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14 条记录 (耗时 0.013 秒)

    Amino-alcohol derivatives and processes for their preparation
    1.
    发明公开
    Amino-alcohol derivatives and processes for their preparation 失效
    Aminoalkohol-Derivate und Verfahren zu ihrer Herstellung。

    公开(公告)号：EP0177245A2

    公开(公告)日：1986-04-09

    申请号：EP85306767.6

    申请日：1985-09-24

    申请人： NIPPON CHEMIPHAR CO., LTD.

    发明人： Masaki, Mitsuo ,  Shinozaki, Haruhiko ,  Satoh, Masuru ,  Moritoh, Naoya ,  Hashimoto, Koichi ,  Kamishiro, Toshiro

    IPC分类号： C07D295/12 ,  C07C215/56 ,  C07C217/44

    CPC分类号： C07D295/13

    摘要： Amino-alcohol derivatives of the formula,
    where R, is a straight or branched alkyl group having 3 to 8 carbon atoms, R 2 and R 3 are each a lower alkyl group, or R 2 and R 3 form a 5- to 7-membered ring together with the adjacent nitrogen atom which may have an oxygen atom attached thereto, R. is a hydrogen atom or a lower alkyl group, R 5 is a hydrogen atom or a lower alkyl group, X is a hydrogen or halogen atom or a lower alkyl or lower alkoxy group, and n is an integer of 2 or 3, and acid addition salts thereof, are effectively useful as medicines and agricultural chemicals. Processes are also disclosed for preparing such compounds.

    摘要翻译： 其中R 1是具有3至8个碳原子的直链或支链烷基，R 2和R 3各自是低级烷基，或者R 2和R 3形成5-至7-元环的下式的氨基醇衍生物 与可能具有氧原子的相邻氮原子一起，R4是氢原子或低级烷基，R5是氢原子或低级烷基，X是氢或卤素原子或低级烷基或低级烷基 烷氧基，n为2或3的整数，其酸加成盐可有效用作药物和农药。 还公开了制备这些化合物的方法。

    Novel glycerol derivative and anti-hypertensive agent
    2.
    发明公开
    Novel glycerol derivative and anti-hypertensive agent 失效
    甘油 - 衍生和抗高血压药物Mittel。

    公开(公告)号：EP0284395A2

    公开(公告)日：1988-09-28

    申请号：EP88302621.3

    申请日：1988-03-24

    申请人： NIPPON CHEMIPHAR CO., LTD.

    发明人： Masaki, Mitsuo ,  Takeda, Hiromitsu ,  Kamishiro, Toshiro ,  Yamamoto, Masao

    IPC分类号： C07F9/10 ,  C07F9/58 ,  C07F9/60 ,  C07F9/62 ,  C07F9/547 ,  A61K31/685

    CPC分类号： C07F9/60 ,  C07F9/10 ,  C07F9/5722 ,  C07F9/5725 ,  C07F9/5765 ,  C07F9/582 ,  C07F9/592 ,  C07F9/595 ,  C07F9/62 ,  C07F9/6539

    摘要： A novel glycerol derivative which is effective to reduce blood pressure has the formula:
    wherein R¹ is an alkyl group having 10-22 carbon atoms, R² is lower acyl, benzoyl, aryl, mono-, di- or triaryl­alkyl, alkyl, cycloalkyl, or cycloalkylalkyl; Q is sub­stituted or unsubstituted alkylene containing 1-4 carbon atoms, ℓ is 0 or 1; Y is a nitrogen-containing heterocy­clic group or a nitrogen-containing bridged heterocyclic group (-(Q) ℓ - is attached to a carbon atom contained in a hetero-ring of the heterocyclic group) in which Y is the bridged heterocyclic group where ℓ is 0; and each of R⁵, R⁶ and R⁷ is hydrogen, lower alkyl, aryl or aralkyl.

    摘要翻译： 有效降低血压的新型甘油衍生物具有下式：其中R 1是具有10-22个碳原子的烷基，R 2是低级酰基，苯甲酰基，芳基，单，二 - 或三芳基烷基，烷基，环烷基或环烷基烷基; Q是取代或未取代的含有1-4个碳原子的亚烷基，l是0或1; Y是含氮杂环基或含氮桥连杂环基（ - （Q）1 - 与杂环基杂环中杂环上含有的碳原子连接），其中Y是桥连杂环基，其中l 是0; R 5，R 6和R 7各自为氢，低级烷基，芳基或芳烷基。

    Novel quinaldinamide derivatives and their preparations
    6.
    发明公开
    Novel quinaldinamide derivatives and their preparations 失效
    2-Chinolincarbonsäureamid-Derivate und ihre Herstellung。

    公开(公告)号：EP0256181A1

    公开(公告)日：1988-02-24

    申请号：EP86306294.9

    申请日：1986-08-14

    申请人： NIPPON CHEMIPHAR CO., LTD.

    发明人： Masaki, Mitsuo ,  Shinozaki, Haruhiko ,  Satoh, Masaru ,  Moritoh, Naoya ,  Hashimoto, Koichi ,  Kamishiro, Toshiro

    IPC分类号： C07D215/48 ,  A61K31/47

    CPC分类号： C07D215/48 ,  Y10S514/906

    摘要： A novel quinaldinamide derivative having the formula:
    wherein each of R 1 and R 2 independently represents a lower alkyl group or R 1 and R 2 are combined together with the adjacent nitrogen atom to form a 5 - 7 membered ring; and X represents the hydrogen atom, a lower alkyl group or a lower alkoxy group, and its acid-addition salt, which show prominent central muscle relaxant effect, namely, rigidity relieving effect on anemic decerebrated rigidity.

