公开(公告)号：EP1178963A1

公开(公告)日：2002-02-13

申请号：EP00926720.4

申请日：2000-05-12

申请人： NEUROSEARCH A/S

发明人： JENSEN, Bo, Skaaning ,  TEUBER, Lene ,  STR B K, Dorte ,  CHRISTOPHERSEN, Palle ,  OLESEN, S ren, Peter

IPC分类号： C07D213/04 ,  C07D207/32 ,  C07D233/56 ,  C07C205/06 ,  C07C233/07 ,  C07C25/02 ,  A61K31/435 ,  A61K31/40 ,  A61K31/4164 ,  A61K31/167 ,  A61K31/05

CPC分类号： C07C25/02 ,  A61K31/05 ,  A61K31/167 ,  A61K31/40 ,  A61K31/4164 ,  A61K31/435 ,  C07C205/22 ,  C07C233/15 ,  C07D207/32 ,  C07D213/04 ,  C07D233/56

摘要： The present invention relates to ion channel modulating agents. More particularly, the present invention relates to a particular class of chemical compounds represented by general Formula (I) and a pharmaceutically acceptable salt or an oxide or a hydrate thereof, that has proven useful as modulators of SKCa, IKCa and BKCa channels. In further aspects, the present invention relates to the use of these SK/IK/BK channel modulating agents for the manufacture of medicaments, and pharmaceutical compositions comprising the SK/IK/BK channel modulating agents. The SK/IK/BK channel modulating agents of the invention are useful for the treatment or alleviation of diseases and conditions associated with the SK/IK/BK channels.

公开(公告)号：EP1187610A2

公开(公告)日：2002-03-20

申请号：EP00926722.0

申请日：2000-05-12

申请人： NEUROSEARCH A/S

发明人： JENSEN, Bo, Skaaning ,  TEUBER, Lene ,  STR B K, Dorte ,  CHRISTOPHERSEN, Palle ,  OLESEN, S ren, Peter

IPC分类号： A61K31/403 ,  A61K31/404 ,  A61K31/55

CPC分类号： A61K45/06 ,  A61K31/122 ,  A61K31/15 ,  A61K31/403 ,  A61K31/404 ,  A61K31/4045 ,  A61K31/55 ,  Y02A50/409

摘要： The present invention relates to the use of a particular class of chemical compounds as modulators of SKCa, IKCa and BKCa channels, and to pharmaceutical compositions comprising the SK/IK/BK channel modulating agents.