公开(公告)号：EP2167034A1

公开(公告)日：2010-03-31

申请号：EP08755971.2

申请日：2008-05-20

申请人： MonoSol RX LLC

发明人： SANGHVI, Pradeep ,  FUISZ, Richard, C.

IPC分类号： A61K9/00

CPC分类号： A61K31/465 ,  A61K9/006 ,  A61K9/1617 ,  A61K9/1623 ,  A61K9/1635 ,  A61K9/1652 ,  A61K9/1664 ,  A61K9/7007

摘要： Compositions are provided that include water soluble or water dispersible film shreds, a carrier and an active, such as, but not limited to a drug, flavoring agent or coloring agent. Also provided are methods of use of the film shreds, such as in improving the dissolution, stability, aesthetics, or taste of a composition or its components, and in reducing a disease risk associated with an active.

公开(公告)号：EP1986601A2

公开(公告)日：2008-11-05

申请号：EP07716742.7

申请日：2007-01-19

申请人： MonoSol RX LLC

发明人： SANGHVI, Pradeep ,  MYERS, Garry, L. ,  FUISZ, Joseph, M. ,  FUISZ, Richard, C.

IPC分类号： A61K9/00 ,  A61K9/70 ,  B65D65/46 ,  B65D85/808

CPC分类号： A61K9/009 ,  A23G3/56 ,  A23P10/30 ,  A24B13/00 ,  A61K9/0056 ,  A61K9/7007 ,  B65D65/46 ,  B65D85/808

摘要： The present invention relates to packaging in the form of a pouch, which may contain active substances, such as food products, pharmaceutical agents, nutraceuticals and cosmetic agents, or the like. More specifically, in some embodiments, the present invention provides a pouch, which includes at least one porous substrate encompassing a closed volume and at least one water-soluble film at least partially covering the at least one porous substrate. The pouch may contain an active substance within the closed volume, as well as an active substance in the water-soluble film. The present invention also relates to methods of making and using the pouches.

公开(公告)号：EP2509631A1

公开(公告)日：2012-10-17

申请号：EP10836740.0

申请日：2010-12-10

申请人： MonoSol RX LLC

发明人： SCHOBEL, A. Mark ,  DAVIDSON, Kevin ,  MILOSHOFF, Laura ,  SANGHVI, Pradeep ,  HARIHARAN, Madhu

IPC分类号： A61K47/06 ,  A61K9/14

CPC分类号： A61K9/006 ,  A61K9/7007

摘要： The present invention relates to an edible film dosage form that includes a film- forming polymer and a coated active composition capable of taste -masking an active contained therein. An edible film that includes an edible, water-soluble film forming polymer and an active with at least two coating layers is also disclosed.

公开(公告)号：EP3326612A1

公开(公告)日：2018-05-30

申请号：EP18150094.3

申请日：2010-08-05

申请人： MonoSol RX LLC

发明人： MYERS, Gary L. ,  HILBERT, Samuel, D. ,  BOONE, Bill, J. ,  BOGUE, B., Arlie ,  SANGHVI, Pradeep ,  HARIHARAN, Madhusudan

IPC分类号： A61K9/00 ,  A61K31/485 ,  A61K47/10 ,  A61K47/12 ,  A61K9/70

CPC分类号： A61K9/006 ,  A61K9/0056 ,  A61K9/7007 ,  A61K31/485 ,  A61K47/10 ,  A61K47/12

摘要： The present invention relates to products and methods for treatment of various symptoms in a patient, including treatment of pain suffered by a patient. The invention more particularly relates to self-supporting dosage forms which provide an active agent while providing sufficient buccal adhesion of the dosage form. Further, the present invention provides a dosage form which is useful in reducing the likelihood of diversion abuse of the active agent.

公开(公告)号：EP2035290B1

公开(公告)日：2011-03-09

申请号：EP07796593.7

申请日：2007-06-29

申请人： MonoSol RX LLC

发明人： FUISZ, Richard, C. ,  DETWILER, Bruce, D. ,  MYERS, Garry, L. ,  SANGHVI, Pradeep ,  HARIHARAN, Madhusudan ,  MOSS, Laura

IPC分类号： B65D33/00 ,  B65D75/58 ,  B65D83/08 ,  A61F15/00

CPC分类号： G07F11/045 ,  B65D75/5805 ,  B65D83/0847 ,  B65D2215/02

摘要： The packet dispenser (20) includes a container structure (22) having an interior cavity (32). The cavity has a sufficient dimension such that a packet structure (48) may be stored therein. The container structure (22) has an opening (34) to the cavity (32) through which the packet structure (48) can be removed therefrom. A tear structure (40) is connected to the container structure (22) such that the packet structure (48) may contact the tear structure (40) to tear a portion thereof when the packet structure (48) is removed from the cavity (32).

