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公开(公告)号：EP3648793A1
公开(公告)日：2020-05-13
申请号：EP18734576.4
申请日：2018-07-04
申请人： NH THERAGUIX , Université Claude Bernard Lyon 1 , Centre National de la Recherche Scientifique - CNRS , (INSERM) Institut National de la Santé et de la Recherche Médicale , Institut Gustave Roussy
发明人： LUX, François , TILLEMENT, Olivier , PERFETTINI, Jean-Luc , DEUTSCH, Eric , LAW, Frédéric , ALLOUCH, Awatef
IPC分类号： A61K41/00
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公开(公告)号：EP3424533A1
公开(公告)日：2019-01-09
申请号：EP17305869.4
申请日：2017-07-05
申请人： NH THERAGUIX , Université Claude Bernard Lyon 1 , Centre National de la Recherche Scientifique (CNRS) , INSERM (Institut National de la Santé et de la Recherche Médicale) , Institut Gustave Roussy
发明人： LUX, François , TILLEMENT, Olivier , PERFETTINI, Jean-Luc , DEUTSCH, Eric , LAW, Frédéric , ALLOUCH, Awatef
IPC分类号： A61K41/00
摘要： The invention relates to methods for treating tumors. In particular, the invention provides novel use of nanoparticles in combination with ionizing radiations for treating tumors, wherein the combined effect of nanoparticles induces senescence and/or cannibalism of the tumor cells.
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公开(公告)号：EP3795178A1
公开(公告)日：2021-03-24
申请号：EP19306138.9
申请日：2019-09-19
申请人： NH THERAGUIX , Institut Gustave Roussy , UNIVERSITE CLAUDE BERNARD - LYON 1 , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE -CNRS- , INSERM (Institut National de la Santé et de la Recherche Médicale) , Universite Paris-Sud
IPC分类号： A61K41/00 , A61K47/69 , A61K49/18 , A61P35/00 , A61P1/16 , A61P9/10 , A61P11/00 , A61P37/08 , A61K39/00 , A61N5/10
摘要： The present disclosure relates to the field of nanomedicine, in particular for treating cancers. The present disclosure more specifically provides new methods of treating undesirable M2-polarized macrophages and/or inducing M1 macrophage polarization in a subject in need thereof, comprising administering to said subject a therapeutically effective amount of nanoparticles containing metallic elements.
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4.发明公开METHODS AND PHARMACEUTICAL COMPOSITION FOR MODULATION POLARIZATION AND ACTIVATION OF MACROPHAGES 审中-公开调节极化和活化巨噬细胞的方法和药物组合物
公开(公告)号：EP3297615A1
公开(公告)日：2018-03-28
申请号：EP16725818.5
申请日：2016-05-20
申请人： INSERM - Institut National de la Santé et de la Recherche Médicale , Universite Paris-Sud , Institut Gustave Roussy (IGR) , Institut Pasteur , Assistance Publique-Hôpitaux de Paris , Université Paris Descartes , Université Paris Diderot (Paris 7) , Université Pierre et Marie Curie (Paris 6) , Istituto Nazionale per le Malattie Infettive "Lazzaro Spallanzani" I.R.C.C.S
发明人： PERFETTINI, Jean-Luc , PAOLETTI, Audrey , GOUGEON, Marie-Lise , KROEMER, Guido. , PIACENTINI, Mauro.
CPC分类号： A61K31/7072 , A61K31/00 , A61K31/7034 , A61K31/7076 , A61K31/7084 , A61K38/177 , A61K48/00 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/00 , Y02A50/385 , Y02A50/401 , Y02A50/409 , Y02A50/411 , Y02A50/473 , Y02A50/478
摘要： The present invention relates to methods and pharmaceutical composition for modulation polarization and activation of macrophages. In particular, the present invention relates to methods for modulating macrophage M1/M2 polarization in a subject in need thereof comprising administering to the subject a therapeutically effective amount of P2Y2 receptor agonists or antagonists.
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公开(公告)号：EP4146297A1
公开(公告)日：2023-03-15
申请号：EP21732410.2
申请日：2021-04-30
申请人： Mexbrain , UNIVERSITE CLAUDE BERNARD - LYON 1 , Centre National de la Recherche Scientifique (CNRS) , Institut National de la Santé et de la Recherche Médicale (INSERM) , Institut Gustave Roussy (IGR) , Vetagro-Sup Institut d'Enseignement Superieur et de Recherche
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公开(公告)号：EP4031180A1
公开(公告)日：2022-07-27
申请号：EP20771594.7
申请日：2020-09-18
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公开(公告)号：EP3516076A1
公开(公告)日：2019-07-31
申请号：EP17778218.2
申请日：2017-09-19
IPC分类号： C12Q1/68 , G01N33/574
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公开(公告)号：EP3999080A1
公开(公告)日：2022-05-25
申请号：EP20740038.3
申请日：2020-07-17
IPC分类号： A61K35/15 , C12N5/0786 , A61K39/00
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9.发明公开METHODS AND PHARMACEUTICAL COMPOSITIONS FOR TREATING HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (HIV-1) INFECTIONS 审中-公开治疗人类免疫缺陷病毒1型（HIV-1）感染的方法和药物组合物
公开(公告)号：EP3230455A1
公开(公告)日：2017-10-18
申请号：EP15808183.6
申请日：2015-12-10
申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) , Université Paris-Sud , Institut Gustave Roussy , Université Paris Descartes , Université Pierre et Marie Curie (Paris 6) , Institut Pasteur , Istituto Nazionale per le Malattie Infettive "Lazzaro Spallanzani" I.R.C.C.S , Assistance Publique-Hôpitaux de Paris (APHP)
发明人： KROEMER, Guido , PERFETTINI, Jean-Luc , GOUGEON, Marie-Lise , ALLOUCH, Awatef , PIACENTINI, Mauro
IPC分类号： C12N15/113 , A61K31/7088
CPC分类号： C12N15/113 , A61K31/165 , A61K31/17 , A61K31/395 , A61K31/5517 , A61K31/683 , A61K31/7088 , A61K31/713 , A61K45/06 , C12N15/1132 , C12N2310/14 , C12N2320/31 , C12Q1/18 , A61K2300/00
摘要： The present invention provides methods and pharmaceutical compositions for treating human immunodeficiency virus type 1 (HIV-1) infections. In particular, the present invention relates to a method for treating HIV-1 infection in a subject in need thereof comprising administering the subject with a therapeutically effective amount of an inhibitor of SGT1 activity or expression.
摘要翻译： 本发明提供了用于治疗1型人免疫缺陷病毒（HIV-1）感染的方法和药物组合物。 具体而言，本发明涉及在有此需要的受试者中治疗HIV-1感染的方法，其包括向受试者施用治疗有效量的SGT1活性或表达抑制剂。
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10.发明公开
公开(公告)号：EP4157288A2
公开(公告)日：2023-04-05
申请号：EP21728935.4
申请日：2021-06-01
发明人： PERFETTINI, Jean-Luc , LECUYER, Deborah , TANNOUS, Désirée , ALLOUCH, Awatef , DELELIS, Olivier , SUBRA, Frederic
IPC分类号： A61K31/7084 , A61K31/675 , A61K31/7072 , A61P11/00 , A61P31/14 , A61K45/06
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