公开(公告)号：EP3307258A1

公开(公告)日：2018-04-18

申请号：EP16729240.8

申请日：2016-06-09

申请人： Monash University ,  The Walter and Eliza Hall Institute of Medical Research

发明人： VOSS, Anne Kathrin ,  BAELL, Jonathan ,  NGUYEN, Huu Nghi ,  LEAVER, David J. ,  CLEARY, Benjamin L. ,  LAGIAKOS, H. Rachel ,  SHEIKH, Bilal Nadeem ,  THOMAS, Timothy John

IPC分类号： A61K31/145 ,  A61K31/341 ,  A61K31/38 ,  A61K31/395 ,  C07D213/87 ,  C07D231/12 ,  C07D231/16 ,  C07D333/24 ,  C07C311/49 ,  C07D237/08 ,  C07D249/06 ,  C07D271/06 ,  C07D271/10 ,  C07D277/30 ,  C07D213/54 ,  C07D307/54 ,  A61P35/02

CPC分类号： C07C311/49 ,  A61P35/00 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/16 ,  C07C2602/10 ,  C07D213/56 ,  C07D213/86 ,  C07D213/87 ,  C07D231/12 ,  C07D231/16 ,  C07D237/08 ,  C07D239/26 ,  C07D249/06 ,  C07D271/06 ,  C07D271/10 ,  C07D277/30 ,  C07D307/54 ,  C07D333/24

摘要： where X1 is either CRF2 or N, where RF2 is H or F; X2 is either CR3 or N, where R3 is selected from H, Me, Cl, F OMe; X3 is either CH or N; X4 is either CRF3 or N, where RF3 is H or F; where only one or two of X1, X2, X3 and X4 may be N; and R4 is selected from I, optionally substituted phenyl, optionally substituted C5-6 heteroaryl; optionally substituted C1-6 alkyl and optionally substituted C1-6 alkoxy, which are useful in the treatment of a condition ameliorated by the inhibition of MOZ.