公开(公告)号：EP1501928A1

公开(公告)日：2005-02-02

申请号：EP03731127.1

申请日：2003-05-09

申请人： NEW YORK UNIVERSITY

发明人： ORLOW, Seth, J. ,  MANGA, Prasheila ,  STALEVA, Liliana

IPC分类号： C12N15/09 ,  C12Q1/02 ,  C12Q1/18

CPC分类号： G01N33/5011 ,  G01N33/5008 ,  G01N33/5014 ,  G01N33/5044 ,  G01N33/5097 ,  G01N33/6872 ,  G01N2510/00

摘要： The invention provides methods for the identification of agents that modify or mimic P protein function. Cells expressing a P protein are generally more sensitive to toxins, and changes in cell viability and/or cell death after exposure of P protein-expressing cells to an agent and a toxin is an indication that such an agent is a modifier of P protein expression. The invention also provides methods for the treatment of melanoma and other cancers.

摘要翻译： 本发明提供了用于鉴定修饰或模拟P蛋白功能的试剂的方法。 表达P蛋白的细胞通常对毒素更敏感，并且表达P蛋白的细胞暴露于药剂和毒素后细胞活力和/或细胞死亡的变化表明这种药剂是P蛋白表达的修饰剂 。 本发明还提供了治疗黑素瘤和其他癌症的方法。

公开(公告)号：EP1383474A2

公开(公告)日：2004-01-28

申请号：EP02776548.6

申请日：2002-04-08

申请人： NEW YORK UNIVERSITY

发明人： ORLOW, Seth, J. ,  HALL, Andrea ,  MANGA, Prasheila

IPC分类号： A61K7/135 ,  A61K31/74 ,  A61K9/00 ,  A61K6/00 ,  A61K9/14 ,  A61K38/00 ,  C07K1/00 ,  C07K2/00 ,  C07K4/00 ,  C07K5/00 ,  C07K7/00 ,  C07K14/00 ,  C07K16/00 ,  C07K17/00 ,  C12Q1/00 ,  G01N33/53 ,  G01N33/567

CPC分类号： A61K8/4906 ,  A61K8/72 ,  A61K31/56 ,  A61Q19/02 ,  C12Q1/26 ,  G01N33/5008 ,  G01N33/502 ,  G01N33/5035 ,  G01N33/5044 ,  G01N33/5076 ,  G01N33/5088 ,  G01N33/6881 ,  G01N2333/90219 ,  G01N2500/00 ,  G01N2500/10 ,  G01N2800/207

摘要： The invention provides methods of screening for compounds that affect melanogenesis and the function of P protein in organisms, cells, or cell-free systems. The invention further relates to pharmacologic and cosmetic uses of methods of inhibiting melanogenesis, methods of activating melanogenesis, and compounds and pharmacologic compositions useful for the inhibition or activation of melanogenesis and, therefore, for lightening or darkening the pigmentation of cells and tissue, i.e., skin.