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    Novel glycerol derivative and anti-hypertensive agent
    2.
    发明公开
    Novel glycerol derivative and anti-hypertensive agent 失效
    甘油 - 衍生和抗高血压药物Mittel。

    公开(公告)号：EP0284395A2

    公开(公告)日：1988-09-28

    申请号：EP88302621.3

    申请日：1988-03-24

    申请人： NIPPON CHEMIPHAR CO., LTD.

    发明人： Masaki, Mitsuo ,  Takeda, Hiromitsu ,  Kamishiro, Toshiro ,  Yamamoto, Masao

    IPC分类号： C07F9/10 ,  C07F9/58 ,  C07F9/60 ,  C07F9/62 ,  C07F9/547 ,  A61K31/685

    CPC分类号： C07F9/60 ,  C07F9/10 ,  C07F9/5722 ,  C07F9/5725 ,  C07F9/5765 ,  C07F9/582 ,  C07F9/592 ,  C07F9/595 ,  C07F9/62 ,  C07F9/6539

    摘要： A novel glycerol derivative which is effective to reduce blood pressure has the formula:
    wherein R¹ is an alkyl group having 10-22 carbon atoms, R² is lower acyl, benzoyl, aryl, mono-, di- or triaryl­alkyl, alkyl, cycloalkyl, or cycloalkylalkyl; Q is sub­stituted or unsubstituted alkylene containing 1-4 carbon atoms, ℓ is 0 or 1; Y is a nitrogen-containing heterocy­clic group or a nitrogen-containing bridged heterocyclic group (-(Q) ℓ - is attached to a carbon atom contained in a hetero-ring of the heterocyclic group) in which Y is the bridged heterocyclic group where ℓ is 0; and each of R⁵, R⁶ and R⁷ is hydrogen, lower alkyl, aryl or aralkyl.

    摘要翻译： 有效降低血压的新型甘油衍生物具有下式：其中R 1是具有10-22个碳原子的烷基，R 2是低级酰基，苯甲酰基，芳基，单，二 - 或三芳基烷基，烷基，环烷基或环烷基烷基; Q是取代或未取代的含有1-4个碳原子的亚烷基，l是0或1; Y是含氮杂环基或含氮桥连杂环基（ - （Q）1 - 与杂环基杂环中杂环上含有的碳原子连接），其中Y是桥连杂环基，其中l 是0; R 5，R 6和R 7各自为氢，低级烷基，芳基或芳烷基。

    Optically active piperazine derivative
    3.
    发明公开
    Optically active piperazine derivative 失效
    Optisch aktive Piperazin-Derivate。

    公开(公告)号：EP0354068A2

    公开(公告)日：1990-02-07

    申请号：EP89308014.3

    申请日：1989-08-07

    申请人： NIPPON CHEMIPHAR CO., LTD.

    发明人： Nohira, Hiroyuki ,  Masaki, Mitsuo ,  Yamamoto, Masao

    IPC分类号： C07D295/096 ,  A61K31/495

    CPC分类号： C07D295/092

    摘要： A novel (-)-optically active piperazine derivative of the formula:
    (wherein the mark of * indicates an optically active car­bon) shows an increased cerebral circulation-improving effect as well as an enhanced safety.

    摘要翻译： 具有下式的新型（ - ） - 光学活性哌嗪衍生物：（其中*的标记表示光学活性碳）显示增加的脑循环改善效果以及增强的安全性。

    Novel glycerol derivative and anti-hypertensive agent
    9.
    发明公开
    Novel glycerol derivative and anti-hypertensive agent 失效
    Glycerolderivat和抗高血压药Mittel。

    公开(公告)号：EP0257762A2

    公开(公告)日：1988-03-02

    申请号：EP87306211.1

    申请日：1987-07-14

    申请人： NIPPON CHEMIPHAR CO., LTD.

    发明人： Masaki, Mitsuo ,  Takeda, Hiromitsu ,  Kamishiro, Toshiro ,  Yamamoto, Masao

    IPC分类号： C07F9/547 ,  A61K31/675

    CPC分类号： C07F9/5532 ,  C07F9/10 ,  C07F9/5725 ,  C07F9/595

    摘要： A glycerol derivative which is effective to reduce blood pressure and has the formula:
    wherein R¹ is an alkyl group having 10-22 carbon atoms, R² is a lower acyl group or benzoyl, each of R³ and R⁴ independetly is hydrogen or a straight or branched chain alkyl group having 1-6 carbon atoms;each of R⁵, R⁶ and R⁷ independently is hydrogen, a straight or branched chain alkyl group having 1-6 carbon atoms, an aryl group or an aralkyl group; and each of m and n independently is 0 or a positive integer under the condition of m+n = 2 - 8.

    摘要翻译： 一种有效降低血压的甘油衍生物，具有下式：其中R 1是具有10-22个碳原子的烷基，R 2是低级酰基或苯甲酰基， 3>和R 4独立地是氢或具有1-6个碳原子的直链或支链烷基; R 5，R 6和R 7各自独立地是氢，直链或支链 具有1-6个碳原子的烷基，芳基或芳烷基; 在m + n = 2-8的条件下，m和n各自独立地为0或正整数。