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公开(公告)号：EP0918547A2
公开(公告)日：1999-06-02
申请号：EP97938031.0
申请日：1997-07-24
CPC分类号： C07K7/06 , A61K47/54 , A61K47/547 , A61K47/549 , A61K51/087 , A61K51/088 , A61K2123/00 , C07K1/13 , C07K14/4721
摘要： Radiolabeled annexin and modified annexin conjugates useful for imaging vascular thrombi are described. Methods for making and using such radiolabeled annexin conjugates are also provided.
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公开(公告)号：EP0918547B1
公开(公告)日：2004-03-10
申请号：EP97938031.8
申请日：1997-07-24
CPC分类号： C07K7/06 , A61K47/54 , A61K47/547 , A61K47/549 , A61K51/087 , A61K51/088 , A61K2123/00 , C07K1/13 , C07K14/4721
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公开(公告)号：EP0906015A1
公开(公告)日：1999-04-07
申请号：EP97926844.0
申请日：1997-06-06
申请人： NEORX CORPORATION
发明人： THEODORE, Louis, J. , AXWORTHY, Donald, B. , RENO, John, M. , YAU, Eric, K. , GUSTAVSON, Linda, M. , FRITZBERG, Alan, R.
IPC分类号： A61K47
CPC分类号： B82Y5/00 , A61K47/6893
摘要： Liver retention clearing agents (LRCAs) and the use thereof are discussed. LRCAs are composed of a hepatic clearance directing component which directs the biodistribution of a LRCA-containing construct to hepatic clearance; a binding component which mediates binding of the LRCA to a compound for which rapid hepatic clearance is desired; a liver retention component which diminishes access of binding component-containing metabolites to target sites; and a structural component to provide a scaffold for the other components.
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4.发明公开CLEAVABLE LINKERS FOR THE REDUCTION OF NON-TARGET ORGAN RETENTION OF IMMUNOCONJUGATES 失效FISSILE留下来减少非靶器官的积累免疫。
公开(公告)号：EP0436664A1
公开(公告)日：1991-07-17
申请号：EP89912052.0
申请日：1989-09-29
申请人： NEORX CORPORATION
发明人： ABRAMS, Paul, G. , RENO, John, M. , FRITZBERG, Alan, R. , SRINIVASAN, Ananthachari , ANDERSON, David, C.
CPC分类号： A61K51/1093 , A61K47/65 , A61K51/088 , A61K2121/00 , A61K2123/00
摘要： Un procédé permettant la réduction de l'accumulation par des organes non ciblés d'immunoconjugués administrés in vivo au cours d'actes thérapeutiques ou diagnostiques, consiste à utiliser des immunoconjugués comprenant des éléments de liaison clivables au niveau des organes non ciblés. Lesdits éléments de liaison sont clivables dans des des conditions existantes, ou induites, au niveau d'un ou de plusieurs organes non ciblés, entre autres les reins et le foie.
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公开(公告)号：EP0342215A1
公开(公告)日：1989-11-23
申请号：EP88909689.0
申请日：1988-09-26
申请人： GENENTECH, INC. , NEORX CORPORATION
IPC分类号： A61K51
CPC分类号： A61K51/088 , A61K51/08 , A61K2121/00 , A61K2123/00 , Y10S930/28
摘要： A fibrin-binding protein such as t-PA is labeled with a de tectable substance, such as a radionuclide, and administered to a patient for diagnosis of blood clots and for monitoring the dissolution thereof during therapy. The detectable substance preferablfy is attached to t-PA through linkers which specifically bind to the portion of the t-PA protein responsible for enzymat ic activity, thereby diminishing this activity while leaving the fi brin-binding property of the protein intact.
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6.发明授权HUMANIZED ANTIBODIES THAT BIND TO THE SAME ANTIGEN AS BOUND BY ANTIBODY NR-LU-13, AND THEIR USE IN PRETARGETING METHODS 失效人源化抗体的相同抗原的抗体NR-LU-13的结合和它们在“预靶向” METHOD
公开(公告)号：EP0909277B1
公开(公告)日：2003-08-27
申请号：EP97931103.2
申请日：1997-06-06
申请人： NEORX CORPORATION
发明人： GRAVES, Scott, S. , RENO, John, M. , MALLET, Robert, W. , HYLARIDES, Mark, D. , SEARLE, Stephen M.J. , HENRY, Andrew, H. , PEDERSEN, Jan, T. , REES, Anthony, R.
