公开(公告)号：EP1429789B1

公开(公告)日：2008-05-14

申请号：EP02800120.4

申请日：2002-09-25

申请人： N.V. Nutricia

发明人： STAHL, Bernd ,  FINKE, Berndt ,  SCHMITT, Joachim ,  GOEBEL, Werner ,  SLAGHUIS, Jörg

IPC分类号： A61K31/702 ,  A61K31/715 ,  A61P31/00

CPC分类号： A61K31/702 ,  A61K31/715

摘要： The invention relates to the use of neutral straight-chain or branched oligosaccharides for preventing the invasion and infection of mammal cells by pathogens and for fighting diseases caused by such pathogens. The invention also relates to food, dietetic products and pharmaceutical agents containing said oligosaccharides. Said oligosaccharides consist of a base unit of general formula (I), and between 0 and 19 other units of general formula (II), which are linked directly or indirectly to the base unit. In said formulae, Gal represents a galactose monosaccharide unit; Glc represents a glucose monosaccharide unit; HexNAc represents an N-acetylated galactosamine or glucosamine monosaccharide unit (GalNAc or GlcNAc); the radicals R independently represent a beta 1-3 or beta 1-6 glycosidic link to the HexNAc monosaccharide unit of the next [Gal-HexNAc] unit of general formula (II), and on a terminal [Gal-HexNAc] unit, a deoxyhexose radical which is linked to the galactose monosaccharide unit of said terminal [Gal-HexNAc] unit, or said radicals R are not present; and a terminal [Gal-HexNAc] unit, wherein the radical(s) R represent a deoxyhexose radical, can have another deoxyhexose radical on the HexNAc monosaccharide unit.

公开(公告)号：EP1242436B1

公开(公告)日：2004-11-17

申请号：EP00983244.5

申请日：2000-12-07

申请人： N.V. Nutricia

发明人： STAHL, Bernd ,  BÖHM, Günther ,  FINKE, Berndt ,  GEORGI, Gilda ,  JELINEK, Jürgen ,  SCHMITT, Joachim, J.

IPC分类号： C07H3/06

CPC分类号： A61K45/06 ,  A23L5/00 ,  A23L29/30 ,  A23L33/10 ,  A23L33/125 ,  A23V2002/00 ,  A61K31/702 ,  A61K35/20 ,  A61K2300/00 ,  A23V2250/28

摘要： The invention relates to an oligosaccharide mixture based on oligosaccharides produced from one or several animal milks and which are composed of two or more monosaccharide units. Said oligosaccharide mixture is characterized in that it comprises at least two oligosaccharide fractions which are each composed of at least two different oligosaccharides. The invention is further cahracterized in that lactose does not pertain thereto and the total spectrum of the oligosaccharides present in the oligosaccharide mixture differs from those present in animal milk or animal milks, wherefrom the oligosaccharide fractions are extracted and that a) if said oligosaccharides are extracted from only one animal milk, the proportion of neutral oligosaccharides to acidic oligosaccharides is 90 -60: 10 - 40 weight %, or b) if said oligosaccharides are extracted from at least two animal milks, the oligosaccharides extracted from two different animal milks each make up 10 weight % of the total amount of oligosaccharides present in the oligosaccharide mixture. The oligosaccharide mixture according to the invention approximates to human milk with respect to its positive properties and in particular its anti-infective activity.

公开(公告)号：EP1470142A2

公开(公告)日：2004-10-27

申请号：EP03734720.0

申请日：2003-01-31

申请人： N.V. Nutricia

发明人： STAHL, Bernd ,  KELM, Sörge ,  BOEHM, Günther ,  FINKE, Berndt ,  SLAGHIUS, Jörg

IPC分类号： C07H7/027 ,  C07H17/04 ,  A61K31/702 ,  A61P37/00 ,  A23L1/09

CPC分类号： C07H17/04 ,  A23C9/20 ,  A23F3/30 ,  A23L29/30 ,  A23L33/125 ,  A23L33/40 ,  A23V2002/00 ,  A23V2250/5438 ,  C07H7/027 ,  A23V2250/156 ,  A23V2250/70 ,  A23V2250/0644

摘要： The invention relates to the use of sialic carbohydrates of general formula (I), containing at least one carbohydrate unit of general formula (II) for the immune modulation, immune suppression and in the prevention and treatment of infections in humans and animals. In said formula (II), Sia represents a sialic acid or a sialic acid derivative in an α2-3 bond, Gal represents a galactose-monosaccharide-unit, HexNac represents an N-acetylated galactosamine or glucosamine-monosaccharide-unit (GalNAc or G1cNAc), Hex represents a galactose- or glucose-monosaccharide-unit (Ga1 or G1c), C represents HexNac or Hex or is absent, n represents 1 - 50, V represents OH, a carbohydrate radical or a connecting point on a support T, with the proviso that if V represents OH, n represents 1, and if V represents a carbohydrate radical or a support T, n represents the number of carbohydrate unites of general formula (II) directly connected to said carbohydrate radical or support, X represents a sialic acid or a sialic acid derivative, wherein a second sialic acid or a sialic acid derivative or more sialic acid or sialic acid derivatives can be connected to an α2-8 bond, a phosphate, a sulphate, or carboxyl-group or a monosaccharide having a phosphate, sulphate, or carboxyl group and only one of the radicals X is present.