    摘要翻译： 具有下式的新颖的喹哪啶衍生物：其中R 1和R 2各自独立地代表低级烷基或R 1和R 2与相邻的氮原子一起形成 5-7元环; X表示氢原子，低级烷基或低级烷氧基，及其酸加成盐，具有显着的中枢肌松弛作用，即缓解刚性减轻刚性的刚性。

    Alkylenediamine derivatives
    7.
    发明公开
    Alkylenediamine derivatives 失效
    Alkylendiamin衍。

    公开(公告)号：EP0235942A1

    公开(公告)日：1987-09-09

    申请号：EP87300850.2

    申请日：1987-01-30

    申请人： NIPPON CHEMIPHAR CO., LTD.

    发明人： Masaki, Mitsuo ,  Shinozaki, Haruhiko ,  Satoh, Masaru ,  Mortioh, Naoya ,  Hashimoto,Koichi ,  Kamishiro, Toshiro

    IPC分类号： C07D295/12 ,  A61K31/395

    CPC分类号： C07D295/13

    摘要： Novel alkylenediamine derivative having the formula (I):
    wherein A is a group having the formula (II):
    (wherein R 1 is an aliphatic hydrocarbon group, an alicyclic group, an aryl group, or an aralkyl group; R 2 is an aliphatic hydrocarbon group, en alkoxy group, an aliphatic hydrocarbon group containing an ester or ether bonding, or an aryloxy group; and each of m and n is an integer of 0 to 2, provided that m + n does not exceed 3) and B is hoydrogen, or
    A is a group having the formula (III):
    (wherein R 3 has the same meaning as that of R 1 and k is an integer of 0 to 3) and B is a group repesenting by the formula (IV):
    wherein R 4 has almost the same meaning as that of R 2 , p is an integer of 2 to 6, and q is an integer of 4 to 7.
    These compounds are useful as glutamate blockers.

    摘要翻译： 具有式（I）的新型亚烷基二胺衍生物：其中A是具有式（II）的基团：R 1（CH 2）m -CH（R 2） - （CH 2）n - （II） （其中R 1是脂族烃基，脂环基，芳基或芳烷基; R 2是脂族烃基，en烷氧基，含有酯或醚键的脂族烃基， 或芳氧基; m和n分别为0〜2的整数，条件是m + n不超过3），B为氢氧根，或A为具有式（III）的基团：R 3 - （CH 2）k - （III）（其中R 3具有与R 1相同的含义，k为0至3的整数），B为式（Ⅳ）表示的基团：R 其中R 4与R 2具有几乎相同的含义，p为2〜6的整数，q为4〜7的整数。这些化合物可用作谷氨酸 阻滞剂。

    Use of imidazole derivative for antihypertensive agent
    8.
    发明公开
    Use of imidazole derivative for antihypertensive agent 失效
    Verwendung von Imidazol-Derivaten als blutdrucksenkendes Mittel。

    公开(公告)号：EP0633026A1

    公开(公告)日：1995-01-11

    申请号：EP94110404.4

    申请日：1994-07-04

    申请人： NIPPON CHEMIPHAR CO., LTD.

    发明人： Masaki, Mitsuo ,  Hara, Fumiyo ,  Kamishiro, Toshiro

    IPC分类号： A61K31/415 ,  A61K31/47

    CPC分类号： A61K31/415 ,  A61K31/47

    摘要： The disclosed antihypertensive agent comprises an imidazole derivative of the formula:

    wherein each of R¹ and R² is hydrogen, substituted or unsubstituted alkyl, alkoxyalkyl, cycloalkyl, aryl, aralkyl, or R¹ and R² are combined to form hetero ring; each of R 3, R 4, R⁵ and R⁶ is hydrogen, halogen, substituted or unsubstituted alkoxy, substituted or unsubstituted alkyl, aryl, aryloxy, alkoxycarbonyl, nitro, amino, acyl, or R³ is combined with R² to form heteroring; R⁷ is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted arylcarbonyl, or S-containing heteroring; each of R⁸and R⁹ is hydrogen, halogen, substituted or unsubstituted alkoxy, unsubstituted or substituted alkyl, alkoxycarbonyl, aralkyl, nitro, amino, acyl, substituted or unsubstituted aryl, or R⁸ and R⁹ are combined to from alkylene; and n is 0 or 1.

    摘要翻译： 所公开的抗高血压剂包括下式的咪唑衍生物：其中R 1和R 2各自为氢，取代或未取代的烷基，烷氧基烷基，环烷基，芳基，芳烷基或R 1和R 2 <2>结合形成杂环; R 3，R 4，R 5和R 6各自为氢，卤素，取代或未取代的烷氧基，取代或未取代的烷基，芳基，芳氧基，烷氧基羰基，硝基，氨基，酰基或R <3>与R 2结合形成杂环; R 7是氢，取代或未取代的烷基，取代或未取代的芳基，取代或未取代的芳基羰基或含S的杂环; R 8和R 9各自为氢，卤素，取代或未取代的烷氧基，未取代或取代的烷基，烷氧基羰基，芳烷基，硝基，氨基，酰基，取代或未取代的芳基，或R 8和R 9 >从亚烷基组合; n为0或1。