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公开(公告)号：EP3052024B1
公开(公告)日：2018-10-24
申请号：EP14850980.5
申请日：2014-09-30
申请人： Muffin Incorporated
CPC分类号： A61B8/0891 , A61B1/018 , A61B8/12 , A61B8/445 , A61B8/4461
摘要： Disclosed are embodiments of devices and methods for imaging the inside of a body part, such as a blood vessel. In particular embodiments, a catheter has a chamber within which is a transducer. A wire guide channel extends throughout the length of the catheter. The transducer is rotatable around the wire guide channel.
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2.发明公开GUIDE MEMBERS AND ASSOCIATED APPARATUSES USEFUL FOR INTRAVASCULAR ULTRASOUND PROCEDURES 审中-公开LEITERELEMENTE UNDZUGEHÖRIGEVORRICHTUNGENFÜRINTRAVASKULARE ULTRASCHALLVERFAHREN
公开(公告)号：EP3139839A1
公开(公告)日：2017-03-15
申请号：EP15789395.9
申请日：2015-05-05
申请人： Muffin Incorporated
CPC分类号： A61M25/09 , A61B8/0891 , A61B8/12 , A61B8/445 , A61B8/483 , A61M25/0108 , A61M2025/0177 , A61M2025/09133 , A61M2025/09166
摘要： Described are guidewires having at least one echolucent segment, and associated apparatuses and methods. The guidewires can be combined with devices equipped with intravascular ultrasound probes and used to effectively image regions during procedures underway in the vascular environment. The echolucent segment can have one or more echogenic markers to enable detection of the segment and/or relative movement of the segment using intravascular ultrasound.
摘要翻译： 描述了具有至少一个回波段的导线以及相关的装置和方法。 引导线可以与装有血管内超声探头的装置组合，并用于在血管环境中正在进行的手术期间有效地对区域进行成像。 回声部分可以具有一个或多个回声标记，以使得能够使用血管内超声检测片段和/或片段的相对运动。
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3.发明公开CELL-SEEDED COMPOSITIONS AND METHODS USEFUL FOR TREATING BONE REGIONS 审中-公开ZELLBESIEDELTE ZUSAMMENSETZUNGEN UND VERFAHREN ZUR BEHANDLUNG VON KNOCHENREGIONEN
公开(公告)号：EP3041485A1
公开(公告)日：2016-07-13
申请号：EP14840445.2
申请日：2014-08-29
申请人： Muffin Incorporated
发明人： WALLACE, Shelley L. , TAYLOR, Amanda F. , CHARLEBOIS, Steven , STEINHART, Christine M. , FEARNOT, Neal E.
摘要： Compositions and methods for treating diseased or damaged bone, preferably ischemic and/or necrotic bone, include the use of a combination of endothelial progenitor cells and mesenchymal stem cells, desirably also in conjunction with a collagenous extracellular matrix tissue. Methods for preparation of such compositions are also described.
摘要翻译： 用于治疗患病或损坏的骨，优选缺血性和/或坏死性骨的组合物和方法包括使用内皮祖细胞和间充质干细胞的组合，期望还与胶原细胞外基质组织结合。 还描述了制备这种组合物的方法。
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6.发明公开PRODUCTS COMPRISING AN EXTRACELLULAR MATRIX TISSUE MATERIAL AND OSTEOGENIC PROTEIN 审中-公开与细胞外基质和成骨蛋白织物材料产品
公开(公告)号：EP3041483A1
公开(公告)日：2016-07-13
申请号：EP14839440.6
申请日：2014-09-02
申请人： Muffin Incorporated
发明人： WALLACE, Shelley L. , TAYLOR, Amanda F. , CHARLEBOIS, Steven , STEINHART, Christine M. , FEARNOT, Neal E.
CPC分类号： A61L27/3633 , A61L27/12 , A61L27/54 , A61L2300/414 , A61L2400/06 , A61L2430/02
摘要： Osteogenic compositions include a decellularized extracellular matrix tissue and bone morphogenic protein, preferably BMP-2. The compositions make beneficial use of the BMP, which can be used at relatively low doses and can bind to native components (e.g., native sulfated glycosaminoglycans such as heparin and/or heparan sulfate) remaining in the decellularized extracellular matrix tissue. Methods for preparation and use of such compositions are also described. The compositions and related methods can be used in the treatment of diseased or damaged bone tissue.