公开(公告)号：EP2035290A2

公开(公告)日：2009-03-18

申请号：EP07796593.7

申请日：2007-06-29

申请人： MonoSol RX LLC

发明人： FUISZ, Richard, C. ,  DETWILER, Bruce, D. ,  MYERS, Garry, L. ,  SANGHVI, Pradeep ,  HARIHARAN, Madhusudan ,  MOSS, Laura

IPC分类号： B65D33/00 ,  B65D75/58 ,  B65D83/08 ,  A61F15/00

CPC分类号： G07F11/045 ,  B65D75/5805 ,  B65D83/0847 ,  B65D2215/02

摘要： The packet dispenser (20) includes a container structure (22) having an interior cavity (32). The cavity has a sufficient dimension such that a packet structure (48) may be stored therein. The container structure (22) has an opening (34) to the cavity (32) through which the packet structure (48) can be removed therefrom. A tear structure (40) is connected to the container structure (22) such that the packet structure (48) may contact the tear structure (40) to tear a portion thereof when the packet structure (48) is removed from the cavity (32).

公开(公告)号：EP1968558B1

公开(公告)日：2016-12-28

申请号：EP06845545.0

申请日：2006-12-14

申请人： MonoSol Rx, LLC

发明人： MYERS, Garry, L. ,  SANGHVI, Pradeep

IPC分类号： A61K9/70

CPC分类号： A61K9/7007 ,  A61K9/006

公开(公告)号：EP2461796A2

公开(公告)日：2012-06-13

申请号：EP10740494.9

申请日：2010-08-05

申请人： MonoSol RX LLC

发明人： MYERS, Garry, L. ,  HILBERT, Samuel, D. ,  BOONE, Bill, J. ,  BOGUE, B., Arlie ,  SANGHVI, Pradeep ,  HARIHARAN, Madhusudan

IPC分类号： A61K9/00 ,  A61K31/485

CPC分类号： A61K9/006 ,  A61K9/0056 ,  A61K9/7007 ,  A61K31/485 ,  A61K47/10 ,  A61K47/12

摘要： The present invention relates to products and methods for treatment of various symptoms in a patient, including treatment of pain suffered by a patient. The invention more particularly relates to self-supporting dosage forms which provide an active agent while providing sufficient buccal adhesion of the dosage form. Further, the present invention provides a dosage form which is useful in reducing the likelihood of diversion abuse of the active agent.

公开(公告)号：EP2315660A1

公开(公告)日：2011-05-04

申请号：EP09808712.5

申请日：2009-08-18

申请人： MonoSol RX LLC

发明人： MYERS, Garry ,  HARIHARAN, Madhusudan ,  SANGHVI, Pradeep ,  SZOPINSKI, Alex ,  DAILEY, Patrick

IPC分类号： B32B1/00

CPC分类号： A61K9/7007 ,  A23P30/00 ,  A61K31/485

摘要： The present invention relates to a method of making a film composition with an improved uniformity of active composition The invention includes a method including the steps of forming a flowable film composition comprising an edible water-soluble polymer, a polar solvent and a particulate active suspended therein, where the ratio of solids to liquids is at least about 95 to about 5 and where the composition compπses a mixture having compositional uniformity per unit volume, directing the flowable film composition to a transfer trough, the transfer trough including a first rotating roller and a movable transfer substrate upon which to form the film, and maintaining uniformity of the flowable film composition dunng the residence time in the trough by maintaining the rate of composition enteπng the transfer trough and the level of the flowable film composition in the transfer trough at a substantially constant level

公开(公告)号：EP2077824A2

公开(公告)日：2009-07-15

申请号：EP07839098.6

申请日：2007-09-28

申请人： MonoSol RX LLC

发明人： SANGHVI, Pradeep ,  FUISZ, Richard, C.

IPC分类号： A61K9/24

CPC分类号： A61K9/009 ,  A61K9/006

摘要： The present invention relates to packaging in the form of a pouch, which may contain active substances, such as food products, pharmaceutical agents, nutraceuticals and cosmetic agents, or the like. More specifically, in some embodiments, the present invention provides a pouch, which includes at least one porous substrate encompassing a closed volume and at least one water-soluble film at least partially embedded in the at least one porous substrate. The pouch may contain an active substance within the closed volume, as well as an active substance in the water-soluble film. The present invention also relates to methods of making and using the pouches.