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1.发明公开PRODUCTS COMPRISING AN EXTRACELLULAR MATRIX TISSUE MATERIAL AND OSTEOGENIC PROTEIN 审中-公开与细胞外基质和成骨蛋白织物材料产品
公开(公告)号：EP3041483A1
公开(公告)日：2016-07-13
申请号：EP14839440.6
申请日：2014-09-02
申请人： Muffin Incorporated
发明人： WALLACE, Shelley L. , TAYLOR, Amanda F. , CHARLEBOIS, Steven , STEINHART, Christine M. , FEARNOT, Neal E.
CPC分类号： A61L27/3633 , A61L27/12 , A61L27/54 , A61L2300/414 , A61L2400/06 , A61L2430/02
摘要： Osteogenic compositions include a decellularized extracellular matrix tissue and bone morphogenic protein, preferably BMP-2. The compositions make beneficial use of the BMP, which can be used at relatively low doses and can bind to native components (e.g., native sulfated glycosaminoglycans such as heparin and/or heparan sulfate) remaining in the decellularized extracellular matrix tissue. Methods for preparation and use of such compositions are also described. The compositions and related methods can be used in the treatment of diseased or damaged bone tissue.
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公开(公告)号：EP3041485B1
公开(公告)日：2020-06-03
申请号：EP14840445.2
申请日：2014-08-29
申请人： Muffin Incorporated
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3.发明公开CELL-SEEDED COMPOSITIONS AND METHODS USEFUL FOR TREATING BONE REGIONS 审中-公开ZELLBESIEDELTE ZUSAMMENSETZUNGEN UND VERFAHREN ZUR BEHANDLUNG VON KNOCHENREGIONEN
公开(公告)号：EP3041485A1
公开(公告)日：2016-07-13
申请号：EP14840445.2
申请日：2014-08-29
申请人： Muffin Incorporated
发明人： WALLACE, Shelley L. , TAYLOR, Amanda F. , CHARLEBOIS, Steven , STEINHART, Christine M. , FEARNOT, Neal E.
摘要： Compositions and methods for treating diseased or damaged bone, preferably ischemic and/or necrotic bone, include the use of a combination of endothelial progenitor cells and mesenchymal stem cells, desirably also in conjunction with a collagenous extracellular matrix tissue. Methods for preparation of such compositions are also described.
摘要翻译： 用于治疗患病或损坏的骨，优选缺血性和/或坏死性骨的组合物和方法包括使用内皮祖细胞和间充质干细胞的组合，期望还与胶原细胞外基质组织结合。 还描述了制备这种组合物的方法。
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