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1.发明公开PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS 有权PYRROLO [2,3-D] PYRIMIDINDERIVATE，VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS KINASE-HEMMER
公开(公告)号：EP2997030A1
公开(公告)日：2016-03-23
申请号：EP14721891.1
申请日：2014-05-07
发明人： ANGIOLINI, Mauro , BUFFA, Laura , MENICHINCHERI, Maria , MOTTO, Ilaria , POLUCCI, Paolo , TRAQUANDI, Gabriella , ZUCCOTTO, Fabio
IPC分类号： C07D487/04
CPC分类号： A61K31/519 , A61K31/496 , A61K45/06 , C07D487/04
摘要： The present invention relates to 6-amino-7-deaza-purine derivatives which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular RET family kinases. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions containing these compounds.
摘要翻译： 本发明涉及调节蛋白激酶活性的6-氨基-7-去氮嘌呤衍生物，因此可用于治疗由失调的蛋白激酶活性引起的疾病，特别是RET家族激酶。 本发明还提供了制备这些化合物的方法，包含这些化合物的药物组合物，以及使用含有这些化合物的药物组合物治疗疾病的方法。
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公开(公告)号：EP1999131B1
公开(公告)日：2013-10-23
申请号：EP07726618.7
申请日：2007-03-02
发明人： BANDIERA, Tiziano , BERTRAND, Jay Aaron , PEVARELLO, Paolo , PERRONE, Ettore , LOMBARDI BORGIA, Andrea , ORRENIUS, Sten Christian , ANGIOLINI, Mauro , FANCELLI, Daniele
IPC分类号： C07D487/04 , A61K31/4162 , A61P35/00
CPC分类号： C07D487/04 , A61K31/4162 , A61K31/496 , A61K31/5377
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3.发明公开SUBSTITUTED PYRIMIDINYLPYRROLOPYRIDINONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS 有权取代PYRIMIDINYLPYRROLOPYRIDINONDERIVATE，工艺及其使用AS激酶抑制剂和及其
公开(公告)号：EP2443117A1
公开(公告)日：2012-04-25
申请号：EP10725144.9
申请日：2010-06-11
发明人： MARCHIONNI, Chiara , ZUCCOTTO, Fabio , BADARI, Alessandra , ANGIOLINI, Mauro , CARENZI, Davide , CALDARELLI, Marina , PULICI, Maurizio
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04 , A61K31/506 , A61K45/06 , A61N5/00
摘要： Pyrimidinylpyrrolopyridinone derivatives of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
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公开(公告)号：EP2303891A1
公开(公告)日：2011-04-06
申请号：EP09769164.6
申请日：2009-06-17
发明人： CALDARELLI, Marina , ANGIOLINI, Mauro , COLOMBO, Riccardo , DISINGRINI, Teresa , NUVOLONI, Stefano , POSTERI, Helena , SALSA, Matteo , SILVAGNI, Marco
IPC分类号： C07D487/04 , A61K31/517 , A61P35/00
CPC分类号： C07D487/04 , A61K31/519 , C07D239/70
摘要： The present invention relates to pyrazolo-quinazolines, characterized by an ortho-substituted-arylamino, heterocyclylamino- or C
3 -C
7 cycloalkylamino residue at 8 position and an aryl, heterocyclyl or C
3 -C
7 cycloalkyl as substituent of a carboxamide at 3 position of the molecula framework. The compounds of this invention modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular MPS1/TTK. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.-
公开(公告)号：EP2917214B1
公开(公告)日：2019-08-28
申请号：EP13783956.9
申请日：2013-10-31
发明人： MENICHINCHERI, Maria , ANGIOLINI, Mauro , BERTRAND, Jay Aaron , CARUSO, Michele , POLUCCI, Paolo , QUARTIERI, Francesca , SALOM, Barbara , SALSA, Matteo , ZUCCOTTO, Fabio
IPC分类号： A61K31/496 , A61K45/06 , A61N5/10 , A61K31/506 , C07D471/04
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6.发明授权PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS 有权吡咯并[2,3-D]嘧啶衍生物，其制备方法及其作为激酶抑制剂的用途
