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公开(公告)号：EP1346981A4
公开(公告)日：2004-03-24
申请号：EP01912138
申请日：2001-03-07
IPC分类号： C07D205/08 , C07D201/08
CPC分类号： C07D201/08 , Y02P20/582
摘要： A process for synthesizing a β-lactam in water at a high temperature under a high pressure; and a process for producing a β-lactam. Namely, a process for synthesizing a ß-lactam characterized by reacting aβ-amino acid in water at a high temperature under a high pressure, wherein the β-lactam is synthesized at a high rate by cyclizing the β-amino acid in water at a high temperature of 200 °C or more under a high pressure of 10 Mpa or more; and a process for producing a β-lactam characterized by synthesizing the β-lactam by reacting a β-amino acid in water at a high temperature under a high pressure and then separating and purifying the β-lactam with the use of a column separating agent.
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公开(公告)号：EP1336603A4
公开(公告)日：2005-11-16
申请号：EP01978942
申请日：2001-10-30
发明人： HATAKEDA KIYOTAKA , IKUSHIMA YUTAKA , SATO OSAMU , KAWANAMI HAJIME , KANAKUBO MITSUHIRO , TORII KAZUO
IPC分类号： C07C227/08 , C07C227/40 , C07C229/08 , C07C229/24 , C07C229/26 , C07D233/64
CPC分类号： C07C227/40 , C07C227/08 , C07C229/08 , C07C229/24 , C07C229/26
摘要： A method of introducing an amino group, characterized by reacting an organic acid with ammonia under high-temperature high-pressure conditions to introduce an amino group into the organic acid; a method of synthesizing an amino acid, characterized by reacting an organic acid with ammonia under high-temperature high-pressure conditions to introduce an amino group into the organic acid and thereby synthesize an amino acid; and a process for producing an amino acid, characterized by reacting an organic acid with ammonia under high-temperature high-pressure conditions to introduce an amino group into the organic acid and thereby synthesize an amino acid, and then purifying and isolating the amino acid with an ion exchange resin.
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公开(公告)号：EP1312611A4
公开(公告)日：2006-12-06
申请号：EP00977971
申请日：2000-11-28
IPC分类号： C07C227/20 , C07K1/12 , A23J3/30 , A23L1/305 , A61K31/195 , C07C227/18 , C07C227/28 , C07C229/00 , C07C229/02 , C07C237/12 , C07C237/22 , C07K14/415 , C07K14/425 , G01N33/68
CPC分类号： C07K1/12 , A23J3/30 , A23L33/175 , A23L33/18 , C07C227/18 , C07C227/28 , Y02P20/544 , C07C229/02
摘要： A method of continuously and quickly degrading a protein into peptides and/or amino acids in supercritical water or high-pressure hot water at around the supercritical point. Namely, a method of continuously and quickly producing peptides and/or amino acids from a protein which comprises using a flow-through type reactor consisting of a substrate-introducing line for supplying a substrate, a pre-heating oven for supplying high-pressure hot water, a reaction oven for heating a liquid reaction mixture and reacting the same and a cooling unit for cooling the liquid reaction mixture, and continuously hydrolyzing the substrate protein supplied into the reaction oven in supercritical water or high-pressure hot water at around the supercritical point under a pressure of 22.05 MPa or above and at a temperature of 375?C or above; and a method of continuously and quickly hydrolyzing a protein by the above-described process. By using this method, it is possible to obtain preparations which are substantially different from the products obtained by the batch method and contaminated with little secondary and tertiary reaction products. Thus, this method is highly useful particularly in, for example, production of physiologically active peptides and pretreatment for the evaluation and analysis of amino acid composition.
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公开(公告)号：EP1369413A4
公开(公告)日：2005-07-20
申请号：EP01914201
申请日：2001-03-23
发明人： HATAKEDA KIYOTAKA , SATO OSAMU , IKUSHIMA YUTAKA , TORII KAZUO
IPC分类号： B01J3/00 , B01J3/02 , C07D201/04 , C07D201/06 , C07D223/10
CPC分类号： C07D201/06 , C07D201/04 , C07D223/10
摘要： A process for continuously producing a lactam in water at a high temperature under a high pressure. Namely, a process for producing a lactam characterized by selectively synthesizing the lactam without causing hydrolysis by introducing an oxime into flowing water at a high temperature under a high pressure, wherein the lactam is continuously synthesized at a high rate from the oxime in water at a high temperature of 250 °C or more under a high pressure of 12 Mpa or more.
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