IPC分类号： C07K16/30 , C07K16/46 , C07K1/113 , C12N5/10 , A61K47/48 , A61K39/395 , G01N33/574 , G01N33/577
CPC分类号： B82Y5/00 , A61K38/00 , A61K47/68 , A61K47/6898 , A61K2039/505 , C07K1/1133 , C07K16/00 , C07K16/30 , C07K2317/24 , C07K2317/41 , C07K2317/732 , C07K2317/734 , C07K2319/00
摘要： Humanized antibodies which bind the NR-LU-13 antigen, conjugates containing such antibodies, and their use in pretargeting methods and conventional antibody therapy and immunodiagnosis are provided.
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公开(公告)号：EP1190061A1
公开(公告)日：2002-03-27
申请号：EP00941246.1
申请日：2000-06-05
申请人： NEORX CORPORATION
发明人： GOSHORN, Stephen, Charles , GRAVES, Scott, Stoll , SCHULTZ, Joanne, Elaine , LIN, Yukang , SANDERSON, James, Allen , RENO, John, M.
IPC分类号： C12N15/31 , C12N15/13 , C12N15/62 , C12N15/72 , C12N1/21 , C07K14/36 , C07K16/28 , A61K39/395 , A61K47/48
CPC分类号： B82Y5/00 , A61K39/00 , A61K47/665 , C07K14/36 , C07K16/2896 , C07K2317/622 , C07K2319/00 , C07K2319/02 , C07K2319/22
摘要： The present invention provides vectors for expressing genomic streptavidin fusion cassettes. In the various embodiments, fusion proteins produced from these vectors are provided. In particular embodiments, fusion proteins comprising a single chain antibody and genomic streptavidin are provided as are vectors encoding the same. Also provided, are methods of using the fusion proteins of the present invention, and in particular, the use of scFvSA fusion proteins as diagnostic markers or as a cell specific targeting agents.
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公开(公告)号：EP0569531A1
公开(公告)日：1993-11-18
申请号：EP92906121.0
申请日：1992-01-17
申请人： NEORX CORPORATION
发明人： RENO, John, M. , BOTTINO, Becky, J.
CPC分类号： A61K51/10 , A61K38/00 , A61K51/1093 , A61K2123/00 , C07K16/00
摘要： Procédés de préparation de fragments F(ab')2 métaboliquement stables et réticulés de manière covalente de molécules d'anticorps, destinés à être utilisés sous forme marquée comme agents de diagnostic et thérapeutiques in vivo, fragments F(ab')2 stabilisés ainsi produits sous forme libre ou conjuguée à une fraction chimique, matériels contenant lesdits fragments et procédés d'utilisation de ces fragments à des fins de diagnostic ou de thérapie. Selon ledit procédé la réticulation a lieu après réduction des liaisons disulfure à chaîne intermédiaire lourde, mais avant clivage de l'anticorps réticulé afin de produire les molécules de F(ab')2.
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9.发明授权
公开(公告)号：EP0342215B1
公开(公告)日：1993-08-25
申请号：EP88909689.7
申请日：1988-09-26
申请人： GENENTECH, INC. , NEORX CORPORATION
CPC分类号： A61K51/088 , A61K51/08 , A61K2121/00 , A61K2123/00 , Y10S930/28
摘要： A fibrin-binding protein such as t-PA is labeled with a detectable substance, such as a radionuclide, and administered to a patient for diagnosis of blood clots and for monitoring the dissolution thereof during therapy. The detectable substance preferably is attached to t-PA through linkers which specifically bind to the portion of the t-PA protein responsible for enzymatic activity, thereby diminishing this activity while leaving the fibrin-binding property of the protein intact.
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公开(公告)号：EP0646019B9
公开(公告)日：2002-12-18
申请号：EP93915235.1
申请日：1993-06-07
申请人： NEORX CORPORATION
CPC分类号： C07D495/04 , A61K47/54 , A61K47/557 , A61K47/665 , A61K47/68 , A61K47/6887 , A61K47/6893 , A61K47/6898 , A61K51/0497 , A61K51/1268 , A61K2121/00 , A61K2123/00 , B82Y5/00
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