公开(公告)号：EP2997030B1
公开(公告)日：2017-08-09
申请号：EP14721891.1
申请日：2014-05-07
发明人： ANGIOLINI, Mauro , BUFFA, Laura , MENICHINCHERI, Maria , MOTTO, Ilaria , POLUCCI, Paolo , TRAQUANDI, Gabriella , ZUCCOTTO, Fabio
IPC分类号： C07D487/04
CPC分类号： A61K31/519 , A61K31/496 , A61K45/06 , C07D487/04
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7.发明授权TRICYCLIC PYRROLO DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS 有权三环PYRROLODERIVATE，工艺及其使用AS激酶抑制剂和及其
公开(公告)号：EP2668190B1
公开(公告)日：2016-08-17
申请号：EP12702207.7
申请日：2012-01-19
发明人： CALDARELLI, Marina , ANGIOLINI, Mauro , BERIA, Italo , BRASCA, Maria Gabriella , CASUSCELLI, Francesco , D'ALESSIO, Roberto , LOMBARDI BORGIA, Andrea
IPC分类号： C07D487/04 , A61K31/519 , A61P19/00 , A61P37/00 , A61P35/00 , A61P17/00
CPC分类号： C07D487/04 , A61K31/519 , A61K31/55 , A61K45/06 , C07C67/00 , C07D207/34 , C07D209/42 , C07D401/04 , C12N9/99
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8.发明授权SUBSTITUTED PYRIMIDINYLPYRROLOPYRIDINONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS 有权取代PYRIMIDINYLPYRROLOPYRIDINONDERIVATE，工艺及其使用AS激酶抑制剂和及其
公开(公告)号：EP2443117B1
公开(公告)日：2016-03-23
申请号：EP10725144.9
申请日：2010-06-11
发明人： MARCHIONNI, Chiara , ZUCCOTTO, Fabio , BADARI, Alessandra , ANGIOLINI, Mauro , CARENZI, Davide , CALDARELLI, Marina , PULICI, Maurizio
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04 , A61K31/506 , A61K45/06 , A61N5/00
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9.发明公开SUBSTITUTED PYRIMIDINYL AND PYRIDINYL-PYRROLOPYRIDINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS 有权取代嘧啶和吡啶，PYRROLOPYRIDINONE，工艺及其使用AS激酶抑制剂和及其
公开(公告)号：EP2917214A1
公开(公告)日：2015-09-16
申请号：EP13783956.9
申请日：2013-10-31
发明人： MENICHINCHERI, Maria , ANGIOLINI, Mauro , BERTRAND, Jay Aaron , CARUSO, Michele , POLUCCI, Paolo , QUARTIERI, Francesca , SALOM, Barbara , SALSA, Matteo , ZUCCOTTO, Fabio
IPC分类号： C07D471/04 , A61K31/506 , A61P35/00
CPC分类号： C07D471/04 , A61K31/496 , A61K31/506 , A61K45/06 , A61N5/10
摘要： The present invention relates to substituted pyrimidinyl- and pyridinylpyrrolopyridinone compounds which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular RET family kinases. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions containing these compounds.
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10.发明公开TRICYCLIC PYRROLO DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS 有权三环PYRROLODERIVATE，工艺及其使用AS激酶抑制剂和及其
公开(公告)号：EP2668190A1
公开(公告)日：2013-12-04
申请号：EP12702207.7
申请日：2012-01-19
发明人： CALDARELLI, Marina , ANGIOLINI, Mauro , BERIA, Italo , BRASCA, Maria Gabriella , CASUSCELLI, Francesco , D'ALESSIO, Roberto , LOMBARDI BORGIA, Andrea
IPC分类号： C07D487/04 , A61K31/519 , A61P19/00 , A61P37/00 , A61P35/00 , A61P17/00
CPC分类号： C07D487/04 , A61K31/519 , A61K31/55 , A61K45/06 , C07C67/00 , C07D207/34 , C07D209/42 , C07D401/04 , C12N9/99
摘要： The present invention relates to tricyclic pyrrolo derivatives of Formula (I), which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such these compounds or the pharmaceutical compositions containing them.
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