公开(公告)号：EP1429789A2

公开(公告)日：2004-06-23

申请号：EP02800120.4

申请日：2002-09-25

申请人： N.V. Nutricia

发明人： STAHL, Bernd ,  FINKE, Berndt ,  SCHMITT, Joachim ,  GOEBEL, Werner ,  SLAGHUIS, Jörg

IPC分类号： A61K31/702 ,  A61K31/715 ,  A61P31/00

CPC分类号： A61K31/702 ,  A61K31/715

摘要： The invention relates to the use of neutral straight-chain or branched oligosaccharides for preventing the invasion and infection of mammal cells by pathogens and for fighting diseases caused by such pathogens. The invention also relates to food, dietetic products and pharmaceutical agents containing said oligosaccharides. Said oligosaccharides consist of a base unit of general formula (I), and between 0 and 19 other units of general formula (II), which are linked directly or indirectly to the base unit. In said formulae, Gal represents a galactose monosaccharide unit; Glc represents a glucose monosaccharide unit; HexNAc represents an N-acetylated galactosamine or glucosamine monosaccharide unit (GalNAc or GlcNAc); the radicals R independently represent a β 1-3 or β 1-6 glycosidic link to the HexNAc monosaccharide unit of the next [Gal-HexNAc] unit of general formula (II), and on a terminal [Gal-HexNAc] unit, a deoxyhexose radical which is linked to the galactose monosaccharide unit of said terminal [Gal-HexNAc] unit, or said radicals R are not present; and a terminal [Gal-HexNAc] unit, wherein the radical(s) R represent a deoxyhexose radical, can have another deoxyhexose radical on the HexNAc monosaccharide unit.

公开(公告)号：EP1469866B1

公开(公告)日：2009-05-13

申请号：EP03706365.8

申请日：2003-01-20

申请人： N.V. Nutricia

发明人： STAHL, Bernd ,  FINKE, Berndt ,  SCHMITT, Joachim ,  GOEBEL, Werner ,  SLAGHIUS, Jörg ,  BOEHM, Günther

IPC分类号： A61K31/715 ,  A61P31/04

CPC分类号： A61K31/715

摘要： The use of, in particular homopolymeric, cycloglycans with an annular base structure of 2 to 40 monosaccharides in the ring for the prevention of the invasion and infection of mammalian cells by pathogens. The treatment of diseases caused by said pathogens and foodstuffs and dietetic and pharmaceutical products comprising said cycloglycans.

公开(公告)号：EP1469866A1

公开(公告)日：2004-10-27

申请号：EP03706365.8

申请日：2003-01-20

申请人： N.V. Nutricia

发明人： STAHL, Bernd ,  FINKE, Berndt ,  SCHMITT, Joachim ,  GOEBEL, Werner ,  SLAGHIUS, Jörg ,  BOEHM, Günther

IPC分类号： A61K31/715

CPC分类号： A61K31/715

摘要： The use of, in particular homopolymeric, cycloglycans with an annular base structure of 2 to 40 monosaccharides in the ring for the prevention of the invasion and infection of mammalian cells by pathogens. The treatment of diseases caused by said pathogens and foodstuffs and dietetic and pharmaceutical products comprising said cycloglycans.

公开(公告)号：EP1242436A2

公开(公告)日：2002-09-25

申请号：EP00983244.5

申请日：2000-12-07

申请人： N.V. Nutricia

发明人： STAHL, Bernd ,  BÖHM, Günther ,  FINKE, Berndt ,  GEORGI, Gilda ,  JELINEK, Jürgen ,  SCHMITT, Joachim, J.

IPC分类号： C07H3/06

CPC分类号： A61K45/06 ,  A23L5/00 ,  A23L29/30 ,  A23L33/10 ,  A23L33/125 ,  A23V2002/00 ,  A61K31/702 ,  A61K35/20 ,  A61K2300/00 ,  A23V2250/28

摘要： The invention relates to an oligosaccharide mixture based on oligosaccharides produced from one or several animal milks and which are composed of two or more monosaccharide units. Said oligosaccharide mixture is characterized in that it comprises at least two oligosaccharide fractions which are each composed of at least two different oligosaccharides. The invention is further cahracterized in that lactose does not pertain thereto and the total spectrum of the oligosaccharides present in the oligosaccharide mixture differs from those present in animal milk or animal milks, wherefrom the oligosaccharide fractions are extracted and that a) if said oligosaccharides are extracted from only one animal milk, the proportion of neutral oligosaccharides to acidic oligosaccharides is 90 -60: 10 - 40 weight %, or b) if said oligosaccharides are extracted from at least two animal milks, the oligosaccharides extracted from two different animal milks each make up 10 weight % of the total amount of oligosaccharides present in the oligosaccharide mixture. The oligosaccharide mixture according to the invention approximates to human milk with respect to its positive properties and in particular its anti-infective activity.