and an optical system for suitably focusing light from the light source. A fiber rotor arrangement (24) is provided for sequentially connecting the collimated light source to each of the plurality of fibers (34) disposed in a distributor (32).
    Light passing through the wells of the sample plate (40) is captured by discrete photodetector cells (44) disposed on a one-to-one correspondence opposite the wells of the plate. A reference fiber links (52) light from the light source to a separate photodetector (45) to provide a reference light signal with which the sensed photodetector signals are compared. The sensed signals are suitably multiplexed and processed by circuitry which allows control over the accuracy with which the signals are processed on the basis of their instantaneous strengths as well as reference readings taken during system initialization.
    Enhancement of colour distribution resulting from chromogenic reactions is provided by automatic agitation by mechanism (54) of the reacting agents within the sample wells before a reading is taken at each of the sampling intervals of a kinetic measurement sequence.

    摘要翻译： 一种多光束测光测量装置包括：包括单个调制光源的光组件（12），以及仅用于通过所需波长带的滤波器组件（19）以及用于适当地聚焦来自光源的光的光学系统。 提供光纤转子装置（24）用于顺序地将准直光源连接到布置在分配器（32）中的多根光纤（34）中的每一根。 穿过样品板（40）的孔的光由分立的光电检测器单元（44）捕获，所述单独的光电检测器单元（44）与板的孔相对地一一对应地设置。 参考光纤将来自光源的光链接（52）到单独的光电检测器（45），以提供参考光信号，与所检测的光电检测器信号进行比较。 所感测的信号被适当地多路复用并由电路处理，该电路允许基于其瞬时强度以及在系统初始化期间获取的参考读数来控制处理信号的准确度。 在动力学测量序列的每个采样间隔进行读数之前，通过机构（54）对样品孔内的反应试剂的自动搅动来提供由显色反应导致的颜色分布的增强。