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公开(公告)号：EP3597254A1
公开(公告)日：2020-01-22
申请号：EP19189191.0
申请日：2013-06-05
申请人： Muffin Incorporated
发明人： FISCHER, Frank J. , RANDOLPH, James, R. , FEARNOT, Neal E. , TAYLOR, Jimmy, L. , SHIRLEY, Gary, Bradford
摘要： Described in one aspect is a multi-pressure monitoring system for cell or other therapy includes a first catheter (570) having a first lumen for accepting a treatment device, a second lumen for inflating a balloon, a pressure sensor (545) for monitoring fluid pressure within the first lumen, and a flow restrictor (115) such as a hemostasis valve for limiting the exchange of fluids into and out of the first lumen while treatment devices are present or exchanged in the first lumen. Also disclosed is a method of using the first catheter with a first pressure monitor coupled to the first pressure sensor (4545) along with a second catheter (525) attached to a second pressure sensor (520) coupled to a second pressure monitor. The second catheter is positioned within the first lumen of the first catheter during treatment operations and the first and second pressure monitors are used to verify proper pressures throughout the procedure. Described also are novel methods, systems, and catheters for delivering flowable therapeutic substances, such as viable cellular preparations, to patients.
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公开(公告)号：EP3193812B1
公开(公告)日：2018-06-27
申请号：EP15760011.5
申请日：2015-08-26
申请人： Muffin Incorporated
发明人： HAVEL, William J. , FEARNOT, Neal E. , MCKINNIS, Peter S. , SISKEN, Richard B. , BAXTER, Charles Leland
CPC分类号： A61J1/1406 , A61J1/10 , A61J1/1468 , A61J1/2093 , B29C65/02 , B29C65/04 , B29C65/08 , B29C65/10 , B29C65/14 , B29C65/16 , B29C65/48 , B29C65/4895 , B29C66/1122 , B29C66/344 , B29C66/3452 , B29C66/43121 , B29C66/71 , B29C66/7212 , B29C66/73921 , B29C66/8266 , B29C66/8322 , B29L2031/7148 , B31B70/00 , B65B51/26 , B65D75/42 , B65D75/44 , B65D75/5883 , B29K2023/083 , B29K2307/04 , B29K2023/06 , B29K2023/12 , B29K2027/06 , B29K2075/00
摘要： Described in one aspect is a multi-cell or multi-chambered container for sealing various materials such as therapeutic or diagnostic agents, animal or human tissue, tissue samples, specimens, blood, genetic material, or any other material. The container includes seals formed by folding the wall of the elongate body transverse to the interior of the elongate body and maintaining the folded wall portions adjacent one another or joining them together. In another aspect, the container disclosed may be made according to a method involving creating multiple seals at various locations along the elongate body thus creating sealed voids or cells between the seals within the elongate body.
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公开(公告)号：EP3193812A1
公开(公告)日：2017-07-26
申请号：EP15760011.5
申请日：2015-08-26
申请人： Muffin Incorporated
发明人： HAVEL, William J. , FEARNOT, Neal E. , MCKINNIS, Peter S. , SISKEN, Richard B. , BAXTER, Charles Leland
CPC分类号： A61J1/1406 , A61J1/10 , A61J1/1468 , A61J1/2093 , B29C65/02 , B29C65/04 , B29C65/08 , B29C65/10 , B29C65/14 , B29C65/16 , B29C65/48 , B29C65/4895 , B29C66/1122 , B29C66/344 , B29C66/3452 , B29C66/43121 , B29C66/71 , B29C66/7212 , B29C66/73921 , B29C66/8266 , B29C66/8322 , B29L2031/7148 , B31B70/00 , B65B51/26 , B65D75/42 , B65D75/44 , B65D75/5883 , B29K2023/083 , B29K2307/04 , B29K2023/06 , B29K2023/12 , B29K2027/06 , B29K2075/00
摘要： Described in one aspect is a multi-cell or multi-chambered container for sealing various materials such as therapeutic or diagnostic agents, animal or human tissue, tissue samples, specimens, blood, genetic material, or any other material. The container includes seals formed by folding the wall of the elongate body transverse to the interior of the elongate body and maintaining the folded wall portions adjacent one another or joining them together. In another aspect, the container disclosed may be made according to a method involving creating multiple seals at various locations along the elongate body thus creating sealed voids or cells between the seals within the elongate body.
摘要翻译： 在一个方面中描述了用于密封各种材料例如治疗剂或诊断剂，动物或人体组织，组织样本，标本，血液，遗传材料或任何其他材料的多室或多室容器。 容器包括通过将细长体的壁横向于细长体的内部折叠而形成的密封件，并将折叠的壁部分彼此相邻或将它们连接在一起。 在另一方面，所公开的容器可以根据涉及在沿着细长主体的不同位置处创建多个密封件从而在细长主体内的密封件之间产生密封的空隙或细胞的方法来制造。
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